Skeletal Muscle Abnormalities in Chronic Heart Failure Patients: Relation to Exercise Capacity and Therapeutic Implications

Nicoletti, Ilaria; Cicoira, M.; Zanolla, Luisa; Franceschini, Lorenzo; Brighetti, Giovanna; Pilati, Maria; Zardini, Piero

doi:10.1111/j.1527-5299.2002.01219.x

Cited by 27 publications

(18 citation statements)

References 60 publications

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“…This suggests that CHF causes intrinsic defects in skeletal muscles, and numerous studies have reported important functional and biochemical changes in skeletal muscle cells associated with CHF (for recent reviews, see Refs. 202,289,330). These changes may affect fatigue development by acting both on myofibrillar function and on SR Ca 2ϩ handling (287,288,372,457).…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Fatigue: Cellular Mechanisms

Allen¹,

Lamb²,

Westerblad³

2008

Physiological Reviews

1,896

1,876

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Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Many muscle properties change during fatigue including the action potential, extracellular and intracellular ions, and many intracellular metabolites. A range of mechanisms have been identified that contribute to the decline of performance. The traditional explanation, accumulation of intracellular lactate and hydrogen ions causing impaired function of the contractile proteins, is probably of limited importance in mammals. Alternative explanations that will be considered are the effects of ionic changes on the action potential, failure of SR Ca2+ release by various mechanisms, and the effects of reactive oxygen species. Many different activities lead to fatigue, and an important challenge is to identify the various mechanisms that contribute under different circumstances. Most of the mechanistic studies of fatigue are on isolated animal tissues, and another major challenge is to use the knowledge generated in these studies to identify the mechanisms of fatigue in intact animals and particularly in human diseases.

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Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Fatigue: Cellular Mechanisms

Allen¹,

Lamb²,

Westerblad³

2008

Physiological Reviews

1,896

1,876

View full text Add to dashboard Cite

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“…114 Physical therapists receive training on the use of NMES during their professional education and must demonstrate competency. The NMES unit is a handheld device that is oftentimes readily available to physical therapists.…”

Section: Functional Neuromuscular Electronic Stimulationmentioning

confidence: 99%

“…The substantial decline in functional capacity is one of the primary and most debilitating consequences of HF. Cardiac function and skeletal [114][115][116][117] and respiratory [118][119][120] myopathy all contribute to fatigue and decreased physical exertion capabilities in the HF population. This is particularly relevant to frail HF patients, in whom functional disability is likely to be advanced.…”

Section: Exercise Recommendations Effects Of Hf On Functional Capacitymentioning

confidence: 99%

Heart Failure Management in Skilled Nursing Facilities

Jurgens¹,

Goodlin²,

Dolansky³

et al. 2015

Circ: Heart Failure

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655H eart failure (HF) is a complex syndrome in which structural or functional cardiac abnormalities impair the filling of ventricles or left ventricular ejection of blood. HF disproportionately occurs in those ≥65 years of age.1 Among the estimated 1.5 to 2 million residents in skilled nursing facilities (SNFs) in the United States, cardiovascular disease is the largest diagnostic category, and HF is common. 2,3Despite the high prevalence of HF in SNF residents, none of the large randomized clinical trials of HF therapy included SNF residents, and very few included patients >80 years of age with complex comorbidities.Several issues make it important to address HF care in SNFs. The healthcare environment and characteristics of SNF residents are distinct from those of community-dwelling adults. Comorbid illness unrelated to HF (eg, dementia, hip fracture) increases with age >75 years, and these conditions may complicate both the initial HF diagnosis and ongoing management. [4][5][6] Morbidity and mortality rates are significantly increased for hospitalized older adults with HF discharged to SNFs compared with those discharged to other sites. 7Transitions between hospitals and SNFs may be problematic. 8SNF 30-day rehospitalization rates for HF range from 27% to 43%, 7,9,10 and long-term care residents sent to the emergency department are at increased risk for hospital admission and death.11 The purpose of this scientific statement is to provide guidance for management of HF in SNFs to improve patientcentered outcomes and reduce hospitalizations. This statement addresses unique issues of SNF care and adapts HF guidelines and other recommendations to this setting. MethodsThis scientific statement on HF management in SNFs was developed by a writing group of experts representing nursing, medicine (cardiology, geriatrics, nursing home physicians, and palliative medicine), pharmacology, physical therapy, dietary clinical management, research, and quality of care. Sponsors (the American Heart Association [AHA] and the Heart Failure Society of America) identified specific members of the writing group, and others were selected on the basis of known expertise. A literature search was performed using the key The current document is solely the responsibility of the authors and does not represent the official views of the National Heart, Lung, and Blood Institute or the Department of Health and Human Services.The American Heart Association and the Heart Failure Society of America make every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This document was approved by the American Heart Association Science Advisory and Coordinating Committee on September 15, 2014, and by the...

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“…Em seguida, surgiram estudos que avaliaram alterações metabólicas intrínsecas ao tecido muscular, em especial a taxa de utilização dos fosfatos de alta energia (MANCINI et al, 1989). Com a evolução do conhecimento sobre o tema, atualmente já conhecemos diversas alterações morfofuncionais da musculatura esquelética desencadeadas por um quadro de disfunção cardíaca (NICOLETTI et al, 2003), bem como alguns efeitos do TFA (ADAMS, DORING e SCHULER, 2008;BACURAU et al, 2009). Entretanto, nenhum estudo até o presente momento comparou de forma sistemática os efeitos do TFA em alta intensidade com o TFA em intensidade moderada na musculatura esquelética em situações de disfunção cardíaca.…”

Section: Musculatura Esqueléticaunclassified

Efeitos do treinamento físico aeróbio em alta intensidade na musculatura esquelética de ratos infartados

Moreira¹

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Prof. Dr. Instituição:Julgamento: Assinatura:Prof. Dr. Instituição:Julgamento: Assinatura:Dedico este trabalho a três pessoas fundamentais em todos os meus passos:À Camila, minha esposa e companheira de todas as horas, por todo amor e carinho.Agradeço pela compreensão nos finais de semana que passei trabalhando e pelas madrugadas com a luz acesa. Tenha a certeza de que tudo isso valerá a pena e que todos os nossos planos se concretizarão num futuro muito breve. Eu te amo! Aos meus pais, José Maria e Maria Célia, pelo amor, carinho e incentivo desde o primeiro dia de minha vida. AGRADECIMENTOSÀ Patricia Brum, por seu papel essencial no meu crescimento profissional, por seu profissionalismo e pelas conversas que tivemos, científicas ou não. Agradeço também pelo suco com uvas dentro, oferecido durante as reuniões.Aos meus irmãos Marcelo e Matheus.Aos meus grandes amigos José Braga, Fabiola, Arthur e Bernardo.À minha avó Juracy e aos meus padrinhos Ilza e Sirley pelo amor e suporte incondicionais.A todos os meus tios, tias e primos pela torcida por meu sucesso e pelo apoio de todas as horas.À minha segunda família, Elza, Dimas e Carol pelo carinho e consideração.Aos meus colegas de laboratório, Luiz Bozi, Luiz Bechara, Vanessa, Aline, Paulo, Dani, Telma, Nathalie, Chris, Julio, Juliane, Katia, Max e Fabi, pela colaboração, pelas piadas, pelos finais de semana e madrugadas trabalhando.Aos professores Paulo Ramires, Edilamar e seus alunos.Aos técnicos Alex, Ney, Marcele, Katt, Luciano e Glória, pelo trabalho essencial no desenvolvimento de todos os projetos do laboratório.À secretaria de Pós-Graduação da Escola de Educação Física e Esporte da USP, especialmente à Ilza, ao Marcio e ao Paulo, pela eficiência e prontidão nos esclarecimentos relacionados ao Programa de Mestrado.Aos meus mais novos amigos e colegas de trabalho, Natale e Gustavo, por todo suporte e conselhos.À FAPESP e ao CNPq pelo suporte financeiro. "You can be wrong on your hypothesis, but you cannot be wrong on your data. And I was not wrong on data"Eduardo Moacyr Krieger, em palestra proferida na reunião anual da A miopatia esquelética em doenças sistêmicas é um importante preditor de mortalidade e prognóstico em diversas síndromes, incluindo a insuficiência cardíaca. Os danos músculo-esqueléticos em situações de comprometimento cardíaco são descritos pela literatura há décadas, entretanto, nenhum recurso farmacológico proposto até o momento mostrou-se eficiente em reverter esses prejuízos, ressaltando o papel do treinamento físico aeróbio. Apesar dos inegáveis benefícios desta terapia adjuvante no tratamento da insuficiência cardíaca, muito pouco se sabe sobre a intensidade de exercício capaz de otimizar os ganhos promovidos por esta intervenção. Dado isso, nesse estudo avaliamos a eficácia do treinamento físico aeróbio em alta intensidade na musculatura esquelética em ratos submetidos ao infarto do miocárdio, comparando-a com protocolo isocalórico realizado em intensidade moderada. Observamos que os animais infartados apresentaram alterações patológi...

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Skeletal Muscle Abnormalities in Chronic Heart Failure Patients: Relation to Exercise Capacity and Therapeutic Implications

Cited by 27 publications

References 60 publications

Skeletal Muscle Fatigue: Cellular Mechanisms

Skeletal Muscle Fatigue: Cellular Mechanisms

Heart Failure Management in Skilled Nursing Facilities

Efeitos do treinamento físico aeróbio em alta intensidade na musculatura esquelética de ratos infartados

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