Six‐year‐old girl with primary cutaneous aggressive epidermotropic CD8<sup>+</sup> T‐cell lymphoma

Kikuchi, Yukiko; Kashii, Yoshifumi; Gunji, Yuji; Morimoto, Akira; Masuzawa, Aki; Takatsuka, Yuka; Fujita, Etsuko; Komine, Mayumi; Ohtsuki, Mamitaro; Matsubara, Daisuke; Kobayashi, Chie; Sakurai, Ayako; Yanase, Kentaro; Kato, Keisuke; Koike, Kenichi; Tsuchida, Masahiro; Momoi, Mariko Y.

doi:10.1111/j.1442-200x.2011.03369.x

Cited by 19 publications

(13 citation statements)

References 11 publications

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“…Apart from this case, Kikuchi et al . documented primary cutaneous aggressive epidermotropic CD8 + T‐cell lymphoma in a 6‐year‐old girl, presenting with unusual features including hypersensitivity to mosquito bites, peripheral lymph node involvement by CD8+ cells and large (up to 10 cm) cutaneous necrotic lesions …”

Section: Resultsmentioning

confidence: 99%

“…104 Apart from this case, Kikuchi et al documented primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma in a 6-year-old girl, presenting with unusual features including hypersensitivity to mosquito bites, peripheral lymph node involvement by CD8+ cells and large (up to 10 cm) cutaneous necrotic lesions. 105 Primary cutaneous c/d+ T-cell lymphoma (CGD-TCL) is a rare malignancy characterized by a clonal proliferation of mature activated c/d T cells thought to derive from local organ-specific c/d T-cell populations. 106,107 The disease is rare with approximately 100 cases reported to date.…”

Section: Extranodal Nk/t-cell Lymphoma Nasal-type Hydroa Vacciniformentioning

confidence: 99%

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Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Kempf

Kazakov

Белоусова

et al. 2015

Acad Dermatol Venereol

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Primary cutaneous lymphomas (CL) in children is rare. Only a few studies focused specifically on paediatric CL and therefore little is known whether primary CL in children are similar to or different from their adult counterparts with respect to the clinicopathological presentation, behaviour and prognosis. An extensive literature search using PubMed/MEDLINE from January 1995 through July 2014 was undertaken for articles reporting cases of paediatric CL. In addition, we identified 31 children with CL in our institutions. Mycosis fungoides and lymphomatoid papulosis are the two most prevalent lymphoma forms in children. A few entities of cutaneous lymphomas such as cutaneous diffuse large B-cell lymphoma leg type, and Sézary syndrome have not been reported so far in children. Other lymphoma entities such as hydroa vacciniforme-like lymphoma are mostly seen in certain geographic areas (Asia, Central and South America). In the paediatric population, low-malignant indolent forms such as primary cutaneous marginal zone lymphoma and primary cutaneous follicle centre lymphoma are very rare, whereas the more aggressive forms of B-cell lymphomas, precursor lymphoblastic lymphomas, and blastic plasmacytoid dendritic cell neoplasm are the most common forms in children, mostly involving the skin secondarily. Most paediatric lymphomas have similar clinicopathological features and course as their adults counterparts, particularly in the group of cutaneous T-cell lymphomas. The spectrum of cutaneous B-cell lymphomas in children significantly differs from the one in adults. Diagnostic work-up and treatment of paediatric patients with lymphomas are best achieved in close collaboration with paediatric haematopathologists and oncologists.

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Section: Resultsmentioning

confidence: 99%

Section: Extranodal Nk/t-cell Lymphoma Nasal-type Hydroa Vacciniformentioning

confidence: 99%

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Kempf

Kazakov

Белоусова

et al. 2015

Acad Dermatol Venereol

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“…Recently, Cerroni et al reported subcutaneous panniculitis‐like T‐cell lymphoma with features similar to those of lupus panniculitis; however, the involvement of the epidermis was not evident in these cases . Our case should also not be confused with primary cutaneous aggressive epidermotropic CD8 + T‐cell lymphoma, which has been reported in children . However, primary cutaneous aggressive epidermotropic CD8 + T‐cell lymphoma is usually aggressive in its clinical behavior, whereas our patient was living for 3 years with the disease and responded well to prednisone.…”

Section: Discussionmentioning

confidence: 45%

“…10,11 Our case should also not be confused with primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma, which has been reported in children. 12 However, primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma is usually aggressive in its clinical behavior, whereas our patient was living for 3 years with the disease and responded well to prednisone. Histopathologically, primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma usually occur in the epidermis and dermis, 5 -7 whereas our case prominently involved the subcutaneous tissue.…”

Section: Discussionmentioning

confidence: 58%

Primary cutaneous CD8+ cytotoxic T‐cell lymphoma involving the epidermis and subcutis in a young child

2015

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CD8+ cytotoxic T-cell lymphoma involving the skin represents a heterogeneous group of diseases that include subcutaneous panniculitis-like T-cell lymphoma, primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, and 'type D' lymphomatoid papulosis. In this report, we describe a case of CD8+ cytotoxic T-cell lymphoma involving both the epidermis and subcutis. The patient was a 6-year-old girl who presented with a 3-year history of multiple plaques on her trunk and legs. The lesions had relapsed twice but responded well to prednisone. Histopathologic examination showed the proliferation of atypical lymphocytes in the epidermis, dermis and subcutaneous tissue. On immunohistochemical analysis, the atypical lymphocytes were positive for βF1, CD3, CD8, perforin, granzyme B and TIA-1, but negative for T-cell receptor (TCR) γ, CD4, CD30 and CD56. It was difficult to classify this tumor in terms of the known types of cutaneous lymphoma, and this case should be differentiated with subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.

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“…To date, there is no controlled trial showing a survival benefit from any of the therapies. In the future, reduced-intensity conditioning followed by allogeneic stem cell transplantation may be effective as an alternative treatment 14 , even among pediatric patients. With progression of the primary CL, other clinical features such as fever, wasting, lymphadenopathy, hepatosplenomegaly and loss of mobility are often observed.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous lymphoma in children: A report of four cases

Chen

Liu

et al. 2018

Turk J Pediatr

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Chen F, Liu J, Lv Z, Huang Y, Wu Y. Primary cutaneous lymphoma in children: A report of four cases. Turk J Pediatr 2018; 60: 739-743.Primary cutaneous lymphoma (CL) is a malignant lymphoma presenting in the skin. Primary CL is rare in children and difficult to clinically diagnose. We report four pediatric cases of primary CL with tumors in different body area: case 1, on the face and left thigh; case 2, on the left side of the neck; case 3, on the left side of the back; and case 4, on the left buttock. The first diagnoses of these children were rash, abscess, lymphadenitis, and fever, respectively in local hospitals. All 4 patients were diagnosed as primary CL by histopathologic examination in our hospital. Three patients (case 1, case 2 and case 4) were treated with chemotherapy. The size of tumor and degree of cutaneous lesion were alleviated after chemotherapy. Case 3 refused to receive chemotherapy, and died. The cases indicated the importance of early diagnosis of primary CL to guide appropriate therapy.

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Six‐year‐old girl with primary cutaneous aggressive epidermotropic CD8⁺ T‐cell lymphoma

Cited by 19 publications

References 11 publications

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Primary cutaneous CD8+ cytotoxic T‐cell lymphoma involving the epidermis and subcutis in a young child

Primary cutaneous lymphoma in children: A report of four cases

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Six‐year‐old girl with primary cutaneous aggressive epidermotropic CD8+ T‐cell lymphoma

Cited by 19 publications

References 11 publications

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Paediatric cutaneous lymphomas: a review and comparison with adult counterparts

Primary cutaneous CD8+ cytotoxic T‐cell lymphoma involving the epidermis and subcutis in a young child

Primary cutaneous lymphoma in children: A report of four cases

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Six‐year‐old girl with primary cutaneous aggressive epidermotropic CD8⁺ T‐cell lymphoma