Size of microspheres passing through pulmonary circuit in the dog

Ring, G. C.; Blum, A; Kurbatov, T.; Moss, W. G.; Smith, Wade R.

doi:10.1152/ajplegacy.1961.200.6.1191

Cited by 55 publications

(16 citation statements)

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“…Ring et al [31] and Kaihara et al [17] demonstrated that the mi crocirculation of the lung almost completely trapped 15 ±5 (SD) mi crospheres injected into a peripheral vein. Ohlsson et al [23,25,26] demonstrated that also the microcirculation of the liver in dogs will trap almost all 15 ±5 (SD) ¿on spheres injected into the portal vein and the hepatic artery.…”

Section: Discussionmentioning

confidence: 99%

Regional Blood Flow Studies with Labelled Microspheres of Different Sizes in Dogs with and without Occlusion of the Common Bile Duct

Ohlsson¹

1971

Eur Surg Res

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Arteriovenous shunting in visceral organs was studied by simultaneous injection of 15 ± 5 and 50 ± 10 (SD) µm microspheres labelled with different isotopes into the left atrium of unanesthetized, unsedated dogs, pentobarbital anesthetized dogs, unanesthetized and unsedated dogs as well as anesthetized dogs subjected to a 1-week’s biliary stasis, and anesthetized dogs subjected to a 6-weeks’ biliary stasis. All dogs showed moderate shunting of the smaller spheres in the stomach. Dogs subjected to a 1-week’s biliary stasis demonstrated signs of shunting also in the jejunum-ileum. All anesthetized dogs, both with and without biliary obstruction, showed signs of substantial shunting outside the visceral area. In dogs subjected to a 1-week’s biliary stasis the liver blood flow was increased owing to increased flow through the hepatic artery.

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Section: Discussionmentioning

confidence: 99%

Regional Blood Flow Studies with Labelled Microspheres of Different Sizes in Dogs with and without Occlusion of the Common Bile Duct

Ohlsson¹

1971

Eur Surg Res

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“…In the animal experiments, droplets whose diameter was the same or less than the pulmonary capillaries would have passed through the pulmonary vascular bed by the time the animal was killed. Large droplets that passed through arteriovenous anastomosis would not be counted, too, but evidence has been presented that this is of little consequence during the first circulation (11). In the final analysis, the true size of vessels occluded by the droplets might be smaller than the measured droplet diameters, and hence the latter should be considered an approximation only.…”

Section: Discussionmentioning

confidence: 99%

Size of Gas Exchange Vessels in the Lung *

Sackner¹,

Feisal²,

Karsch³

1964

J. Clin. Invest.

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The provocative experiments of Staub (1) on the color of blood in arterioles of rapidly frozen lungs prompted us to investigate the quantitative aspects of gas exchange in vessels larger than capillaries in a living animal. His study raised the question of whether the amount of precapillary gas exchange is sufficient to invalidate the physiologic measurement of a) intrapulmonary right to left shunt while breathing oxygen (2), b) pulsatility of pulmonary capillary blood flow (3), and c) pulmonary arterial blood volume (4). We shall show both by measurements utilizing the ether plethysmographic method (4, 5) in a living dog and by calculations of the diffusing capacity of the pulmonary arterial system in a mathematical model that precapillary gas exchange is insufficient to invalidate the aforementioned techniques. MethodsTheory. The injection of ether dissolved in alcohol into the pulmonary artery of an apneic dog enclosed within a body plethysmograph produces a rise in plethysmographic pressure. This is due to the dissolved ether in the blood becoming gaseous in the alveoli and signals the arrival of ether at the site where the major portion of gas exchange takes place. If ether is dissolved in Lipomul,' a fine emulsion of cottonseed oil in water, ether evolution in the lungs is not delayed because the particles of the emulsion are so small that they pass through the pulmonary capillaries (4). However, if ether is dissolved in kerosene, the rate of ether gas evolution from the kerosene is retarded, presumably because kerosene lodges in a pulmonary vessel that limits the diffusion of ether (5). The rapid injection of one liquid into another liquid with which it is immiscible produces droplets whose size is related to the velocity of injection and the kinematic viscosities of the liquids (6). The size of the kerosene droplets containing the ether can be estimated micro-

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“…After injection of glass microspheres into the dog pulmonary artery, approximately 50 percent of spheres 2.8 -4.0 ~m in diameter could be found in the systemic circuit during the first circulation, but only 6 percent of those spheres eight ~m or larger got through the pulmonary circuit when compared with simultaneously injected tagged erythrocytes (83).…”

Section: The Lumentioning

confidence: 95%

Kinetics of reversible-sequestration of leukocytes by the isolated perfused rat lung

Goliaei¹

1980

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The kinetics and morphology of seauestration and margination of rat leukocytes were studied using an isolated perfused and ventilated rat lunq preparation. Whole rat blood, bone marrow suspension, or suspensions of peritoneal neutrophils, referred to as 1eukocyte suspensions, were used to perfuse the isolated rat lung either in the single-pass or continuous-circulation mode. Samples were collected from the lung affluent and effluent suspensions at various intervals and their leukocyte concentrations were determined. The lung was also oerfused with latex particle suspensions and the passage of particles thrOIJg~ the lung capillaries was studied. Lungs prefused with leukocvte or latex particle suspensions were fixed by the tracheal infusion techniaue, ethanol-cryofractured, and processed for scanning electron microscopy.When a leukocyte suspension was perfused through the lung in the single-pass mode, the rate of seauestration decreased as more cells were perfused. In contrast, latex particles of a size comparable to that of leukocytes were totally stopped by the lung. With the scanning electron microscope, latex particles were seen plugging the capillaries and small arterioles. When the leukocyte suspension was recirculated through the lung, cells were rapidly removed from circulation until a st~ady state was reached, after which no net removal of cells by the * Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720.

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Size of microspheres passing through pulmonary circuit in the dog

Cited by 55 publications

References 0 publications

Regional Blood Flow Studies with Labelled Microspheres of Different Sizes in Dogs with and without Occlusion of the Common Bile Duct

Regional Blood Flow Studies with Labelled Microspheres of Different Sizes in Dogs with and without Occlusion of the Common Bile Duct

Size of Gas Exchange Vessels in the Lung *

Kinetics of reversible-sequestration of leukocytes by the isolated perfused rat lung

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