2003
DOI: 10.1152/ajpcell.00250.2002
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SK4/IK1-like channels mediate TEA-insensitive, Ca2+-activated K+ currents in bovine parotid acinar cells

Abstract: Takahata, T., M. Hayashi, and T. Ishikawa. SK4/IK1-like channels mediate TEA-insensitive, Ca 2ϩ -activated K ϩ currents in bovine parotid acinar cells.

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Cited by 38 publications
(40 citation statements)
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“…Some SK Ca channels, e.g. SK4 and SK ap-ins (apamin-insensitive), share pharmacological characteristics with IK Ca channels [13,32,35], which might reflect the high degree of structural homology between SK4 and mIK1 [37]. However, the I/V curves of apamin-insensitive, ChTX-sensitive SK4 channels differ from those of IK Ca channels, in that the SK4 I/V are linear at potentials positive to 50 mV [13,32].…”
Section: Discussionmentioning
confidence: 99%
“…Some SK Ca channels, e.g. SK4 and SK ap-ins (apamin-insensitive), share pharmacological characteristics with IK Ca channels [13,32,35], which might reflect the high degree of structural homology between SK4 and mIK1 [37]. However, the I/V curves of apamin-insensitive, ChTX-sensitive SK4 channels differ from those of IK Ca channels, in that the SK4 I/V are linear at potentials positive to 50 mV [13,32].…”
Section: Discussionmentioning
confidence: 99%
“…1). KCNN4 is expressed abundantly in epithelial cells of colon [107] and of salivary glands [75,95] and less in small intestine [34,41]. However, during cAMPmediated intestinal Cl secretion, KCNN4 activity is very low due to a reduction of intracellular Ca 2+ .…”
Section: Basolateral Epithelial K + Channels: Driving Force and Cell mentioning
confidence: 99%
“…Both exocrine and other fluid-secreting epithelia often express K ϩ channels whose activity can facilitate Cl Ϫ efflux by maintaining a hyperpolarized membrane voltage. Rodent (and other) salivary glands express two types of Ca 2ϩ -activated potassium channels, a BK channel and an IK channel (17)(18)(19)(20)(21)(22). These BK and IK channels have biophysical and pharmacological properties consistent with those expected of channels encoded by the Slo (Kcnma1) and Kcnn4 genes, respectively (6,22).…”
mentioning
confidence: 96%
“…Rodent (and other) salivary glands express two types of Ca 2ϩ -activated potassium channels, a BK channel and an IK channel (17)(18)(19)(20)(21)(22). These BK and IK channels have biophysical and pharmacological properties consistent with those expected of channels encoded by the Slo (Kcnma1) and Kcnn4 genes, respectively (6,22). Both channels are activated by the increase in intracellular Ca 2ϩ produced by muscarinic agonists, but the evidence suggests that fluid secretion may be independent of BK channel activity (17,20,23), leaving IK channels to play this role.…”
mentioning
confidence: 99%