Size controlled synthesis of starch nanoparticles by a simple nanoprecipitation method

Abstract

Starch nanoparticles of particle size range between 300 nm and 400 nm were synthesized by a simple nanoprecipitation method from native sago starch (Metroxylon sagu). Starch nanoparticles were formed by controlled precipitation through drop-wise addition of dissolved native starch solution to excess absolute ethanol. The size and shape of starch nanoparticles were modulated varying the synthesis parameters including the use of appropriate surfactant. Starch nanoparticles with mean diameter of about 150 nm were obtained in the presence of surfactants during precipitation. Both solvent and non-solvent systems used in the synthesis method were aqueous-based and the method was facile, and easy to perform as compared to other synthesis approaches previously reported.

Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

“…Besides their unique benefi ts, liposomes show some disadvantages such as low stability, low encapsulation effi ciency, high cost of manufacturing, degradation by hydrolysis or oxidation, sedimentation, aggregation or fusion during storage (18). Thus, other natural polymers based on polysaccharides have been tested as delivery systems for antimicrobial agents (19,20).…”

“…Alginate, chitosan and starch particles were prepared by the emulsifi cation method based on gelation and cross-linking of polymers (15,19,20). Sodium alginate is a water-soluble polymer that forms a gel in the presence of multivalent cations such as calcium.…”

“…Methods proposed to prepare chitosan nanoparticles are based on the spontaneous formation of complexes between chitosan and polyanions such as tripolyphosphate (19). Starch nanoparticles were formed using simple, fast and easy method of nanoprecipitation in absolute ethanol under controlled conditions (20).…”

Optimizing Delivery Characteristics of Curcumin as a Model Drug via Tailoring Mean Diameter Ranges of Cellulose Beads

“…At low cellulose solution concentration, cellulose molecules would undergo complete nucleation process which resulted in the precipitation of nCBs in a more dispersed state [24,42]. As the concentration of cellulose solution was increased, the Ostwald ripening effect would lead to the formation of larger cellulose beads which grew at the expense of smaller cellulose beads [25]. Besides, the hydrophilic nature of cellulose molecules would lead to aggregation through hydrogen bonding between smaller cellulose to form larger cellulose beads [43].…”

“…On the other hand, the nanoprecipitation (or solvent displacement) process could be used for the fabrication of cellulose particles of desirable particle size distributions via manipulating the synthesis parameters [24]. Due to its simplicity and reproducibility, the nanoprecipitation process is a favourable approach for the fabrication of nanosized cellulose beads [22,25].…”