2016
DOI: 10.1155/2016/5946520
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Size and Proportions of Slow-Twitch and Fast-Twitch Muscle Fibers in Human Costal Diaphragm

Abstract: Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). Diaphragmatic fibers were smaller than fibers in vastus lateralis with regard to the mean minimal fiber diameter of sl… Show more

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Cited by 18 publications
(18 citation statements)
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“…Males tend to have greater facial length than females 34 . Moreover, the diameters of type II muscle fibres are larger than type I 35 , and there is a higher portion of type II muscle fibres in male masseters as compared to those of female 34 .…”
Section: Intra-rater Icc (95% Ci)mentioning
confidence: 95%
“…Males tend to have greater facial length than females 34 . Moreover, the diameters of type II muscle fibres are larger than type I 35 , and there is a higher portion of type II muscle fibres in male masseters as compared to those of female 34 .…”
Section: Intra-rater Icc (95% Ci)mentioning
confidence: 95%
“…Muscle fiber cross‐sectional area (CSA) and the numerical proportions of slow‐MyHC were calculated using an ImageJ 1.43 analyzing system, respectively. On average, 150 muscle fibers were analyzed in each sample of red gastrocnemius as described in previous studies …”
Section: Methodsmentioning
confidence: 99%
“…On average, 150 muscle fibers were analyzed in each sample of red gastrocnemius as described in previous studies. [34,35]…”
Section: Immunohistochemistry For Fiber Type and Cross-sectional Areamentioning
confidence: 99%
“…Another possible hypothesis is the diaphragm muscle fibre phenotype of approximately 76% slow-twitch oxidative and fast oxidative fibres, suggesting greater muscle reserve [46]. Moreover, the smaller diameter and cross-sectional area of the diaphragm compared with other muscles [47], reduces the exchange distance with the capillary and promotes a more efficient oxygen supply; these factors could be responsible for the increased diaphragm resistance to fatigue. According to the literature reports, the most reasonable independent variables for explaining TLC and FVC were right diaphragmatic thickness in maximal expiration and right diaphragmatic movement during deep breathing.…”
Section: Discussionmentioning
confidence: 99%