Sixty-Five Years of Sympathetic Ophthalmia

Lubin, Jane R.; Albert, Daniel M.; Weinstein, Miriam

doi:10.1016/s0161-6420(80)35270-6

Cited by 229 publications

(24 citation statements)

References 54 publications

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“…Our findings are consistent with previous studies in that the majority of the patients in the study group are men [6, 7]. It is suggested a slight predilection toward males that could be attributed to the increased exposure to trauma.…”

Section: Discussionsupporting

confidence: 93%

“…After the inciting event, traumatic or surgical, intraocular inflammation has been reported in a wide range between 1 week and 66 years, with 80% of the cases occurring within 3 months after injury to the exciting eye and 90% within 1 year [6, 8]. In our group of patients, the patient who developed the disease in the shortest time was within 1 month and the longest time 38 years after injury.…”

Section: Discussionmentioning

confidence: 77%

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Characteristics of Sympathetic Ophthalmia in a Single International Center

Guzman-Salas¹,

Serna‐Ojeda²,

Guinto-Arcos³

et al. 2016

TOOPHTJ

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Aim:To report the main features of sympathetic ophthalmia in a referral ophthalmology center.Methods:Retrospective clinical study. We reviewed clinical records of patients with diagnosis of sympathetic ophthalmia attending the Uveitis Department from 2007 to 2013. Patients were selected by clinical criteria. Descriptive statistics were used to assess variables.Results:Twenty patients were included for analysis, 13 males and 7 females. Mean follow up was 1 year. The median age of presentation was 50 years. Fifty percent had history of ocular trauma and 50% had history of intraocular surgery, of which 40% underwent phacoemulsification. The time between injury and onset of symptoms ranged from 1 to 456 months. Most common ocular manifestations were mutton fat keratic precipitates and anterior chamber inflammation. All patients received oral prednisone as single or combined therapy. Sixty percent of the sympathizing eyes improved two or more lines of vision and 20% lost two or more lines of vision.Conclusion:This report from a single center adds to the body of literature of sympathetic ophthalmia occurring in a specific population. Our data found a high proportion of patients with sympathetic ophthalmia after phacoemulsification.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 77%

Characteristics of Sympathetic Ophthalmia in a Single International Center

Guzman-Salas¹,

Serna‐Ojeda²,

Guinto-Arcos³

et al. 2016

TOOPHTJ

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“…In some specific inflammatory diseases (typically Posner-Schlossman syndrome), active substances of inflammation like prostaglandins and substance P have been implicated as causes of secondary open-angle glaucoma, with important consequences for therapy [1, 4]. Uveitic SG may also be related to trabecular endothelial cell loss secondary to aggressive phagocytic activity and autolysis [16, 17]. Since trabecular meshwork is a part of the uveal tract, it may become directly involved in the inflammatory process (trabeculitis) [18], a putative common mechanism for glaucoma in herpetic uveitis.…”

Section: Discussionmentioning

confidence: 99%

Secondary Glaucoma in Patients with Uveitis

Merayo‐Lloves

Power²,

Rodriguez³

et al. 1999

Ophthalmologica

136

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Purpose: To evaluate the prevalence of secondary glaucoma (SG), clinical forms of uveitis more frequently associated with glaucoma, and describe the treatment and complications encountered in a cohort of patients with glaucoma and uveitis during a 10-year period. Methods: The hospital records of patients with uveitis referred to the Immunology Service of the Massachusetts Eye and Ear Infirmary for a decade were reviewed for cases of SG. Results: One hundred and twenty of the 1,254 patients (9.6%) with uveitis developed SG. SG was more frequent in anterior uveitis (67%) but was also associated with posterior uveitis (13%) and pars planitis (4%). Herpetic keratouveitis (22%), Fuchs’ iridocyclitis (19%), juvenile rheumatoid arthritis-associated iridocyclitis (16%), syphilis (14%), and sarcoidosis (12%) were the leading types of uveitis associated with SG. Despite aggressive medical and surgical therapy, SG was associated with progressive visual field loss and optic nerve damage in 39 patients (33%). Conclusion: SG is an underappreciated, vision-threatening complication in patients with uveitis. Increased vigilance for emergence of this complicating problem during the care of patients with uveitis is warranted, and medical and surgical treatment for reducing IOP should be especially aggressive in these patients. We hypothesize that earlier, more aggressive treatment of uveitis will reduce the presence of glaucoma as an additional vision-robbing complication of uveitis.

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“…Sympathetic ophthalmia (SO) is a bilateral granulomatous uveitis following a penetrating eye injury or repeated intraocular operations. The interval between ocular injury/surgery and the clinical manifestations may vary widely, from a few days to several decades, but 90% of cases occur within one year after the injury [128]. The mechanism is comparable to VKH, auto-sensitivity to an antigenic protein from uveal pigment due to an interruption of the self-tolerance process resulting in bilateral uveitis [129].…”

Section: Sympathetic Ophthalmia (So)mentioning

confidence: 99%

Classification of Non-Infectious and/or Immune Mediated Choroiditis: A Brief Overview of the Essentials

Herbort¹,

Mantovani

Tuğal-Tutkun

et al. 2021

Diagnostics

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The choroid was poorly accessible to imaging investigation until the last decade of the last century. With the availability of more precise imaging methods such as indocyanine green angiography (ICGA) and, later, optical coherence tomography (OCT), enhanced depth OCT (EDI-OCT), and OCT angiography (OCTA), appraisal of choroidal inflammation has substantially gained in accuracy. This allowed to precisely determine which structures were touched in the different non-infectious choroiditis entities and made it possible to classify this group of diseases, ICGA signs, mainly hypofluorescent lesions, were identified and described. Previous publications have divided angiographic findings into two main sets of signs: (1) irregular “geographic” hypofluorescent areas corresponding to choriocapillaris non-perfusion and (2) round more regular, hypofluorescent dark dots more evenly distributed in the fundus corresponding to more deep choroidal stromal foci. These distinct findings allowed to subdivide and classify choroiditis into choriocapillaritis and stromal choroiditis. Additional signs were identified from EDI-OCT and OCTA examination supporting the classification of choroiditis into choriocapillaritis and stromal choroiditis. Results: Diseases involving principally the choriocapillaris included Multiple Evanescent White Dot Syndrome (MEWDS), Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE), Idiopathic Multifocal Choroiditis (MFC), and Serpiginous Choroiditis (SC) as well as mixed forms. Diseases primarily involving the choroidal stroma included HLA-A29 Birdshot Retinochoroiditis (BRC), Vogt-Koyanagi-Harada disease (VKH), Sympathetic Ophthalmia (SO), and Sarcoidosis chorioretinitis (SARC). Thanks to new imaging investigations of the choroid, it is now possible to classify and understand the diverse clinicopathological mechanisms in the group of non-infectious choroiditis entities.

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Sixty-Five Years of Sympathetic Ophthalmia

Cited by 229 publications

References 54 publications

Characteristics of Sympathetic Ophthalmia in a Single International Center

Characteristics of Sympathetic Ophthalmia in a Single International Center

Secondary Glaucoma in Patients with Uveitis

Classification of Non-Infectious and/or Immune Mediated Choroiditis: A Brief Overview of the Essentials

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