Sjogren's Syndrome in a Celiac Patient: Searching for Environmental Triggers

D’Onofrio, Ferruccio; Miele, Luca; Diaco, M; Santoro, Luca; Socio, G. De; Montalto, Massimo; Grieco, Antonio; Gasbarrini, Giovanni; Manna, Raffaele

doi:10.1177/039463200601900222

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Thrombocytopenia has rarely been reported in CD, and may be autoimmune in nature [30]. Siögren's disease has been reported in CD, and its appearance in CD is probably related to environmental factors as triggers or precipitators [31]. Also a case of severe non-alcoholic steato-hepatitis (NASH) was observed.…”

Section: Discussionmentioning

confidence: 99%

Complications in Celiac Disease Under Gluten-Free Diet

et al. 2008

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We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD at the time of the diagnosis. The mean time under GFD was 7.13 years (range 1-15 years). Out of 549 patients, 381 (69.4%) were fully compliant, 112/549 (20.4%) reported less than one dietary transgression/month, and 56/549 (10.2%) reported at least one dietary transgression/month. Out of 549 patients, 18 (3.3%) patients developed complications under GFD (seven malignant and 11 nonmalignant complications). Fourteen patients were previously affected by classical CD (5.6% of the overall patients with classical CD), and four were affected by subclinical CD (1.5% of the overall patients with subclinical CD). None of the patients affected by silent CD developed complications. There was no statistical difference between the mean age of the two groups developing complications (P = n.s.). Complications appeared after a mean time under GFD of 6.5 years in classical CD, and after a mean time of 3.5 years in subclinical CD (P = n.s.). Finally, 6/14 (42.8%) patients with classical CD were not fully compliant to GFD, while 2/4 (50%) of subclinical CD patients were not fully compliant to GFD (P = n.s.). Less than 5% of CD patients may develop complications under GFD. Complications seem to affect more classical CD than subclinical CD, and seem to be irrespective of optimal GFD adherence.

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Section: Discussionmentioning

confidence: 99%

Complications in Celiac Disease Under Gluten-Free Diet

et al. 2008

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“…The association between CD and SS-related autoantibodies might be based on common genetic background of these two pathologies, related to DR3-DQ2 heterodimer coded by the DQA1*0501 and DQB1*0201 alleles[ 36 , 37 ]. Patients possessing these genetic markers had extractable nuclear antigen antibodies, and especially SS-B/La antibodies more frequent than patients negative for these alleles[ 38 ]. Moreover, it is well recognized that CD is associated with specific HLA types in virtually all populations that have been tested, and this very high negative predictive value of HLA-DQ2/DQ8 genotyping can be used to effectively rule out the disease in selected clinical situations[ 22 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Celiac disease and Sjögren’s syndrome: A case report and review of literature

Balaban¹,

Mihai²,

Dima³

et al. 2020

WJCC

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BACKGROUND Celiac disease (CD) is a systemic, chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals, with a prevalence of 1% worldwide. Sjogren's syndrome (SS) is also a systemic autoimmune disease, mainly characterized by ocular and oral sicca symptoms and signs. Sharing a common genetic background, CD and SS are known associated autoimmune diseases, but currently available guidelines are not reporting it. CASE SUMMARY We report the case of a 39-year-old woman, who was in the care of her rheumatologist for 2 years with SS. On routine follow-up she was found to have iron deficiency, without anemia. She had no gastrointestinal complaints and denied any obvious source of blood loss. IgA tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy. A diagnosis of CD was set and gluten-free diet was recommended. CONCLUSION We present a review of existing data in the literature regarding the association of the two diseases, summarizing prevalence studies of CD in SS patients and the other way around. Screening recommendations and future research perspectives are also discussed, highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

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“…Adenoidal hypertrophy which obstructs the nasal airway in children is associated with numerous symptoms, including: snoring, nasal obstruction, oral breathing, rhinolalia, restsleep, hypersomnolence, and enuresis (2)(3)(23)(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Hypertonic Saline Solution in Children with Adenoidal Hyperytrophy: Preliminary Evidence

Ciprandi

Varricchio

Capasso³

et al. 2007

Eur J Inflamm

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Adenoidal hypertrophy (AH) is a frequent problem in children. A preliminary study evidenced that intranasal hypertonic solutions may exert an anti-inflammatory activity. The aim of the study is to evaluate the effect of intranasal hypertonic or isotonic solutions in children affected with AH. For this purpose, 78 children with AH were evaluated in a randomised and controlled study. Inclusion criteria for the study required that each patient had to have a III or IV degree of AH on the initial endoscopic examination. Children were treated with intranasal hypertonic or isotonic saline solution for 8 weeks. After treatment, endoscopy was performed to evaluate AH degree. Hypertonic treatment was associated with significant (p

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Sjogren's Syndrome in a Celiac Patient: Searching for Environmental Triggers

Cited by 9 publications

References 23 publications

Complications in Celiac Disease Under Gluten-Free Diet

Complications in Celiac Disease Under Gluten-Free Diet

Celiac disease and Sjögren’s syndrome: A case report and review of literature

Hypertonic Saline Solution in Children with Adenoidal Hyperytrophy: Preliminary Evidence

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