Size mapping of electric field-assisted production of polycaprolactone particles

Enayati, Marjan; Ahmad, Zeeshan; Stride, Eleanor; Edirisinghe, Mohan

doi:10.1098/rsif.2010.0099.focus

Cited by 51 publications

(50 citation statements)

References 42 publications

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“…18,24 Both microspheres (2 mg prepared with 5 and 10 wt% of daidzein) and coatings were soaked into 1 ml medium in a cellulose dialysis bag (Spectra/Por s 1, molecular weight cutoff 6000 to 8000, Carl Roth, Germany). Then the dialysis bag was put into a plastic tube and filled with another 4 ml of releasing medium.…”

Section: Drug Release Studymentioning

confidence: 99%

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Chen

Yao

et al. 2016

J. Mater. Chem. B

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The development of drug delivery coating systems for local and long-term drug release is gaining increasing interest especially to functionalize bioinert implants with osseointegration and antibacterial properties. In this study, a biodegradable drug delivery coating platform consisting of drug-loaded PHBV microspheres embedded in an alginate-PVA matrix was fabricated by a one-step electrophoretic deposition (EPD) process. Layer by layer (LbL) deposition was exploited to generate chitosan-alginate multilayers on the EPD-produced coating to enlarge the diffusional barrier around the microspheres for controlled drug release. Daidzein, selected as a model drug due to its anti-osteoporosis properties, was pre-encapsulated in PHBV microspheres. The parameters for microsphere fabrication were optimized by an orthogonal design approach. The loading efficiency of daidzein in both the microspheres and in the deposited coatings was adjusted by varying the processing parameters during microsphere fabrication and the EPD process. The degradation of the deposited multilayers was investigated in PBS for up to 14 days. The degradation rate, surface roughness and wettability, as well as adhesion strength of the coatings during degradation were evaluated by applying a range of techniques. A controlled and sustained daidzein release was detected from both free microspheres and microsphere-containing coatings. Finally cytotoxicity and stimulatory effects of daidzein or daidzein-loaded coatings, on both MC3T3-E1 and RAW264.7 cell lines, were studied to validate the potential of the developed coatings for orthopedic applications.

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Section: Drug Release Studymentioning

confidence: 99%

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Chen

Yao

et al. 2016

J. Mater. Chem. B

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“…For instances, size and morphology of poly(lactic/glycolic) acid (PLGA) particles were controlled by adjusting solvent, molecular weight, nozzle diameter and flow rate as these studies of Yao [5], Meng [6] and JafariNodoushan [7]. Other polymers were used to fabricate electrosprayed microspheres with homogeneous and stable morphology such as chitosan [8,9], polylactide acid (PLA) and PCL (Polycaprolactone) [1, 10,11].…”

Section: Introductionmentioning

confidence: 99%

Electrospray Method: Processing Parameters Influence on Morphology and Size of PCL Particles

Nguyen Vu

2018

JST

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The polymeric microparticles using electrospray technique have been used effectively as the drug carrier, whereby controlled release of drug. The electrosprayed particles morphology and size dictated the degradation of polymer matrix, therefore they influenced the release profile from drug loaded microparticles. The effects of electrospray processing parameters (flow rate, applied voltage and distance from the tip of needle to collector) on morphology and size of polycaprolactone (PCL) particles were investigated by scanning electron microscopy (SEM) and ImageJ software. In this research, the PCL solution was prepared by dissolving PCL in Dichloromethane at 4.5 % solution. In addition, processing parameters such as the flow rate (0.5 mL/h, 1 mL/h, 1.5 mL/h, 2 mL/h and 4 mL/h), the applied voltage (15 kV, 18 kV and 24 kV) and the collecting distance (15 cm, 20 cm, and 25 cm) were changed to examine the effects of them on size and morphology of PCL particles. The results indicated that at the suitable electrospraying parameters (18 kV, 1.5 mL/h, 20-25 cm), microparticles have obtained the uniform and stable morphology while at higher flow rate (2 mL/h and 4 mL/h), the particles were deformed and had bigger size.

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“…The resulting nanospherule is a spherical nanoparticle containing evenly scattered drug molecules in the polymeric matrix. 8,16 The electrospraying approach has been successfully used to produce polymeric nanoparticles for several drug classes, such as antibiotics, [17][18][19] anti-inflammatories, 20,21 and hormones, [22][23][24] among others. In this technique, a syringe is filled with a transparent solution of drug and other excipients such as polymeric components.…”

Section: Introductionmentioning

confidence: 99%

Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

Yousaf

Mustapha

Kim

et al. 2016

IJN

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Purpose The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate. Methods Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP) and Labrafil ® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion. Results All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1:4:0.5 resulted in a particle size of <200 nm with the drug present in the amorphous state. It demonstrated the highest solubility (32.51±2.41 μg/mL), an excellent dissolution (~85% in 10 minutes), and an oral bioavailability ~2.5-fold better than that of the free drug. It showed similar oral bioavailability compared to the conventional solid dispersion. Conclusion Electrosprayed nanospherules, which provide improved solubility and bioavailability, are promising drug delivery tools for oral administration of poorly water-soluble fenofibrate.

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Size mapping of electric field-assisted production of polycaprolactone particles

Cited by 51 publications

References 42 publications

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

Electrospray Method: Processing Parameters Influence on Morphology and Size of PCL Particles

Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

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