Size-Dependent Protein Adsorption on a Nanoparticle

Canpolat, Çetin; Tatlisöz, Mehmet Melih

doi:10.1109/tnb.2022.3219926

Cited by 1 publication

(2 citation statements)

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“…Due to the different curvatures leading to the inhomogeneous charge distribution, the surface charge density is affected by nanotopographical dimensions, 34 subsequeny influencing the FN adsorption. The influence of nanoconvex diameter on FN adsorption was investigated.…”

Section: Coulomb's Force Analysis Of Nanoconvex Surfaces With Differe...mentioning

confidence: 99%

“…The different adsorption mechanisms between nanoconvex and nanoconcave surfaces have been demonstrated in previous work, which further influence the human osteoblast adhesion. 30 Regards the adsorption mechanisms, Canpolat and Tatlisoz 34 presented a model for protein adsorption within a charged silica nanoparticle with an electrical double layer using finite element analysis. Atif et al 35 used a Langmuir isotherm-based model to characterize protein and cell adhesion on a biomimetic hydroxyapatite surface.…”

Section: Introductionmentioning

confidence: 99%

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Theoretical modeling approach for adsorption of fibronectin on the nanotopographical implants

Gao,

Zhao,

Wang

et al. 2023

Proc Inst Mech Eng H

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The success of orthopedic implants depends on the sufficient integration between tissue and implant, which is influenced by the cellular responses to their microenvironment. The conformation of adsorbed extracellular matrix is crucial for cellular behavior instruction via manipulating the physiochemical features of materials. To investigate the electrostatic adsorption mechanism of fibronectin on nanotopographies, a theoretical model was established to determine surface charge density and Coulomb’s force of nanotopography – fibronectin interactions using a Laplace equation satisfying the boundary conditions. Surface charge density distribution of nanotopographies with multiple random fibronectin was simulated based on random number and Monte Carlo hypothesis. The surface charge density on the nanotopographies was compared to the experimental measurements, to verify the effectiveness of the theoretical model. The model was implemented to calculate the Coulomb force generated by nanotopographies to compare the fibronectin adsorption. This model has revealed the multiple random quantitative fibronectin electrostatic adsorption to the nanotopographies, which is beneficial for orthopedic implant surface design. Significance: The conformation and distribution of adsorbed extracellular matrix on biomedical implants are crucial for directing cellular behaviors. However, the Ti nanotopography-ECM interaction mechanism remains largely unknown. This is mostly because of the interactions that are driven by electrostatic force, and any experimental probe could interfere with the electric field between the charged protein and Ti surface. A theoretical model is hereby proposed to simulate the adsorption between nanotopographies and fibronectin. Random number and Monte Carlo hypothesis were applied for multiple random fibronectin simulation, and the Coulomb’s force between nanoconvex and nanoconcave structures was comparatively analyzed.

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Section: Coulomb's Force Analysis Of Nanoconvex Surfaces With Differe...mentioning

confidence: 99%