Six-Year Incidence and Baseline Risk Factors for Pseudoexfoliation in a South Indian Population

Vijaya, Lingam; Asokan, Rashima; Panday, Manish; Choudhari, Nikhil S.; Ramesh, Shruthy Vaishali; Velumuri, Lokapavani; George, Ronnie

doi:10.1016/j.ophtha.2015.02.007

Cited by 20 publications

(27 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study the prevalence of Pseudoexfoliation syndrome was 4.45% (95% confidence interval (CI), 3.98-4.97), this prevalence was comparable to results reported by Vijaya et al ( 2015) (Vijaya et al, 2015) who examined 7774 subjects in south India, then followed them for six years, and found the prevalence of Pseudoexfoliation syndrome among that population to be 3.73% (95% CI, 3.73-4.2), also in another study done by Jasna Pavičić-Astaloš, et al ( 2016) in north-west Croatia (Pavičić-Astaloš et al, 2016), which included 5349 subjects and found the prevalence of Pseudoexfoliation syndrome among them to be 3.6%, it's well known that the prevalence differs with age, sex, and more importantly with the geographic location of a population and ethnicity, also genetic predisposition like LOLX1 variants (Anastasopoulos, Founti & Topouzis, 2015).…”

Section: Discussionsupporting

confidence: 90%

“…In the current study, sex distribution of PEX was very similar with males forming 51.7% compared to 48.3% females, similar results were reported by Vijaya et al (2015), with 44.7% male and 55.4% female, but Raşit Kılıç (2014) in Turkey (Kılıç et al, 2014) reported more male predominance with 66.04% male compared to 33.96% females, in their study which identified PEX in 212 (10.1%) of the total 2103 participant, but another earlier Turkish study done by Cumurcu et al (2010) (Cumurcu, Kilic, & Yologlu, 2010) reported no sex difference in PEX prevalence.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Clinical Survey of Pseudoexfoliation Syndrome

Mansoor¹,

Fawzi²

2019

GJHS

View full text Add to dashboard Cite

OBJECTIVE: Assess the prevalence &lrm;of PEX and identify the associated glaucoma and &lrm;cataract.&lrm; STUDY DESIGN & METHODOLOGY: A sample of 6,650 patients (age ≥40 years) that attended the single &lrm;ophthalmic private clinic for &lrm;different complaints, for five years (January 2013 until January 2018), those diagnosed with &lrm;PEX &rlm;enrolled in this study, with a total number of 296 &lrm;patients.&lrm; RESULTS: &lrm;14 (4.7%) patients with age from 40-49 years, 54(18.2%) from 50-&lrm;&lrm;59 years, 102 (34.5%) from &lrm;&lrm;60-69 years, and 126(42.6%) equal or older &lrm;than 70 years. Close sex frequencies were observed, &lrm;with 153(51.7%) &lrm;males, and 143(48.3%) females. In the current study, the prevalence of &lrm;PEX &lrm;was 4.45% (95% confidence interval (CI), &lrm;&lrm;3.98-4.97). There was a statistically insignificant &lrm;relationship between PEG &lrm;or advanced glaucoma with age or sex, but cataract was &lrm;significantly &lrm;associated with older age and male sex.&lrm; CONCLUSION: The prevalence of Pseudoexfoliation syndrome was 4.45%, with a sharp increase after the &lrm;age &lrm;of 50 years. Although the &lrm;prevalence of PEG and advanced glaucoma increased with age, it &lrm;was &lrm;neither statistically associated with it, nor with sex&rlm;.&rlm;&lrm; Cataract prevalence &lrm;was associated &lrm;with increased age and male sex.&lrm;

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Clinical Survey of Pseudoexfoliation Syndrome

Mansoor¹,

Fawzi²

2019

GJHS

View full text Add to dashboard Cite

show abstract

“…A south Indian based population survey evaluating patients at baseline and at 6 years found an incidence of 2% exfoliation, glaucoma in 1% and 2% OHT incidence. [ 17 , 18 ] We found a prevalence of 11.5% in a tertiary eye care center in East India with a prevalence of 25% of exfoliation glaucoma and 13% with OHT in this hospital based survey which was higher in combined forms of PXF than even classical form of the disease. This study was an EMR based audit of a single center with its inherent biases due to possible faulty entry affecting data retrieval which cannot be directly extrapolated to population prevalence.…”

Section: Discussionmentioning

confidence: 64%

Clinical spectrum of pseudoexfoliation syndrome—An electronic records audit

et al. 2017

View full text Add to dashboard Cite

PurposeTo evaluate different clinical variants of pseudoexfoliation syndrome and their risk of developing ocular hypertension (OHT) or glaucoma (PXG)DesignCross sectional hospital based study.SettingAll patients seen at glaucoma services of a tertiary eye care center in east India.MethodsElectronic medical records search of hospital database including consecutive new and old cases seen during April 2013 to March 2015 was done to retrieve case sensitive words including pseudoexfoliation, PXF, PEX, PXG and pseudoexfoliative glaucoma over any part of the clinical electronic sheet of the patient. All demographic and clinical details including laterality, the pattern of deposits, need for medicines and disc damage at presentation was compared in eyes with radial pigmentary, classical or combined forms of PXF phenotypes.ResultsOf 110313 PXF patients seen during the period of 2013–2015, a total of 2297 eyes of 1150 PXF patients were identified including 525 unilateral PXF (meaning a total of 1775 PXF eyes with 625 patients having bilateral disease, n = 1250 eyes, other clinically normal eye, n = 522) at presentation. Of 525 unilateral PXF eyes, 105 had OHT and 131 had glaucoma while bilateral cases had more >50% (675 eyes of 1250 eyes) with glaucoma. Glaucoma with significant changes in IOP with or without disc damage was seen in 32% of pigmentary and 39% of classical PXF forms with eyes with combined forms of PXF having around 50% with glaucoma at presentation compared to other forms, p<0.001.ConclusionDifferent phenotypic variants of PXF in this Indian cohort was associated with 30–50% risk of OHT or glaucoma respectively. Adequate care is required while examining the pattern of PXF in each case to prognosticate each patient/eye.

show abstract

“…The prevalence of PEX in at least one eye in Kumejima residents aged 40 years or older was 1.5% when eyes after cataract surgery were excluded, and 2.8% when eyes after cataract surgery were included. An apparently higher value in the latter group should be mainly attributed to possibly higher association of PEX and cataract (Krause & Tarkkanen 1978;Rudkin et al 2008;Landers et al 2012;Vijaya et al 2015). It should be also associated that eyes with PEX and cataract had undergone early cataract surgery to minimize possible intraoperative complications (Naumann et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Pseudoexfoliation syndrome and relating factors in a rural Japanese population: the Kumejima Study

Arakaki

Sawaguchi

Iwase

et al. 2020

Acta Ophthalmologica

View full text Add to dashboard Cite

To report the prevalence of pseudoexfoliation (PEX) syndrome and glaucoma associated with PEX (PEX-G) and their relating factors of them in a southwestern island of Japan. Methods: A population-based survey of all residents aged ≥ 40 years was conducted in Kumejima, Okinawa, Japan, and 3762 subjects (participation rate, 81.2%) underwent detailed ophthalmic examinations. Presence of PEX material on the lens capsule, iris surface and/or pupillary margin was determined by slitlamp biomicroscopy. Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology. Results: In subjects aged ≥ 40 years, prevalence rates of PEX syndrome, PEX without glaucoma and PEX-G in at least one eye were 1.5% (95% confidence interval [CI]: 1.0-1.9%), 1.3% (95% CI: 0.9-1.7%) and 0.1% (95% CI: 0.0-0.2%), respectively, excluding eyes after cataract surgery; and 2.8% (95% CI: 2.3-3.3%), 2.2% (95% CI: 1.8-2.6 %) and 0.4% (95% CI: 0.2-0.6%), respectively, including eyes after cataract surgery. Cataract surgery had been performed in 61% of subjects with PEX in at least one eye; presence of PEX showed no significant effects on the intraocular pressure (IOP). A multivariate analysis showed that PEX was associated with older age (p < 0.0001, odds ratio: 1.10 [95% CI: 1.07-1.13]) and working outdoors (p = 0.0395, odds ratio: 2.18 [95% CI: 0.99-4.82]). Conclusions: The prevalence rates of PEX syndrome and PEX-G in a southwestern island of Japan were reported. PEX showed no significant effect on IOP, and age and working outdoors were significantly related with PEX.

show abstract

Six-Year Incidence and Baseline Risk Factors for Pseudoexfoliation in a South Indian Population

Cited by 20 publications

References 41 publications

Clinical Survey of Pseudoexfoliation Syndrome

Clinical Survey of Pseudoexfoliation Syndrome

Clinical spectrum of pseudoexfoliation syndrome—An electronic records audit

Pseudoexfoliation syndrome and relating factors in a rural Japanese population: the Kumejima Study

Contact Info

Product

Resources

About