Many metallic ore deposits of the Late Cretaceous to Early Tertiary periods are distributed in the Gyeongsang Basin. Previous and newly analyzed sulfur isotope data of 309 sulfide samples from 56 ore deposits were reviewed to discuss the genetic characteristics in relation to granitoid rocks. The metallogenic provinces of the Gyeongsang Basin are divided into the Au-Ag(-Cu-Pb-Zn) province in the western basin where the sedimentary rocks of the Shindong and Hayang groups are distributed, Pb-Zn(-Au-Ag-Cu), Cu-Pb-Zn(-Au-Ag), and Fe-W(-Mo) province in the central basin where the volcanic rocks of the Yucheon Group are dominant, and Cu(-Mo-W-Fe) province in the southeastern basin where both sedimentary rocks of the Hayang Group and Tertiary volcanic rocks are present. Average sulfur isotope compositions of the ore deposits show high tendencies ranging from 2.2 to 11.7‰ (average 5.4‰) in the Pb-Zn(-Au-Ag-Cu) province, −0.7 to 11.5‰ (average 4.6‰) in the Cu-Pb-Zn(-Au-Ag) province, and 3.7 to 11.4‰ (average 7.5‰) in the Fe-W(-Mo) province in relation to magnetite-series granitoids, whereas they are low in the Au-Ag(-Cu-Pb-Zn) province in relation to ilmenite-series granitoids, ranging from −2.9 to 5.7‰ (average 1.7‰). In the Cu(-Mo-W-Fe) province δ 34 S values are intermediate ranging from 0.3 to 7.7‰ (average 3.6‰) and locally high δ 34 S values are likely attributable to sulfur derived from the Tertiary volcanic rocks during hydrothermal alteration through faults commonly developed in this region. Magma originated by the partial melting of the 34 S-enriched oceanic plate intruded into the volcanic rocks and formed magnetite-series granitoids in the central basin, which contributed to high δ 34 S values of the metallic deposits. Conversely, ilmenite-series granitoids were formed by assimilation of sedimentary rocks rich in organic sulfur that influenced the low δ 34 S values of the deposits in the western and southeastern provinces.