Size-Tuning Ionization To Optimize Gold Nanoparticles for Simultaneous Enhanced CT Imaging and Radiotherapy

Dou, Yan; Guo, Yukun; Li, Xiaodong; Li, Xue; Wang, Sheng; Wang, Lin; Lv, Guoxian; Zhang, Xuening; Wang, Hanjie; Gong, Xiaoqun; Chang, Jin

doi:10.1021/acsnano.5b07473

Cited by 254 publications

(181 citation statements)

References 51 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…151 Some published results indicated that great difference existed even with the same concentration of AuNPs with different size. 152 In 2016, Dou et al 153 explored and confirmed the distinctive size-dependent effects based on a series of spherical AuNPs for enhanced CT imaging and radiotherapy ( Figure 9). 153 The result indicated that AuNPs had great size-dependent enhancement on CT imaging and radiotherapy (RT) in the size range of 3-50nm.…”

Section: Aunms Based Imagingmentioning

confidence: 94%

“…152 In 2016, Dou et al 153 explored and confirmed the distinctive size-dependent effects based on a series of spherical AuNPs for enhanced CT imaging and radiotherapy ( Figure 9). 153 The result indicated that AuNPs had great size-dependent enhancement on CT imaging and radiotherapy (RT) in the size range of 3-50nm. Interestingly, AuNPs with asize of ∼13nm could simultaneously possess superior CT contrast ability and significant radioactive disruption.…”

Section: Aunms Based Imagingmentioning

confidence: 94%

See 1 more Smart Citation

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

View full text Add to dashboard Cite

The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, sufficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most significant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral flow immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, fluorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

show abstract

Section: Aunms Based Imagingmentioning

confidence: 94%

Section: Aunms Based Imagingmentioning

confidence: 94%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

View full text Add to dashboard Cite

show abstract

“…Preoperative evaluation includes the condition of the whole body/organ and tumor (e.g., the shape, size, location, adjacent structures, tumor invasiveness, etc.). Gold NMs are proper candidates because of their high atomic number with a high attenuation coefficient and nontoxicity; [202][203][204][205] they can also reduce the dosage of contrast agents. However, with the advent of precision surgery era, intraoperative imaging technologies such as CAS cannot satisfy the need of accuracy, because of their limitations in detecting MRDs and real-time IGS.…”

Section: Preoperative Imaging For Precision Surgerymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

View full text Add to dashboard Cite

Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

show abstract

“…GNPs of 13 nm diameter were synthesized according to a previous report. 21 Initially, 150 mL of 2.2 mM Na 3 Ct$2H 2 O in deionized water was heated to 102 C.…”

Section: Synthesis Of Gnps-peg@cngrmentioning

confidence: 99%

Tumor angiogenesis targeting and imaging using gold nanoparticle probe with directly conjugated cyclic NGR

Zhang

et al. 2018

RSC Adv.

Self Cite

View full text Add to dashboard Cite

Angiogenesis is a vital process for the growth and metastasis of malignant tumor. Visualization of tumor angiogenesis is thus of great importance in the evaluation of biologic aggressiveness as well as monitoring of the response to anti-angiogenic therapy. Herein, we developed a probe based on gold nanoparticles (GNPs) directly surface-functionalized with a tumor-homing cyclized asparagine-glycinearginine peptide (SH-cNGR) and carboxylpoly(ethylene glycol)thiol (SH-PEG-COOH) via Au-S bonds.The obtained GNPs-PEG@cNGR probe was used to target the aminopeptidase-N (APN/CD13), which overexpressed in the endothelium of tumor angiogenesis. The CD13 binding affinities of the peptides were assessed by a receptor binding assay based on HUVEC and HepG2 cell (e.g. fluorescence imaging and X-ray computed tomography (CT)). The tumor targeting efficacy and the distribution of the GNPsPEG@cNGR in vivo were further evaluated in a subcutaneous 4T1 xenograft model by CT imaging and immunohistochemistry study. These results showed that the GNPs-PEG@cNGR rapidly and specifically bound to the tumor vasculature after intravenous injection. Quantitative studies demonstrated that GNPs-PEG@cNGR showed significantly higher and faster tumor uptake after intravenous injection compared to unlabeled GNPs-PEG. Moreover, the distribution of tumor enhancement was consistent with the spatial distribution of angiogenic blood. These results suggest that the designed GNPsPEG@cNGR probe may serve, in principle, as a promising CT contrast agent for targeted angiogenesis imaging and quantitative analysis.

show abstract

Size-Tuning Ionization To Optimize Gold Nanoparticles for Simultaneous Enhanced CT Imaging and Radiotherapy

Cited by 254 publications

References 51 publications

Applications of gold nanoparticles in medicine and therapy

Applications of gold nanoparticles in medicine and therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Tumor angiogenesis targeting and imaging using gold nanoparticle probe with directly conjugated cyclic NGR

Contact Info

Product

Resources

About