Skeletal carcinomatosis in endometrial clear cell carcinoma at initial presentation: a case report

Abstract

Bone metastasis is frequently seen in different solid tissue malignancies. However, it is a very rare entity in endometrial cancers and most of the previous reports were localized to a single bone. To the best of our knowledge, this is the first report of a case with disseminated bone metastasis from endometrial clear cell carcinoma. A 69-year-old, multiparous woman presented with the complaint of postmenopausal bleeding. Diagnostic workup revealed endometrial clear cell carcinoma. After comprehensive surgical staging, the patient was found to be at FIGO stage IIIC. Three weeks after the operation, an intractable back pain developed. Direct graphics of the lumbosacral region were suspicious of metastasis, and further evaluation of the patient revealed metastasis in multiple bones including calvarium, thoracolumbal vertebrae, pelvic bones, costae, collum of the right femur, and trochanter major of the left femur. Bone metastasis in endometrial clear cell carcinoma may be seen at initial presentation and may involve multiple bones. Whole-body scanning with scintigraphic evaluation is a reasonable approach to evaluate the extension of the bone involvement. Further studies are needed to elucidate the true incidence and management of bone metastasis in endometrial clear cell carcinoma.

External hemipelvectomy as treatment for solitary coxofemoral metastasis from endometrial carcinoma: Case report and review of the literature

“…In cases of a single site of metastasis, local radiotherapy may be effective 27 and should be combined with surgery, such as for amputations described for calcaneal metastases. There seems to be evidence that radiotherapy improves the survival of these patients, while chemotherapy could be useful in patients with multiple bone metastases 31 …”

“…Palliative treatment with radiotherapy and chemotherapy is recommended, and has been related to the acceptable control of tumor size and pain 31 . This treatment mode is probably the best option in patients with several affected bones.…”

“…There seems to be evidence that radiotherapy improves the survival of these patients, while chemotherapy could be useful in patients with multiple bone metastases. 31 Palliative treatment with radiotherapy and chemotherapy is recommended, and has been related to the acceptable control of tumor size and pain. 31 This treatment mode is probably the best option in patients with several affected bones.…”

“…31 Palliative treatment with radiotherapy and chemotherapy is recommended, and has been related to the acceptable control of tumor size and pain. 31 This treatment mode is probably the best option in patients with several affected bones. Moreover, in cases of welldefined lesions or in those of clinical persistence, surgical resection could be indicated.…”

Tibial bone metastasis as an initial presentation of endometrial carcinoma diagnosed by fine-needle aspiration cytology: A case report and review of the literature

“…A further review of the literature revealed 38 articles[ 2 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 ] between 1967 and 2011, describing 61 patients with metastatic endometrial cancer to bone. Including our case, these patients ranged in age from 32 to 86 years, with an average age of 62 years (standard deviation 10.8 years) [ Figure 6 ].…”