Skeletal clues apparently distinguishing Waldenstrom's macroglobulinemia from multiple myeloma and leukemia

Abstract

This study was conducted to characterize macroscopically and by conventional radiography the bony lesions in a case of Waldenstrom's macroglobulinemia and to compare and contrast it with those of the other major hematologic lymphoproliferative disorders, multiple myeloma and leukemia. Two varieties of lytic skeletal lesions were found in Waldenstrom's macroglobulinemia. One was sharply defined, spheroid lesions with smooth borders and effaced/erased trabeculae. The second was in the form of coalescing pits (holes) with smooth, minimally remodeled edges. The appearance combined features of multiple myeloma and leukemia, but were mutually exclusive in those diseases. Spheroid lesions with effaced edges were absent in leukemia, while pits were absent in multiple myeloma. Fronts of resorption were not noted in Waldenstrom's macroglobulinemia. The combination of some of the features of leukemia and myeloma appear to allow recognition of Waldenstrom's macroglobulinemia.

Leukemia in Ancient Egypt: Earliest case and state‐of‐the‐art techniques for diagnosing generalized osteolytic lesions

“…Analyses that focus on differential diagnoses that include leukemia are scarce in the review of archaeological remains (Klaus, ; Rothschild et al, ; Rothschild, Ruhli, & Rothschild, ). Moreover, some of these articles relied on contemporary skeletal collections in which the cause of death was known (Rothschild et al, ; Rothschild et al, ).…”

“…Analyses that focus on differential diagnoses that include leukemia are scarce in the review of archaeological remains (Klaus, 2016;Rothschild et al, 1997;Rothschild, Ruhli, & Rothschild, 2002).…”

“…Moreover, some of these articles relied on contemporary skeletal collections in which the cause of death was known (Rothschild et al, 1997;Rothschild et al, 2002). Hyperparathyroism is a disease related with high levels of parathyroid hormone in blood.…”

Anterior Segment Ischemia and Retinochoroidal Vascular Occlusion After Intralesional Steroid Injection

“…Postmortem studies reported in the literature revealed bony changes including lytic lesions without bony resorption. 16 The left dyschromatopsia and afferent pupillary defect in this patient likely represent compressive optic neuropathy because of the intraorbital portion of the mass.…”

Abnormal bone remodelling and increased levels of macrophage inflammatory protein‐1 alpha (MIP‐1α) in Waldenström macroglobulinaemia

“…This malignancy is thought to originate from a B cell stimulated to differentiate to a plasma cell that has been exposed to the germinal centre environment. Lytic bone disease is very uncommon in WM (Rothschild et al, 2002). However, abnormal bone remodelling close to malignant cells, characterised by increased bone resorption and normal or reduced bone formation that leads to microresorption lesions, has been described in almost 80% of WM patients in bone histomorphometric studies (Marcelli et al, 1988).…”