Size-induced segregation during die filling

Zakhvatayeva, Anastasiya; Hare, Colin; Wu, Chuan‐Yu

doi:10.1016/j.ijpx.2019.100032

Cited by 2 publications

(6 citation statements)

References 21 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degree of segregation was calculated using Equation ( 6 ) where the segregation index indicates the level of uniformity in the powder blend in the die. Although the conclusion in Zakhvatayeva et al’s [ 109 ] study is that suction filling improves die-filling efficiency and reduces segregation, in Figure 22 it is seen that gravitation filling with a fast die-filling velocity had a lower segregation index compared to suction filling. However, the slow die-filling velocity may not be representative of a real-life scenario in industry.…”

Section: Tablettingmentioning

confidence: 88%

“…(Lower surface energy will mean that powder will find it more difficult to form strong interparticle bonds [ 103 , 108 ]), which all contribute to improved flowability [ 27 , 38 , 107 ]. To have content uniformity, the segregation must be kept to a minimum during the die-filling stage so as not to undo the work done during the mixing stage [ 107 , 109 ]. This section will focus on the die fill performance where the mass, segregation and fill depth are important to ensure the compression process will be successful.…”

Section: Tablettingmentioning

confidence: 99%

“…However, the presence of air can also create an adverse pressure gradient which resists the motion of particles, and pressure built up can further oppose the flow of the powder [ 27 ]. Suction filling has also seen positive effects with overcoming poorly flowable powders [ 38 , 106 , 109 , 119 ] and helps with the air entrapment which hinders powder flow as it creates a negative pressure gradient [ 38 , 107 ]. Furthermore, suction fill is generally known to lower the risk of segregation and improve the packing density [ 38 ].…”

Section: Tablettingmentioning

confidence: 99%

“… Segregation index of three different blends of Acetylsalicylic acid (ASA) with mannitol using gravity and suction filling where suction filling mostly has a lower segregation index compared to gravity from Zakhvatayeva et al [ 109 ] the fast scenario is where the die-filling velocity is 260 mm/s and slow has a die-filling velocity of 70 mm/s. …”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

et al. 2023

View full text Add to dashboard Cite

The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number of unit operations or handling steps. Due to the nature of continuous processing, the bulk properties of the formulation will require sufficient flowability and tabletability in order to be processed and transported effectively to and from each unit operation. Powder cohesion presents one of the greatest obstacles to the CDC process as it inhibits powder flow. As a result, there have been many studies investigating potential manners in which to overcome the effects of cohesion with, to date, little consideration of how these controls may affect downstream unit operations. The aim of this literature review is to explore and consolidate this literature, considering the impact of powder cohesion and cohesion control measures on the three-unit operations of the CDC process (feeding, mixing, and tabletting). This review will also cover the consequences of implementing such control measures whilst highlighting subject matter which could be of value for future research to better understand how to manage cohesive powders for CDC manufacture.

show abstract

Section: Tablettingmentioning

confidence: 88%

Section: Tablettingmentioning

confidence: 99%

Section: Tablettingmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Accordingly, suction fill conditions eliminated this vertical segregation. On the other hand, the horizontal distribution of ingredients was uneven regardless of the presence of air, but no clear trend was found [62].…”

Section: Studies On Segregation In Stationary Die and Moving Shoementioning

confidence: 89%

Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

Jakubowska

Ciepluch

2021

Pharmaceutics

View full text Add to dashboard Cite

Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend homogeneity, or may result from further particle segregation during storage, transfer or the compression process itself. This review presents the most relevant powder segregation mechanisms in tablet manufacturing and summarizes the currently available, up-to-date research on segregation and uniformity loss at the various stages of production process—the blend transfer from the bulk container to the tablet press, filling and discharge from the feeding hopper, as well as die filling. Formulation and processing factors affecting the occurrence of segregation and tablets’ CU are reviewed and recommendations for minimizing the risk of content uniformity failure in tablets are considered herein, including the perspective of continuous manufacturing.

show abstract

Size-induced segregation during die filling

Abstract: Graphical abstract

Cited by 2 publications

References 21 publications

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

Contact Info

Product

Resources

About