Skeletal metabolism in early infancy: Urinary hydroxyproline

Klein, L.; Teree, Thomas M.

doi:10.1016/s0022-3476(66)80330-x

Cited by 24 publications

(8 citation statements)

References 22 publications

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“…The values of urinary hydroxyproline excretion reported here for normal infants are similar to those recently reported in the literature. KLEIN and TERRE [12] found levels of excretion of 7.9-21.0 mg/ 24 h in five infants one to three days of age, and ALLISON et al…”

Section: Discussionmentioning

confidence: 90%

Excretion of Hydroxyproline in Urine by Premature and Normal Full-Term Infants and Those with Intrauterine Growth Retardation During the First Three Days of Life

Younoszai

Haworth

1968

Pediatr Res

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ExtractThe mean daily urinary excretion of hydroxyproiine on the first day of life was 4.4 mg/24 h for 50 fullterm normal infants, 3.5mg/24hfor 17 full-term infants with intrauterine growth retardation (IUGR) and 5.5 mg/24 h for 17 premature infants. The differences were not statistically significant. On the third day of life, all infants excreted significantly higher amounts of hydroxyproiine in their urine. The mean amount excreted by full-term normal infants and by premature infants was about the same, 9.9 mg/24 h and 9.6 mg/24 h, respectively, significantly more than that excreted by IUGR infants, 7.0 mg/24 h.Fifteen full-term normal infants fed a soya formula for the first week of life excreted almost the same amount of endogenous creatinine in the urine on the first, third and seventh day of life. The means in mg/24 h were 24.2, 24.3 and 22.5, respectively. The hydroxyproiine to creatinine ratio doubled on the third day of life. SpeculationThe increase in the amount of hydroxyproiine excreted in urine during the first few days of life may prove to be of value in assessing normal and abnormal rates of perinatal growth. Measurements of the amount of hydroxyproiine in urine may provide a good index of perinatal growth, and the rapid increase in excretion soon after birth seems to indicate the initiation of a phase of rapid growth. Introductionproline during infancy, childhood and adolescence has been defined and it has been shown that during periods The rate of urinary excretion of endogenous hydroxy-of rapid linear growth, the amount of total hydroxyproiine, both free and in peptide form, is related to the proline excreted increases [8,9,26]. There is little inmetabolic state and total mass of body collagen [2, 13, formation, however, about hydroxyproiine excretion 21]. A major part of body collagen is contained in bone, during the first few days of life. The purpose of this and the rate of turnover of collagen in bone exceeds study was to establish for the normal full-term infants that in other tissues [19]. It has been assumed, there-the hydroxyproiine excretion in urine during the first fore, that urinary excretion of hydroxyproiine mainly three days of life and to compare these values with those reflects the rate of metabolism of collagen in bone [5, found in patients with intrauterine growth retardation 7,10,11,18]. The normal range of urinary hydroxy-(IUGR) and in premature infants.

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Section: Discussionmentioning

confidence: 90%

Excretion of Hydroxyproline in Urine by Premature and Normal Full-Term Infants and Those with Intrauterine Growth Retardation During the First Three Days of Life

Younoszai

Haworth

1968

Pediatr Res

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“…The rate of urinary excretion of hydroxyproline has been shown to correlate directly with increased rates of collagen synthesis, such as occur during periods of rapid growth in infancy.'o. [25][26][27] Several structurally different types of collagen have been identified. Type I and Type 111 are the most abundant collagens of the pulmonary interstitium.…”

Section: Term2327mentioning

confidence: 99%

Dexamethasone treatment suppresses collagen synthesis in infants with bronchopulmonary dysplasia

Chari

McCulloch

et al. 1993

Pediatric Pulmonology

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Collagen is an essential component of connective tissue and is present in the pulmonary interstitium. Collagen deposition is known to increase in many acquired chronic diseases, including bronchopulmonary dysplasia (BPD). Urinary excretion of hydroxyproline has been used as a specific index of collagen synthesis. Many studies have demonstrated that dexamethasone therapy is associated with respiratory improvement in infants with BDP but the mechanism of this effect is not well understood. We postulated that in infants with BDP who receive dexamethasone, suppression of collagen synthesis may cause respiratory improvement. Therefore, we studied the effect of dexamethasone on respiratory status and urinary excretion of hydroxyproline in 14 ventilator-dependent infants with BDP. Infants received 0.5 mg/kg/day dexamethasone, tapered by half every 3 days to complete a 12 day course. Eleven of the 14 infants were extubated at a mean +/- SD of 8.7 +/- 4.9 days after starting dexamethasone. Mean urinary hydroxyproline/creatinine ratios at 3, 6, 9, and 12 days of dexamethasone therapy were significantly lower than the mean pretreatment value, but after discontinuation rapidly rose toward baseline values. Decreased urinary excretion of hydroxyproline indicates that dexamethasone suppressed collagen synthesis in these infants. We speculate that suppression of collagen synthesis reduced pulmonary inflammation and fibrosis, resulting in respiratory improvement.

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“…Free hydroxyproline excrction in early childhood forms nearly half of the total hydroxyproline ( 284,286). Free hydroxyproline is found in the plasma and it has been suggested that the increased free hydroxyproline in plasma and urine in early childhood is due to lower hydroxyproline oxidase activity ( 359 ) or to immature renal function (360).…”

Section: (209) Proline Tolerance Tests In the Hydroxyprolinemic Patientmentioning

confidence: 99%

Biochemistry of the Hydroxyprolines

Kuttan¹,

Radhakrishnan²

1973

Advances in Enzymology - And Related Areas of Molecular Biology

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Skeletal metabolism in early infancy: Urinary hydroxyproline

Cited by 24 publications

References 22 publications

Excretion of Hydroxyproline in Urine by Premature and Normal Full-Term Infants and Those with Intrauterine Growth Retardation During the First Three Days of Life

Excretion of Hydroxyproline in Urine by Premature and Normal Full-Term Infants and Those with Intrauterine Growth Retardation During the First Three Days of Life

Dexamethasone treatment suppresses collagen synthesis in infants with bronchopulmonary dysplasia

Biochemistry of the Hydroxyprolines

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