Size- and shape-dependent cytotoxicity of nano-sized Zr-based porphyrinic metal-organic frameworks to macrophages

Fang, Hao; Yan, Zhu‐Ying; Yan, Xiu‐Ping

doi:10.1016/j.scitotenv.2022.155309

Cited by 12 publications

(7 citation statements)

References 62 publications

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“…[31,54] Owing to the large surface areas, highly ordered porosity, and well-defined structures, nMOFs will have promising ability of loading and releasing for therapeutic agents. In consideration of biocompatibility, the most often studied nMOFs are Materials of the Institute Lavoisier (MIL), [55] zeolitic imidazolate frameworks (ZIFs), [56] porous coordination networks (PCNs), [57] and University of Oslo nanoparticles. [58,59] Among many nanoformulations, nMOFs have emerged as a unique class of inorganic-organic hybrid nanomaterials with several favorable attributes for biological applications owing to excellent biocompatibility, biodegradability, suitable size, ease of modification, and functionalization.…”

Section: Nmofs For Cancer Immunotherapymentioning

confidence: 99%

“…[ 31,54 ] Owing to the large surface areas, highly ordered porosity, and well‐defined structures, nMOFs will have promising ability of loading and releasing for therapeutic agents. In consideration of biocompatibility, the most often studied nMOFs are Materials of the Institute Lavoisier (MIL), [ 55 ] zeolitic imidazolate frameworks (ZIFs), [ 56 ] porous coordination networks (PCNs), [ 57 ] and University of Oslo nanoparticles. [ 58,59 ]…”

Section: Nmofs For Cancer Immunotherapymentioning

confidence: 99%

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Hybrid Nanomaterials for Cancer Immunotherapy

Yang

et al. 2022

Advanced Science

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Nano-immunotherapy has been recognized as a highly promising strategy for cancer treatment in recent decades, which combines nanotechnology and immunotherapy to combat against tumors. Hybrid nanomaterials consisting of at least two constituents with distinct compositions and properties, usually organic and inorganic, have been engineered with integrated functions and enormous potential in boosting cancer immunotherapy. This review provides a summary of hybrid nanomaterials reported for cancer immunotherapy, including nanoscale metal-organic frameworks, metal-phenolic networks, mesoporous organosilica nanoparticles, metallofullerene nanomaterials, polymer-lipid, and biomacromolecule-based hybrid nanomaterials. The combination of immunotherapy with chemotherapy, chemodynamic therapy, radiotherapy, radiodynamic therapy, photothermal therapy, photodynamic therapy, and sonodynamic therapy based on hybrid nanomaterials is also discussed. Finally, the current challenges and the prospects for designing hybrid nanomaterials and their application in cancer immunotherapy are outlined.

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Section: Nmofs For Cancer Immunotherapymentioning

confidence: 99%

Section: Nmofs For Cancer Immunotherapymentioning

confidence: 99%

Hybrid Nanomaterials for Cancer Immunotherapy

Yang

et al. 2022

Advanced Science

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“…[ 76 ] Subsequently, Yan's group evaluated the dark toxicity of 30, 90, and 180 nm PCN‐224. [ 77 ] The results showed that smaller PCN‐224 gave higher cytotoxicity due to the stronger phospholipid adsorption and higher cellular dissolution, which induced significant cell necrosis ( Figure ).…”

Section: Key Factors Affecting the Cytotoxicity Of Mofsmentioning

confidence: 99%

“…One example for this effect was reported by Yan's group. [ 82 ] They synthesized spherical PCN‐224 and rod‐shape PCN‐222 with the same building blocks (Zr nodes and meso‐tetra(4‐carboxyphenyl) porphyrin) and similar hydrodynamic sizes. PCN‐224 gave stronger inhibition of cell viability and higher rate of cell necrosis than PCN‐222.…”

Section: Key Factors Affecting the Cytotoxicity Of Mofsmentioning

confidence: 99%

“…C) Relative content of ROS in J774A.1 cells treated with 30 nm PCN-224 compared with negative control (PBS-treated cells) at 2, 4, and 6 h. D) LSCM images of activated caspase 3/7 in J774A.1 cells after treatment with 30 nm PCN-224 (20 and 50 nM) for 12 h. Scale bars, 20 μm. E) Viability of J774A.1 cells treated with 30 nm PCN-224 (20 nM) for 24 h with or without caspase inhibitor Z-VAD-FMK (20 μM).Reproduced with permission [77]. Copyright 2022, Elsevier.…”

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confidence: 99%

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Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

Fang

Yan

2022

Small Science

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Reticular chemistry has become a powerful tool for scientists to design crystalline porous materials with different fundamental units. [1] Over the past decades, porous materials have gained great attention due to their outstanding performance and wide applications. Among various porous materials, the combination of metal nodes and organic linkers by coordination bonds creates new hybrid porous materials called metal-organic frameworks (MOFs) and opens a new window in the design of porous materials.Since the first report on MOFs by Yaghi's group in 1995, [2] more than 100 000 kinds of MOFs have been synthesized according to the Cambridge Structural Database (CSD). The unique characteristics, including tunable porosity, customized chemical composition, large specific surface area, and easy functionalization, make MOFs promising candidates for numerous applications in diverse fields such as gas storage and separation, catalysis, sensing, adsorption, energy, and biomedical sciences. [3] In addition, the large-scale production and commercialization of MOFs began from 2016. [4] For instance, the commercial MOF adsorbent for storage of 1-methylcyclopropene to ripen vegetables and fruits was driven to the market. [5] The Numat's ION-X gas cylinder was designed based on the MOF adsorbent to store hazardous gases for semiconductor industry, showing significant advantages over traditional adsorbents. [3a] Apart from the commercialization in gas storage, the MOF-303-based apparatus has been used to collect water in the desert. [6] Despite the advantages of MOFs, the wide application of MOFs has led to environmental health risks. The accidental release of MOF particles into the environment from their bulk-products is inevitable during the lifecycle of MOFs. The deposition, decomposition, and distribution of released MOFs in environmental media could result in the exposure to humans and other organisms, inducing various biological effects. In addition, the intentional administration of MOFs in biomedicine (such as bioimaging, drug delivery system) also leads to the exposure risks to humans. Under these circumstances, the environmental health risks of MOFs are unavoidable.The toxicity of MOFs plays an important role in their health risk assessment. Compared with in vivo and ex vivo toxicity assessments, in vitro toxicity evaluation based on cell culture is low cost, fast, and high throughput, making it an ideal model in toxicity research. As the basic unit in organism, cells play an important role in life activity. The toxic effects on cells would affect their function and therefore induce significant response

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Metal-organic framework-based nanoarchitectonics: A promising material platform for electrochemical detection of organophosphorus pesticides

Huang,

Wu,

et al. 2024

Coordination Chemistry Reviews

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Size- and shape-dependent cytotoxicity of nano-sized Zr-based porphyrinic metal-organic frameworks to macrophages

Cited by 12 publications

References 62 publications

Hybrid Nanomaterials for Cancer Immunotherapy

Hybrid Nanomaterials for Cancer Immunotherapy

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

Metal-organic framework-based nanoarchitectonics: A promising material platform for electrochemical detection of organophosphorus pesticides

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