Skeletal fluorosis mimicking seronegative arthritis

Gupta, Ramesh C.; Kumar, Antresh; Bandhu, Seema Dutt; Gupta, Shalabh

doi:10.1080/03009740600759845

Cited by 23 publications

(9 citation statements)

References 5 publications

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“…Specially in the regions of endemic fluorosis, numbering at least 22 countries 10 , loss of appetite, flatulence, constipation, intermittent diarrhoea mimicking irritable bowel syndrome 7, 11 , and even colitis 12 have also been described as consequences of fluorosis.…”

Section: Introductionmentioning

confidence: 99%

Enteric innervation combined with proteomics for the evaluation of the effects of chronic fluoride exposure on the duodenum of rats

Melo

Perles

Zanoni

et al. 2017

Sci Rep

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Ingested fluoride (F) is absorbed mainly in the small intestine, which is controlled by the Enteric Nervous System (ENS). Although important intestinal symptomatology has been described after excessive F exposure, there have been no studies reporting the effects of F on the ENS. In this study, the effects of chronic F exposure were evaluated on the duodenums of rats through proteomic and morphological analyses. Concentrations of 0, 10, or 50 ppm of F were applied to the drinking water for 30 days. Immunofluorescence techniques were performed in the myenteric plexus of the duodenum to detect HuC/D, neuronal nitric oxide (nNOS), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), and substance P (SP). The 50 ppm F group presented a significant decrease in the density of nNOS-IR neurons. Significant morphological alterations were also observed in HUC/D-IR and nNOS-IR neurons; VIP-IR, CGRP-IR, and SP-IR varicosities for both groups (10 and 50 ppm F). Proteomic analysis of the duodenum demonstrated alterations in the expression of several proteins, especially those related to important biological processes, such as protein polymerization, which helps to explain the downregulation of many proteins upon exposure to 50 ppm of F.

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Section: Introductionmentioning

confidence: 99%

Enteric innervation combined with proteomics for the evaluation of the effects of chronic fluoride exposure on the duodenum of rats

Melo

Perles

Zanoni

et al. 2017

Sci Rep

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“…1 This can easily be mistaken for other conditions such as rheumatoid arthritis, osteoarthritis or seronegative spondyloarthropathy. 2 Fluorosis is however known to be more prominent in the axial skeleton than the peripheral.…”

Section: Discussionmentioning

confidence: 99%

Skeletal fluorosis mimicking seronegative spondyloarthropathy: a deceptive presentation

et al. 2011

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“…Osteoarthritis, osteonecrosis, and fractures can occur as a result of the marked bony hardness. Some bone changes can imitate a seronegative arthritis 5 . Ligamentous hyperostosis occurs.…”

Section: Discussionmentioning

confidence: 99%