Skeletal Limb Deficiencies

Freire‐Maia, N.; Azevedo, J.B.C.

doi:10.1016/s0140-6736(68)91782-0

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…The present investigation (made on the basis of a house-to-house survey) had the advantage of avoiding ascertainment biases which would increase recurrence, unlike our first investigations (Freire-Maia and Freire-Maia 1964and 1967, Fonseca and Freire-Maia 1970. Some of its main conclusions have already been briefly mentioned before (Freire-Maia and Azevedo 1968, Freire-Maia 1969.…”

Section: Introductionmentioning

confidence: 75%

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Reduction Deformities, Twinning and Mortality in Brazilian Whites and Negroes

Freire‐Maia

Azevedo

1977

Acta genet. med. gemellol.

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A series of house-to-house surveys in Central Brazil revealed 32 cases of reduction deformities of the limbs (brachydactyly, synbrachydactyly, ectrodactyly, amely, adactyly, achiry, apody, etc.) among 58,761 births (0.54 per thousand, being 0.66 per thousand among Whites and 0.43 per thousand among Mulattoes and Negroes). No sibship was found with two or more equally affected singleton members. One case of concordance among twins is referred. There were no parity, inbreeding, race and sex effects. Both hands and both feet were also equally affected. Precocious mortality and twinning were significantly higher among affected individuals. The presence of cleft lip and palate in one of our index patients may also reflect an etiological relationship. Among the sibs, the total incidence of congenital malformations was similar to that generally accepted for general populations.

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Section: Introductionmentioning

confidence: 75%

“…Reduction deformities of the limbs are a rather heterogeneous nosologic group both as regards clinical and etiological aspects (Freire-Maia 1969). In the large majority of them, etiology is totally unknown and the average recurrence risk is practically nil.…”

Section: Introductionmentioning

confidence: 99%