Size Analysis of Small Particles in Wet Dispersions by Laser Diffractometry: A Guidance to Quality Data

Cleyn, Elene De; Holm, René; Mooter, Guy Van den

doi:10.1016/j.xphs.2018.12.010

Cited by 19 publications

(5 citation statements)

References 12 publications

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“…Figure 2 B provides more details regarding the size distribution data, fitting, and data quality at 500, 1500, 2500 and 3500 rpm. At the lowest stirring rate, 500 rpm ( Figure 2 B, panel 1), due to agglomeration and heterogenous distribution, the residual and weighted residual values reached >3%, above the recommended threshold of 1–2% [ 25 , 26 ], suggesting unacceptable data quality and unrealistically large particle sizes (e.g., Dv90 > 2500 µm) that were poorly aligned with the light scattering patterns and models. At 1500, 2500, and 3500 rpm ( Figure 2 B, panels 2–4), the distribution curves became smooth and continuous, with the gradual disappearance of the dominant artifact peak (most frequently occurring size > 1000 µm) observed at 500 rpm.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Particle-Size-Based Homogeneity and Mycotoxin Distribution Using Laser Diffraction Particle Size Analysis

Zhang

Tran

Tan

2023

Toxins

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Sample homogeneity dictates whether analyzing a test portion of an entire sample can provide representative information about incurred mycotoxins. In this study, we evaluated particle-size-distribution-based homogeneity of laboratory mycotoxin samples using laser diffraction particle size analysis and International Organization for Standardization (ISO) Guide 35: 2017. Incurred whole corn, compound feed, peanut butter, and wheat flour (500 g each) were comminuted using wet, cryogenic, or dry milling. We used a sample dividing (riffling) device to obtain representative subsamples (25 g each) and developed a laser diffraction particle size analysis procedure by optimizing key parameters such as the refractive index, absorption, and stirring rate. The homogeneity of the particle size distribution within laboratory subsamples was characterized using the optimized laser diffraction procedure. An assessment of homogeneity was also performed for individual mycotoxins in each incurred matrix sample following the procedure described in ISO Guide 35. The concentrations of the incurred mycotoxins were determined using liquid chromatography–mass spectrometry (LC-MS). Within- and between-subsample variances of incurred aflatoxin B1 in peanut butter; deoxynivalenol in corn, compound feed, and wheat flour; and fumonisins in compound feed corroborated that when the particle size measurements were less than 850 µm, mycotoxins concentrations were consistent across independent test portions, which was confirmed using an analysis of variance (F-test). This study highlights the benefits of laser diffraction particle size analysis and suggests its use as a test procedure to evaluate homogeneity in new sample commodities.

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Section: Resultsmentioning

confidence: 99%

Characterization of Particle-Size-Based Homogeneity and Mycotoxin Distribution Using Laser Diffraction Particle Size Analysis

Zhang

Tran

Tan

2023

Toxins

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“…Although microscopy did not identify the smaller particles, it did result in lower mean particle sizes in the PCPs compared to laser diffraction with the CILAS data (Table 3). It has been reported that microscopy tends to result in smaller particle size value averages compared to laser diffraction techniques, as a consequence of the different physical properties of the particles being measured and the magnification of the microscope used (De Cleyn et al 2019).…”

Section: Resultsmentioning

confidence: 99%

A Comparison of Different Approaches for Characterizing Microplastics in Selected Personal Care Products

Renner

Foster

Routledge

et al. 2021

Environmental Toxicology and Chemistry

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Any uncertainty in determining numbers of microplastics in the environment may be a barrier to assessing their impact and may stem from various aspects of methodologies used to quantify them. We undertook a comparison of approaches to quantify and characterize microplastics in 4 personal care products. The aim was not only to determine how many particles were present but to assess any differences due to the methods used. Counting of extracted microplastics was undertaken using particle size analysis, light microscopy, and imaging flow cytometry. Micro-Fourier transform infrared spectroscopy (µ-FTIR) was used to characterize the particles in each product. The mean size distribution of microplastics differed depending on the method employed, and it was apparent that imaging flow cytometry was affected by high background noise that may require staining of plastics to overcome. The application of µ-FTIR confirmed polyethylene as the microplastic in each product. Methodological challenges encountered in the study and the literature have highlighted the need for standardization of methods for determining microplastics.

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“…This complex analysis was done to ensure the most accurate particle size determinations possible. Method suitability was confirmed my measuring the particle size of a suspension added to the dispersion media over 10 min, which produced similar particle size distributions for all three compounds and the obtained sizes of particles were reanalyzed if air bubbles occurred as peaks in the particle size distribution to exclude those from the measurements [17].…”

Section: Particle Size Measurements By Laser Diffractionmentioning

confidence: 99%

“…1), in particular at compression pressures above 75 MPa. Plastic materials tend to form tablets more easily due to increased bonding strength across the particles as compared to fragmenting materials [17,30,31]; [21][22][23][24]), which provided indications of the mechanical properties of the investigated compounds. These were furthermore supported by the changes in particle size distributions of recovered particles that were observed with increased compression pressures during tableting (Fig.…”

Section: Deformation Propertiesmentioning

confidence: 99%

Impact of Drug Compounds Mechanical/Deformation Properties on the Preparation of Nano- and Microsuspensions

Zulbeari,

Hansen,

Morgen

et al. 2023

Preprint

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Size Analysis of Small Particles in Wet Dispersions by Laser Diffractometry: A Guidance to Quality Data

Cited by 19 publications

References 12 publications

Characterization of Particle-Size-Based Homogeneity and Mycotoxin Distribution Using Laser Diffraction Particle Size Analysis

Characterization of Particle-Size-Based Homogeneity and Mycotoxin Distribution Using Laser Diffraction Particle Size Analysis

A Comparison of Different Approaches for Characterizing Microplastics in Selected Personal Care Products

Impact of Drug Compounds Mechanical/Deformation Properties on the Preparation of Nano- and Microsuspensions

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