Sj&amp;ouml;gren&amp;rsquo;s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36  questionnaire and a meta-analysis

Zhang, Qiuxiang; Wang, Xulin; Chen, Haoyang; Shen, Biyu

doi:10.2147/ppa.s132751

Cited by 23 publications

(19 citation statements)

References 30 publications

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“…The non-SS group had the lowest scores in all eight dimensions of the SF-36. Several earlier studies have previously demonstrated that patients with pSS have lower GHRQoL than healthy controls [55][56][57][58] . There are studies that have investigated QoL in patients with other systemic disorders such as rheumatoid arthritis (RA) 36 and systemic lupus erythematosus 59,60 .…”

Section: General Health-related Quality Of Life Patients With Medicamentioning

confidence: 98%

Patients with non-Sjögren’s sicca report poorer general and oral health-related quality of life than patients with Sjögren’s syndrome: a cross-sectional study

Tashbayev

Garen

Palm

et al. 2020

Sci Rep

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Understanding the impact of the disease on quality of life is crucial in patient management. in this cross-sectional study, general and oral health-related quality of life questionnaires, and thorough examinations of oral and ocular dryness were performed in age-and sex-matched patients with primary Sjögren's syndrome (pSS group), non-Sjögren's syndrome sicca (non-SS group) and healthy controls. General and oral health-related quality of life were investigated with the 36-Item Short Form Health Survey and the 14-Item Oral Health Impact Profile questionnaires, respectively. Subjective symptoms of xerostomia and ocular dryness were recorded using the Summated Xerostomia inventory and ocular Surface Disease index, respectively. clinical examinations included evaluation of clinical oral dryness scores, candida counts, unstimulated and stimulated saliva secretory rates, tear osmolarity, tear film break-up time, Schirmer I test and ocular surface staining. Both patient groups had pronounced signs and symptoms of xerostomia and ocular dryness. even though the non-SS patients had less severe clinical signs than the pSS patients, they demonstrated much poorer general and oral health-related quality of life. in conclusion, non-SS patients require more attention in order to improve their quality of life. Sjögren's syndrome (SS) is a systemic, autoimmune connective tissue disease presenting a wide range of sicca symptoms, mainly dry mouth and dry eyes that result from permanently impaired salivary and lacrimal gland function 1. Sjögren's syndrome is also associated with extraglandular renal, pulmonary, and neurological manifestations in about 30% of patients 2. Around 5% of patients may develop lymphoma which is the most severe complication 2,3. Sjögren's syndrome is defined as primary SS (pSS) when occurring in the absence of an underlying rheumatic disorder, and as secondary SS (sSS) when associated with another connective tissue disorder 4,5. The large and diverse group of patients that have sicca symptoms consists of patients with various disorders who receive medical treatments that cause hypofunction of salivary and/or lacrimal glands. However, some patients have sicca symptoms in the absence of known diseases or medication, but without the distinctive features of pSS, namely Ro/SSA and/or La/SSB autoantibodies and lymphocyte infiltration in their minor salivary glands 6. In the present paper, this diverse group of patients was named the non-SS group, in order to highlight the fact that although they present with SS-like symptomatology they do not fulfil the diagnostic criteria for SS 7-20. The oral manifestations of SS can include subjective symptoms of dry mouth (xerostomia), burning sensation on the tongue, reduced sense of taste, and difficulties in swallowing food 21. Clinical findings of dry mouth include dry and fissured tongue, lack of saliva pool and bubbly saliva, tooth decay, and candidiasis 22. The subjective symptoms of dry eyes in SS can manifest as reduced vision, ocular discomfort, scratchiness, and pai...

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Section: General Health-related Quality Of Life Patients With Medicamentioning

confidence: 98%

Patients with non-Sjögren’s sicca report poorer general and oral health-related quality of life than patients with Sjögren’s syndrome: a cross-sectional study

Tashbayev

Garen

Palm

et al. 2020

Sci Rep

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“…Sjögren's syndrome (SS) is a chronic autoimmune disease in which the exocrine glands are the main tissue damaged, especially salivary and lacrimal glands. As one of most common autoimmune diseases, SS affects 0.5% to 1.0% of the population and is most commonly observed in women in the fifth decade of life . SS can present as primary Sjögren's syndrome (pSS) or secondary Sjögren's syndrome (sSS) according to whether the patient has another autoimmune disease .…”

Section: Introductionmentioning

confidence: 99%

“…As one of most common autoimmune diseases, SS affects 0.5% to 1.0% of the population and is most commonly observed in women in the fifth decade of life. 1 SS can present as primary Sj€ ogren's syndrome (pSS) or secondary Sj€ ogren's syndrome (sSS) according to whether the patient has another autoimmune disease. 2 Clinically, dryness is the overwhelming complaint, although other general features (fatigue and chronic pain) and extraglandular manifestations (including lymphoma) are also involved.…”

Section: Introductionmentioning

confidence: 99%

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

et al. 2018

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The aberrant expression of interleukin-17 (IL-17) has been reported in primary Sjögren's syndrome (pSS). Abnormalities in IL-17 can promote the production of pro-inflammatory cytokines and aggravate autoimmune disorders. The aim of this study was to investigate alterations of IL-17 in patients with pSS and explore the correlation between IL-17 and disease severity. Eight databases were searched for original studies reporting the expression of IL-17 in patients with pSS and controls. Eligible reports were included in the pooled analysis, and subgroup evaluations were performed according to different types of controls and IL-17 measurement methods. Newcastle-Ottawa Scale criteria were used to assess the risk of bias of the included studies. In total, 45 articles are included in the meta-analysis. The expression of IL-17 is significantly increased in patients with pSS compared to controls. Furthermore, patients with pSS without immunosuppressive treatment show markedly higher IL-17 levels. In addition, patients with pSS with positive rheumatoid factors tend to express a higher level of IL-17 than patients with negative rheumatoid factors. Negative correlations between IL-17 levels and ocular parameters are also found in patients with pSS. The results are similar after adjustment by "trim and fill" methods. In conclusion, the expression of IL-17 is obviously increased in patients with pSS, especially among those without immunosuppressive treatment. In addition, IL-17 level correlates with the disease severity of pSS. These findings demonstrate the significance of IL-17 overexpression in patients with pSS and may provide insights for the development of therapeutic interventions targeting IL-17 for pSS.

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“…It affects predominantly the female sex and is characterized by lymphocytic infiltration of exocrine glands and other organs, resulting in dry eye and dry mouth and extraglandular systemic findings, such as pain, myalgia or polyarthralgia, among others [ 1 ]. The condition has a marked negative impact on health-related quality of life and social functioning [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with severe dry eye in primary Sjögren’s syndrome diagnosed patients

et al. 2018

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IntroductionPrimary Sjögren’s syndrome (pSS) is an autoimmune disease, characterized by lymphocytic infiltration of exocrine glands and other organs, resulting in dry eye, dry mouth and extraglandular systemic findings.ObjectiveTo explore the association of severe or very severe dry eye with extraocular involvement in patients diagnosed with primary Sjögren’s syndrome.MethodsSJOGRENSER registry is a multicenter cross-sectional study of pSS patients. For the construction of our main variable, severe/very severe dry eye, we used those variables that represented a degree 3–4 of severity according to the 2007 Dry Eye Workshop classification. First, bivariate logistic regression models were used to identify the effect of each independent variable on severe/very severe dry eye. Secondly, multivariate analysis using regression model was used to establish the independent effect of patient characteristics.ResultsFour hundred and thirty-seven patients were included in SJOGRENSER registry; 94% of the patients complained of dry eye and 16% developed corneal ulcer. Schirmer’s test was pathological in 92% of the patients; 378 patients presented severe/very severe dry eye. Inflammatory articular involvement was significantly more frequent in patients with severe/very severe dry eye than in those without severe/very severe dry eye (82.5 vs 69.5%, p = 0,028). Inflammatory joint involvement was associated with severe/very severe dry eye in the multivariate analysis, OR 2.079 (95% CI 1.096–3.941).ConclusionSevere or very severe dry eye is associated with the presence of inflammatory joint involvement in patients with pSS. These results suggest that a directed anamnesis including systemic comorbidities, such as the presence of inflammatory joint involvement or dry mouth in patients with dry eye, would be useful to suspect a pSS.

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Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Cited by 23 publications

References 30 publications

Patients with non-Sjögren’s sicca report poorer general and oral health-related quality of life than patients with Sjögren’s syndrome: a cross-sectional study

Patients with non-Sjögren’s sicca report poorer general and oral health-related quality of life than patients with Sjögren’s syndrome: a cross-sectional study

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

Factors associated with severe dry eye in primary Sjögren’s syndrome diagnosed patients

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