SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force
Miquel Rosas-Salvans,
Caleb Rux,
Moumita Das
et al.
Abstract:The kinetochore links chromosomes to spindle microtubules to drive chromosome segregation at cell division. We recently uncovered that the kinetochore complex Astrin-SKAP, which binds microtubules, reduces rather than increases friction at the mammalian kinetochore-microtubule interface. How it does so is not known. Astrin-SKAP could affect how other kinetochore complexes bind microtubules, reducing their friction along microtubules, or it could itself bind microtubules with similar affinity but lower friction… Show more
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