Size and Shape of Associations of OGTT as Well as Mediating Effects on Adverse Pregnancy Outcomes Among Women With Gestational Diabetes Mellitus: Population-Based Study From Southern Han Chinese

Zhou, Zixing; Chen, Gengdong; Fan, Dazhi; Rao, Jiaming; Li, Pengsheng; Wu, Shuzhen; Lin, Dongxin; Ma, Huiting; Ye, Shaoxin; Zhang, Huishan; Shen, Xiuyin; Wan, Yingchun; Luo, Xinrong; Suo, Dongmei; Guo, Xiaoling; Liu, Zheng­ping

doi:10.3389/fendo.2020.00135

Cited by 12 publications

(9 citation statements)

References 32 publications

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“…In the present study, the association between HbA1c and the risk of primary C-section varied in different pre-pregnancy BMI groups and maternal age groups. Studies have revealed the utility of HbA1c as a biomarker for predicting C-sections ( 39 ). Meanwhile, our results also indicated that normal-weight women with HbA1c levels≥5.5% (37mmol/mol) and underweight women with HbA1c 5.1%-5.4% (32mmol/mol – 36mmol/mol) had an increased risk of primary C-section.…”

Section: Discussionmentioning

confidence: 99%

The association between maternal HbA1c and adverse outcomes in gestational diabetes

Muhuza

Zhang

et al. 2023

Front. Endocrinol.

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BackgroundThe role of HbA1c in women with gestational diabetes mellitus (GDM) is still unclear, particularly in the Asian population.AimTo investigate the association between HbA1c levels and adverse outcomes considering maternal age, pre-pregnancy body mass index (BMI), and gestational weight gain (GWG) in women with GDM.MethodA retrospective study included 2048 women with GDM and singleton live births. Using logistic regression, the associations between HbA1c and adverse pregnancy outcomes were assessed.ResultCompared to women with HbA1c ≤ 5.0%, HbA1c was significantly associated with macrosomia (aOR 2.63,95%CI1.61,4.31), pregnancy-induced hypertension (PIH, aOR 2.56,95%CI1.57,4.19), preterm birth (aOR 1.64,95%CI 1.05,2.55), and primary Cesarean section (primary C-section, aOR1.49,95%CI1.09,2.03) in GDM women with HbA1c ≥5.5% while significantly associated with PIH (aOR 1.91,95%CI1.24,2.94) in women with HbA1c 5.1-5.4%. The associations between HbA1c and adverse outcomes varied with maternal age, pre-pregnancy BMI, and GWG. In women aged ≤29 years, there’s significant association between HbA1c and primary C-section when HbA1c was 5.1-5.4% and ≥5.5%. In women aged 29-34 years and HbA1c ≥5.5%, HbA1c was significantly associated with macrosomia. In women aged ≥35 years, there’s significant association between HbA1c and preterm birth when HbA1c was 5.1-5.4% and macrosomia and PIH when HbA1c ≥5.5%. In pre-pregnant normal-weight women, HbA1c was significantly associated with macrosomia, preterm birth, primary C-section, and PIH when HbA1c ≥5.5% while HbA1c was significantly associated with PIH when HbA1c was 5.1-5.4% . In pre-pregnant underweight women with HbA1c 5.1-5.4%, HbA1c was significantly associated with primary C-section. HbA1c was significantly associated with macrosomia among women with inadequate GWG or excess GWG and HbA1c≥5.5%. In women with adequate GWG, there’s significant association between HbA1c and PIH when HbA1c was 5.1-5.4% and ≥5.5% .ConclusionConclusively, HbA1c at the time of diagnosis is significantly associated with macrosomia, preterm birth, PIH, and primary C-section in Chinese women with GDM.

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Section: Discussionmentioning

confidence: 99%

The association between maternal HbA1c and adverse outcomes in gestational diabetes

Muhuza

Zhang

et al. 2023

Front. Endocrinol.

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“…This is consistent with Chatzakis et al [10], who found an increased risk of high birth weight in patients with abnormal fasting glucose only. Relevant studies are consistent with this conclusion, Sesmilo G et al [4] con rmed FPG is an early marker of GDM, Zhou Zet al [11] demonstrated higher FPG was more strongly linked to adverse pregnancy outcomes among GDM patients, both linearity and Non-linearity of associations between glucose and complications should be taken into account.…”

Section: Discussionmentioning

confidence: 59%

The oral glucose tolerance test and short-term adverse outcomes among patients with gestational diabetes mellitus

Geng¹,

Li²,

Qian³

et al. 2023

Preprint

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Objective To investigate the relationship between oral glucose tolerance test (OGTT) findings and short-term adverse pregnancy outcomes among women with gestational diabetes mellitus. Methods We retrospectively collected 387 cases of pregnant womenwith gestational diabetes mellitus from 2020 to 2021 at the Maternity & Child Care Center of Dezhou and analyzed laboratory results. According to OGTT values, patients were divided into three groups, and pregnancy outcomes were analyzed; these included gestational weight gain, gestational hypertension, cesarean section, preterm birth, dead fetus, fetal distress, fetal growth restriction, congenital disabilities, macrosomia, and low birth weight. In group 1, 277 patients had abnormal OGTT values, and short-term adverse outcomes were studied. Results Three abnormal OGTT points were accompanied by significant gestational weight gain, gestational hypertension incidence, and low birth weight incidence; the risks of cesarean section and preterm birth increased. Abnormal fasting plasma glucose was associated with gestational hypertension. Conclusion OGTT findings can be used to alert clinicians to short-term adverse outcomes in mothers and infants. Clinicians should be aware of abnormal OGTT findings.

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“…Although there are no uniform conclusions about the specific mechanisms underlying this association, there may be a bidirectional link between anxiety or depression and hyperglycemia (Pan et al, 2010). A higher OGTT value is strongly associated with a higher degree of insulin resistance (Ghio et al, 2012) and a higher risk of adverse pregnancy complications (Zhou et al, 2020), both related to mental health disorders (Rustad et al, 2011). More clinical research is needed to confirm this relationship's potential mechanisms further.…”

Section: Discussionmentioning

confidence: 99%

Predictors of anxiety among pregnant women with gestational diabetes mellitus and their partners: The mediating role of marital satisfaction

Han

Xiang

Zhang

et al. 2023

Int J of Nursing Practice

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AimsThis study aims to examine the prevalence of anxiety symptoms and identify predictors of anxiety among pregnant women with gestational diabetes mellitus and their partners and explore the mediating role of marital satisfaction between maternal and paternal anxiety.DesignA cross‐sectional study was conducted in Guangzhou, China, from July 2021 to May 2022.MethodsA total of 306 dyads of pregnant women with gestational diabetes mellitus and their partners completed the State–Trait Anxiety Inventory, Locke–Wallace Marital Adjustment Test and the socio‐demographic and clinical data sheet.ResultsThe prevalence of anxiety symptoms was 32.4% and 36.6% in pregnant women with gestational diabetes mellitus and their partners, respectively. The predictors of maternal anxiety were paternal anxiety, maternal marital satisfaction, maternal monthly salary, fasting glucose value and 1‐h glucose value. By contrast, the predictors of paternal anxiety were maternal anxiety, paternal marital satisfaction and paternal monthly salary. Moreover, the relationship between maternal and paternal anxiety was mediated by marital satisfaction.ConclusionsThe anxiety symptoms of pregnant women with gestational diabetes mellitus and their partners influence each other, and this relationship was mediated by marital satisfaction. Every couple should be screened for anxiety symptoms and treated as a team rather than focusing solely on the pregnant woman.

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Size and Shape of Associations of OGTT as Well as Mediating Effects on Adverse Pregnancy Outcomes Among Women With Gestational Diabetes Mellitus: Population-Based Study From Southern Han Chinese

Cited by 12 publications

References 32 publications

The association between maternal HbA1c and adverse outcomes in gestational diabetes

The association between maternal HbA1c and adverse outcomes in gestational diabetes

The oral glucose tolerance test and short-term adverse outcomes among patients with gestational diabetes mellitus

Predictors of anxiety among pregnant women with gestational diabetes mellitus and their partners: The mediating role of marital satisfaction

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