Size and motion of the mitral valve annulus in anesthetized intact dogs.

Tsakiris, Anastasios G.; Bernuth, G. von; Rastelli, G.C.; Bourgeois, M.; Titus, Jack L.; Wood, Earl H.

doi:10.1152/jappl.1971.30.5.611

Cited by 175 publications

(84 citation statements)

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“…The magnitude of the annulus excursion and left atrial area change is related to the degree of ventricular emptying. 23,26 In the present study, there was a linear correlation between cardiac output and the velocity of systolic forward flow.…”

Section: Overall Relation Of Hemodynamics To Doppler Velocitiessupporting

confidence: 58%

Relation of pulmonary vein to mitral flow velocities by transesophageal Doppler echocardiography. Effect of different loading conditions.

et al. 1990

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It has previously been demonstrated that predictable changes occur in mitral flow velocities under different loading conditions. The purpose of this study was to relate changes in pulmonary venous and mitral flow velocities during different loading conditions as assessed by transesophageal echocardiography in the operating room. Nineteen patients had measurements of hemodynamics, that is, mitral and pulmonary vein flow velocities during the control situation, a decrease in preload by administration of nitroglycerin, an increase in preload by administration of fluids, and an increase in afterload by infusion of phenylephrine. There was a direct correlation between the changes in the mitral E velocity and the early peak diastolic velocity in the pulmonary vein curves (r=0.61) as well as a direct correlation between the deceleration time of the mitral and pulmonary venous flow velocities in early diastole (r=0.84).This indicates that diastolic flow velocity in the pulmonary vein is determined by the same factors that influence the mitral flow velocity curves. A decrease in preload caused a significant reduction in the initial E velocity and prolongation of deceleration time, and an increase in preload caused an increase in E velocity and shortening of deceleration time. An increase in afterload produced a variable effect on the initial E velocity and deceleration time and was dependent on the left ventricular filling pressure. The change in systolic forward flow velocity in the pulmonary vein was directly proportional to the change in cardiac output (r=0.60). The pulmonary capillary wedge pressure correlated best with the flow velocity reversal in the pulmonary vein at atrial contraction (r=0.81). Use of pulmonary vein velocities in conjunction with mitral flow velocities can help in understanding left ventricular filling. (Circulation 1990;81:1488-1497 Abnormalities of diastolic function of the heart play an integral role in many disease entities.'2 Because of the complexity of the multiple, interrelated processes contributing to diastolic function, there is no clinical tool available for its assessment.3 It has been proposed that Doppler echocardiography might provide information concerning diastole because of its ability to noninvasively measure blood flow velocities across the mitral valve.45 We, as well as others,6-9 previously demonstrated that predictable changes occur in the mitral flow velocities under different loading conditions. This has resulted in understanding the significance of changes in these velocities and has allowed the development of a conceptual framework for interpretation of the various velocity curves.'0 Pulmonary vein velocities have recently been used in conjunction with mitral flow velocities to increase our understanding of ventricular filling.11-13 However, because of the location of the pulmonary vein in the far field from a precordial apical window, it can be difficult to place the sample volume within the pulmonary vein to obtain the true velocities through the pulmonary vein. Th...

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Section: Overall Relation Of Hemodynamics To Doppler Velocitiessupporting

confidence: 58%

Relation of pulmonary vein to mitral flow velocities by transesophageal Doppler echocardiography. Effect of different loading conditions.

et al. 1990

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“…9 Dynamic imaging coupled with quantitative software demonstrated the dynamic nature of mitral annulus physiology in normal humans, 8,9 matching the old observations in animals. 10 In contrast, we found DMVD annulus generally of abnormal dynamics, 9 but no analysis of Mitral Dynamics in DMVD DMVD phenotypes for annular or valvular dynamics has been reported. New progress in quantitative methods now allow measurement of mitral annulus, leaflets, and prolapse dimensions, 11 and yield the new possibility of complete dynamic characterization of these DMVD phenotypes.…”

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confidence: 62%

Dynamic Phenotypes of Degenerative Myxomatous Mitral Valve Disease

Clavel

Mantovani

Malouf

et al. 2015

Circ: Cardiovascular Imaging

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Background-Fibro-elastic deficiency (FED) and diffuse myxomatous degeneration (DMD) are phenotypes of degenerative mitral valve disease defined morphologically. Whether physiological differences in annular and valvular dynamics exist between these phenotypes remains unknown. Methods and Results-We performed triple quantitation of cardiac remodeling and of mitral regurgitation severity and of annular and valvular dimensions by real-time 3-dimensional-transesophageal-echocardiography. Forty-nine patients with degenerative mitral valve disease classified as FED (n=31)

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“…Concerning the size and motion of the normal mitral valve, detailed investigations have been done in autopsy specimens and through echocardiography, [11][12][13][14][15][16][17][18][19][20] and it has been demonstrated that the mitral valve diameter of a normal heart shows a logarithmic correlation with BSA. 14,15 In our present study, the observed diameter [DM (Obs)] of many cadaveric hearts was larger than one predicted according to Rowlatt's criterion [DM (Prd)] (p<0.0001; paired t-test) ( Table 2, Fig 3).…”

Section: Discussionmentioning

confidence: 99%