Size Selective Ligand Tug of War Strategy to Separate Rare Earth Elements

Johnson, Katie N.; Driscoll, Darren M.; Damron, Joshua T.; Ivanov, Alexander S.; Jansone‐Popova, Santa

doi:10.1021/jacsau.2c00671

“…Furthermore, when Phen-2DIBA was titrated with La(NO 3 ) 3 under the same conditions, only ostensibly upfield-shifted broad peaks were detected (Figure e and Figures S18 and S19). Typically, broad peaks in NMR spectra indicated multiple species coexisted in the solution and no well-defined species formed . La(III) and Lu(III) ions only differed in their atomic radius in the current case; the NMR titration results thus could be indirect evidence for the superior ion selectivity of Phen-2DIBA .…”

Section: Resultsmentioning

confidence: 66%

A Simple yet Efficient Hydrophilic Phenanthroline-Based Ligand for Selective Am(III) Separation under High Acidity

Tian

¹

,

Liu

²

,

Kang

³

et al. 2023

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Highly selective hydrophilic ligands were believed to be an efficient way to overcome the massive amount of hazardous organic solvent used in the liquid−liquid extraction process and stood as a new frontier in the Lns(III)/Ans(III) partition. Current reported hydrophilic ligands suffer from harsh preparation conditions, inferior extraction performances, limited available chemical structures, and inability to carry out extraction under high acidity. In this article, we report a simple yet efficient carboxylic group modified phenanthroline-diimide ligand which displayed unexpected Lns(III)/Ans(III) and Ans(III)/Ans(III) separation capabilities in 1.5 M HNO 3 . Unique dimeric architectures for Eu(III) complexes were observed, which could be the origin of the outperforming selectivity and acid resistance. We believe this crystal engineering approach could inspire a renaissance in searching for new functional groups and coordination modes for efficient, highacid-tolerance Lns(III)/Ans(III) separation ligands.

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“…For a drug candidate, its stability, solubility, and permeability are determined by the ligand hydrolysis [169]. Their hydrolytic properties are determined by first degrading to either lipophilic or hydrophilic ligands with lipids or water [170]. After MBD is hydrolyzed, the metal compound and drug are released.…”

Section: Figure 3 Hydrolysis and Autophagy Degradation Mechanisms Of ...mentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

show abstract

“…For a drug candidate, its stability, solubility, and permeability are determined by the ligand hydrolysis [ 170 ]. Their hydrolytic properties are determined by first degrading to either lipophilic or hydrophilic ligands with lipids or water [ 171 ]. After MBD is hydrolyzed, the metal compound and drug are released.…”

Section: Ligand Degradation Properties In Anti-chemoresistancementioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

17

0

View full text Add to dashboard Cite

Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

show abstract

Size Selective Ligand Tug of War Strategy to Separate Rare Earth Elements

Cited by 32 publications

References 69 publications

A Simple yet Efficient Hydrophilic Phenanthroline-Based Ligand for Selective Am(III) Separation under High Acidity

A Simple yet Efficient Hydrophilic Phenanthroline-Based Ligand for Selective Am(III) Separation under High Acidity

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

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