Sjogren’s Syndrome Can Appear at Any Age

Abstract

Sjögren's syndrome is diagnosed on the basis of specific changes in the eyes, mouth, and salivary glands, along with the finding of autoantibodies and histological changes. Sjögren's syndrome usually affects the eyes and mouth. Dry eyes are irritated and sensitive to light, the cornea is eroded in more severe cases, and bits of epithelium hang from its surface, resulting in impaired vision. Decreased salivation makes chewing and swallowing difficult and favors secondary candidiasis, loose teeth, and the formation of stones in the salivary ducts. Weak sense of taste and smell. Drying damages the skin and mucous membranes of the nose, pharynx, larynx, trachea, and vagina. Cough and respiratory infections occur, sometimes alopecia. In 1/3 of patients, the parotid glands are enlarged, usually harder, smooth, and slightly sensitive.A promising field of research is the cap potential healing function of mesenchymal stem cells (MSC) inside the remedy of primary Sjögren's syndrome. To date, proof has been collected that transfusion of MSCs can suppress autoimmunity and repair salivary gland secretory features in each mouse model and in sufferers with primary Sjögren's syndrome. This impact is mediated with the aid of inducing regulatory T cells, suppressing Th1, Th17, and T follicular helper cell responses.The prognosis of Sjögren's syndrome is easy, while the medical presentation is florid and can then be primarily based totally on records and the outcomes of bodily exams alone. However, several investigations are required in maximum sufferers with suspected Sjögren's syndrome, in whom there are only some early signs. Many investigations are possible; however, most effective, the minimal required to make the prognosis wishes to be performed. A choice is commonly important due to the fact each look might be negative in a small percentage of sufferers, and none is absolutely unique.