Skeletal maturity of the hand in an East African group from Sudan

Elamin, Fadil; Abdelazeem, Nihal; Elamin, Ahmed; Saif, Duaa; Liversidge, Helen M.

doi:10.1002/ajpa.23247

Cited by 12 publications

(6 citation statements)

References 45 publications

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“…Our data are in agreement with the findings of a previous study [22], which reported that nonobese children and adolescents who were shorter (lower height Z-score) had more delayed BA. In addition, in one large cross-sectional study with 665 males and 1018 females aged 3-25 years conducted in North Sudan, investigators reported that skeletal maturity was relatively more delayed in the low height group [23]. This suggests that we should pay more attention to BA delay in short children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Association between Insulin‐Like Growth Factor‐1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

Zhao

Zhang

Chu

et al. 2020

BioMed Research International

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Objective. Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods. In this retrospective cohort study, we observed 783 short children and adolescents, 229 of whom received GH therapy. Skeletal maturation was assessed based on the difference between bone age (BA) and chronological age (CA) (noted as BA-CA). Anthropometric data and laboratory values were measured, and BA was evaluated using the Greulich and Pyle method. Results. The delayed BA group was defined as BA‐CA<−2 SD (n=457), and the occurrence rate of BA delay was 58.37%. A nonlinear relationship was observed between the IGF-1 standard deviation score (IGF-1 SDS) and BA-CA before and after GH therapy. Before GH therapy, there was a significant positive association between the IGF-1 SDS and BA-CA when the IGF-1 level was greater than -2 SDS (β 0.17, 95% CI 0.08, 027; P<0.001). However, we did not observe a significant relationship between the IGF-1 SDS and BA-CA when the IGF-1 level was lower than -2 SDS (β 0.07, 95% CI -0.12, 0.26; P=0.454). After GH therapy, there was a significant positive association between the IGF-1 SDS and BA-CA when the IGF-1 level was lower than 2 SDS (β 0.20, 95% CI 0.12, 028; P<0.001). However, we did not observe a significant relationship between the IGF-1 SDS and BA-CA when the IGF-1 level was greater than 2 SDS (β -0.03, 95% CI -0.33, 0.27; P=0.866). Conclusion. BA is more delayed in short children and adolescents. There is a nonlinear relationship between IGF-1 and BA maturation in short children before and after GH treatment. These findings suggest that a low level of IGF-1 may contribute to BA delay in short children and adolescents.

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Section: Discussionmentioning

confidence: 99%

Association between Insulin‐Like Growth Factor‐1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

Zhao

Zhang

Chu

et al. 2020

BioMed Research International

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“…23 A recent systematic review browsed 658 relevant publications on age estimation based on hand-wrist radiograph; the analysis showed that "variations between studies from different parts of the world were moderate and that difference between GP skeletal age and chronological age rarely exceeded one year for the average of a group in single studies." 24 Although this method is not always accurate in different populations or age groups, 25 it remains predictable for chronological age and it is still widely used. The use of geometric morphometrics allows a wide application in fields like anatomy, ontogenetic and evolutionary allometry, growth and correlation between facial skeletal development and dental crowding.…”

Section: Discussionmentioning

confidence: 99%

Predictability of Craniofacial Skeletal Age with Geometric Morphometrics

Saadé¹,

Baron²,

Noujeim³

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:This study aims to estimate skeletal age of craniofacial shape obtained from cone beam computed tomography (CBCT)-defined facial and basicranial landmarks using geometric morphometrics method in a random sample of growing patients, and explore the correlation between craniofacial shape and skeletal age as determined from hand and wrist radiograph. Materials and methods:Generalized Procrustes analysis (GPA) of craniofacial shape with estimation of centroid size was performed on CBCTs of 48 growing patients (mean age 11.7 ± 1.5 years). Greulich and Pyle method for skeletal age assessment were used for correlation with centroid size. Correlation among the variables relied on Pearson's coefficient and its 95% confidence interval was estimated. The model's R² was calculated, (Cook's distances, Mahalanobis distances, leverage values, and studentized residuals) and multiple regression analysis performed using the Statistical Package for the Social Sciences (SPSS) version 22.Results: Mean skeletal age was 11.9 ± 2.4 years. Centroid size (151.5 ± 7.2) was significantly correlated with chronological age (R = 0.616, 95% CI 0.355-0.789, p < 0.01) and skeletal age (R = 0.605, 95 % CI 0.331-0.794, p < 0.01). Conclusion:A new equation for determining craniofacial skeletal age was developed, using the centroid size of the craniofacial frame, gender, and the known chronological age.Clinical significance: A CBCT may be used for skeletal age assessment without additional hand wrist radiograph.

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“…Dabei war ein relativ niedriger SES immer mit einer zurückgebliebenen Skelettentwicklung verbunden. Die Methodik der Erfassung des SES sowie die Altersspanne der Kohorten variiert jedoch deutlich [29][30][31]. So rekrutierten Linhares et al etwa ihr Kollektiv in Brasilien im Jahr 1986 an Kindern, mit denen sie beim Schuheputzen oder Betteln in Kontakt kamen.…”

Section: Introductionunclassified

“…In Bezug auf die Altersspanne des untersuchten Kollektivs ist festzustellen, dass beispielsweise Elamin et al im Jahr 2017 im NordsudaneinKollektiv im Alter vom 3 bis 25 Jahren untersuchten. Damit sind in dieser Studie auch wesentlich jüngere Kinder als in der vorliegenden Arbeit untersucht worden [30]. Den SES ermittelten Elamin et al über die Art der Krankenversicherung bzw.…”

Section: Introductionunclassified

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Zur Altersdiagnostik lebender Personen: der Einfluss des sozioökonomischen Status auf die Skelett- und Zahnentwicklung in einer deutschen Studienkohorte

et al. 2020

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ZusammenfassungDie forensische Altersdiagnostik kann ein entscheidendes Instrument zur Durchführung rechtstaatlicher Verfahren sein. Bei der Altersdiagnostik wird die Entwicklung von Skelett- und Zahnmerkmalen einer zu begutachtenden Person mit Daten von Referenzpopulationen verglichen. Als möglicher Einflussfaktor auf die Altersdiagnose ist der sozioökonomische Status (SES) der zu begutachtenden Person zu berücksichtigen. Allerdings ist die Studienlage zu diesem Einflussfaktor bislang spärlich. Prospektiv wurde der Zusammenhang zwischen der Skelett- bzw. Zahnentwicklung und dem SES innerhalb einer deutschen Studienpopulation aus freiwilligen Teilnehmern ermittelt. Dazu wurde die Entwicklung der medialen Epiphyse des Schlüsselbeins, der distalen Epiphyse des Radius, der distalen Epiphyse des Femurs, der proximalen Epiphyse der Tibia und des linken unteren dritten Molaren bei 294 Frauen und 287 Männern im Alter von 12 bis 24 Jahren mittels 3‑Tesla-Magnetresonanztomographie (MRT) untersucht. Zusätzlich wurde der SES der Teilnehmer erfasst. Hierzu wurde das Bildungsniveau der Eltern erfragt. Der Einfluss des SES auf die Einzelmerkmale sowie die Gesamtheit der untersuchten Skelettmerkmale wurde mittels linearer Regression ermittelt. Für alle untersuchten Merkmale und Kombinationen konnte keine Evidenz für einen Zusammenhang festgestellt werden. Es wurde geschlussfolgert, dass sich die Lebensumstände der Studienteilnehmer offenbar nicht ausreichend stark unterschieden, um einen Einfluss des SES auf das Skelettalter darzustellen.

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Skeletal maturity of the hand in an East African group from Sudan

Abstract: There were statistically significant skeletal delays in North Sudanese males and most pre-menarche females, low height and low SES groups. Post-menarche females were advanced relative to males and GP references. Low SES impacts were statistically correlated to skeletal delay.

Cited by 12 publications

References 45 publications

Association between Insulin‐Like Growth Factor‐1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

Association between Insulin‐Like Growth Factor‐1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

Predictability of Craniofacial Skeletal Age with Geometric Morphometrics

Zur Altersdiagnostik lebender Personen: der Einfluss des sozioökonomischen Status auf die Skelett- und Zahnentwicklung in einer deutschen Studienkohorte

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