SKA3 Serves as a Biomarker for Poor Prognosis in Kidney Renal Papillary Cell Carcinoma

Feng, Dechao; Zhang, Facai; Liu, Ling; Xiong, Qiao; Xu, Hang; Wei, Wuran; Liu, Zhenghua; Yang, Lu

doi:10.2147/ijgm.s336799

Cited by 14 publications

(8 citation statements)

References 43 publications

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“…Compared with other renal cell carcinomas, there is a higher incidence of lymph node (LN) involvement, and LN staging is more important in pathological grading for the diagnosis of KIRP. [ 29 ] Interestingly, in our study, CCNB1 expression positively correlated with LN invasion. Furthermore, CCNB1 is significantly upregulated in patients with KIRP tumor stage and metastasis.…”

Section: Discussionmentioning

confidence: 45%

Bioinformatics analysis highlights CCNB1 as a potential prognostic biomarker and an anti-kidney renal papillary cell carcinoma drug target

Gong,

et al. 2024

Medicine

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Kidney renal papillary cell carcinoma (KIRP) is a common urinary tumor that causes lymph node invasion. Once metastatic, the prognosis is poor and there is a lack of effective early diagnostic markers for this tumor. The expression of CCNB1 in KIRP tumor tissues was significantly higher than that in normal tissues in The Cancer Genome Atlas database with or without the genotype-tissue expression database, and a consistent result was obtained in 32 paired tissues. In addition, CCNB1 expression increased remarkably with the progression of the T and M stages. Moreover, using the online HPA database, we verified that the immunohistochemical scores of CCNB1 in KIRP were higher than those in the normal kidney tissues. The higher expression group of CCNB1 showed a worse prognosis in KIRP. Moreover, the receiver operating characteristic curve, univariate and multivariate analyses, and construction of the column diagram further illustrated that CCNB1 was an independent prognostic factor for KIRP. Meanwhile, CCNB1 could better predict the 1- and 3-year survival rates of KIRP. Six genes were significantly and positively co-expressed with CCNB1. We also found that the CCNB1 high-expression group was enriched in the ECM_RECEPTOR_INTERACTION and FOCAL_ADHESION pathways. Finally, drug sensitivity analysis combined with molecular docking identified 5 targeting drugs with the strongest binding activity to CCNB1. CCNB1 is a potential and reliable biomarker for KIRP diagnosis and can be used to predict the survival of patients with KIRP. The 5 selected drugs targeting CCNB1 may provide new hopes for patients with KIRP metastasis.

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Section: Discussionmentioning

confidence: 45%

Bioinformatics analysis highlights CCNB1 as a potential prognostic biomarker and an anti-kidney renal papillary cell carcinoma drug target

Gong,

et al. 2024

Medicine

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“…Current researches about SKA3 and urinary cancers are rudimentary, mainly based on bioinformatic analysis and in vitro functional experiments. Evidence from the bioinformatic analysis indicated that SKA3 expression was higher in adrenocortical carcinoma 25 and kidney renal papillary cell carcinoma and was associated with poor survival 3 . In terms of prostate cancer, we previously found that SKA3 was highly expressed in tumor tissues and its knockdown could significantly inhibited the proliferation of various cell lines, including LNCap, C4-2, C4-2B, PC3, and DU145 2 .…”

Section: Role Of Ska3 In Human Cancermentioning

confidence: 99%

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

Feng,

Wang,

Xiao

et al. 2024

International Journal of Surgery

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Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, we comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis and narrative summary. We also provided top 10 predicted drugs targeting SKA3. We proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.

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“… 3 pRCC occurs sporadically, with several agents including mTOR inhibitors could be used in the treatment of advanced and metastatic pRCC. 4 ChRCCs originated from the intercalated cell of distal tubules, tumor protein P53 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) were the two main frequently mutated genes. 5 CcRCC was the main pathological types, and associated with von Hippel-Lindau (VHL) disease.…”

Section: Introductionmentioning

confidence: 99%

High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

Wang¹,

Wei-quan²,

Lou³

et al. 2023

PGPM

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Background Invasion and metastasis led to poor prognosis and death of clear cell renal cell carcinoma (ccRCC) patients. The deoxynucleotidyl transferase terminal interacting protein 1 (DNTTIP1) was reported to promote multiple tumor progression. However, there is no research about DNTTIP1 in ccRCC. Methods Kaplan–Meier survival analysis, multivariate analysis demonstrated the prognostic indicator in overall survival (OS) and disease-free survival (DFS) of ccRCC with DNTTIP1 expression in the Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC). Receiver operator characteristic (ROC) curve analyzed diagnostic ability of DNTTIP1 in TCGA-KIRC and validation dataset. The quantitative real-time polymerase chain reaction (qRT-PCR) detected the DNTTIP1 expression in renal cancer tissues, and the Office of Cancer Clinical Proteomics Research (CPTAC) verified the protein expression of DNTTIP1. Moreover, nomogram predicted the role of DNTTIP1 in ccRCC patient. Single-sample Gene Set Enrichment Analysis (SsGSEA) and GSEA evaluated the pathogenesis role of DNTTIP1 in TCGA-KIRC. Results DNTTIP1 expression was higher in ccRCC tumor tissues. High expression of DNTTIP1 was associated with poor OS (HR = 1.618, P < 0.0001), and poor DFS (HR = 1.789, P < 0.0001). SsGSEA and GSEA showed DNTTIP1 was associated with hypoxia, epithelial-mesenchymal transition (EMT), angiogenesis, G2M checkpoint. DNTTIP1 had a positive correlation with EMT biomarkers in ccRCC, and might be an effective target for ccRCC. Conclusion This study provided that higher expression of DNTTIP1 predicted poor prognosis in ccRCC, and DNTTIP1 might be a novel detection biomarker and therapeutic target of tumor malignant in the future.

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SKA3 Serves as a Biomarker for Poor Prognosis in Kidney Renal Papillary Cell Carcinoma

Cited by 14 publications

References 43 publications

Bioinformatics analysis highlights CCNB1 as a potential prognostic biomarker and an anti-kidney renal papillary cell carcinoma drug target

Bioinformatics analysis highlights CCNB1 as a potential prognostic biomarker and an anti-kidney renal papillary cell carcinoma drug target

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

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