Skeletal Langerhans Cell Histiocytosis Presenting After Periodontal Disease and Diabetes Insipidus: A Case Report

Abstract

Langerhans Cell Histiocytosis (LCH) is a rare condition with extreme clinical variability in terms of presentation, progression and outcomes. A case is described in which Diabetes Insipidus (DI) and periodontal disease preceded the development of a lesion of the temporal bone. Central DI in the child or young adult should prompt an extracranial survey for possible LCH. Periodontal disease has a marked association with LCH, so when DI and periodontal disease co-exist, the index of suspicion for LCH should be raised.