Skeletal Muscle Adaptations to Exercise Training in Young and Aged Horses

Latham, Christine M.; Owen, Randi N; Dickson, E.C.; Guy, Chloey P; White-Springer, Sarah H

doi:10.3389/fragi.2021.708918

Cited by 5 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the racing industry, it is essential to start race training at a young age to properly adapt their musculoskeletal system accordingly [ 26 , 27 ]. The age at the start and the joint health status are crucial factors, alongside other debatable factors such as the exercise type, foot-surface interaction, intensity, duration etc.…”

Section: Discussionmentioning

confidence: 99%

Salivary biglycan-neo-epitope-BGN262: A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface arena

Adepu¹,

Lord²,

Hugoh³

et al. 2023

Osteoarthritis and Cartilage Open

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Salivary biglycan-neo-epitope-BGN262: A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface arena

Adepu¹,

Lord²,

Hugoh³

et al. 2023

Osteoarthritis and Cartilage Open

View full text Add to dashboard Cite

“…Although this result was expected, one must keep in mind here when interpreting the results that the classification system used by Henneke [ 8 ] has discrepancies. Firstly, it was developed for Quarter Horse mares and is not ideally suited for Warmblood horses [ 10 ]; in addition, it is not entirely optimal for obese horses [ 29 , 30 ]. In this study, not only were different breeds of horses represented, including Coldblood horses and breed mixes, but some animals also fell between two scores, which made classification using this system difficult.…”

Section: Discussionmentioning

confidence: 99%

Morphometric Measurements and Muscle Atrophy Scoring as a Tool to Predict Body Weight and Condition of Horses

Urbanek,

Zebeli

2023

Veterinary Sciences

View full text Add to dashboard Cite

Accurate estimation of body weight (BW) and condition (BCS) is important in the equine practice. The main goal of this research was to develop models for the prediction of BW and BCS of horses in the practice using both common morphometric measurements and measurements of Cresty Neck Score (CNS) and Muscle Atrophy Scoring System (MASS) as a measure of muscularity. Our model showed that the BW of horses could be predicted with high reproducibility (concordance correlation coefficient = 0.97), accuracy (0.99), and precision (0.97) using the morphometric measurements of the height at withers, circumference of the chest, cane circumference, body length, and body circumference as well as the BCS, CNS, and muscle atrophy score of the hindlimbs. The stepwise multiple regression analysis revealed that the BCS of horses can be predicted with the data of parameters such as age, body length and an index consisting of measurements of the body circumference to height of withers, and the atrophy of the neck. Future research should use larger cohorts of animals to validate the findings of this study.

show abstract

“…has proven that the CS activity increases only after high-intensity exercise [61]. In addition, some studies have noted impaired mitochondrial function and adaptation to physical activity in aged animals [62].…”

Section: Of 20mentioning

confidence: 99%

Effects of Treadmill Running at Different Light Cycles in Mice with Metabolic Disorders

Zakharova,

Milovanova,

Orlova

et al. 2023

IJMS

View full text Add to dashboard Cite

Type 2 diabetes mellitus accounts for about 90% of cases of diabetes and is considered one of the most important problems of our time. Despite a significant number of studies on glucose metabolism, the molecular mechanisms of its regulation in health and disease remain insufficiently studied. That is why non-drug treatment of metabolic disorders is of great relevance, including physical activity. Metabolic changes under the influence of physical activity are very complex and are still difficult to understand. This study aims to deepen the understanding of the effect of physical exercise on metabolic changes in mice with diabetes mellitus. We studied the effect of forced treadmill running on body weight and metabolic parameters in mice with metabolic disorders. We developed a high-fat-diet-induced diabetic model of metabolic disorders. We exposed mice to forced treadmill running for 4 weeks. We determined glucose and insulin levels in the blood plasma biochemically and analyzed Glut-4 and citrate synthase in M. gastrocnemius muscle tissue using Western blotting. The research results show that daily treadmill running has different effects on different age groups of mice with metabolic disorders. In young-age animals, forced running has a more pronounced effect on body weight. At week 12, young obese mice had a 17% decrease in body weight. Body weight did not change in old mice. Moreover, at weeks 14 and 16, the decrease in body weight was more significant in the young mice (by 17%) compared to the old mice (by 6%) (p < 0.05). In older animals, it influences the rate of glucose uptake. At 60 min, the blood glucose in the exercised older mice decreased to 14.46 mmol/L, while the glucose concentration in the non-exercised group remained at 17 mmol/L. By 120 min, in mice subjected to exercise, the blood glucose approached the initial value (6.92 mmol/L) and amounted to 8.35 mmol/L. In the non-exercised group, this difference was 45%. The effects of physical activity depend on the time of day. The greater effect is observed when performing shift training or exercise during the time when animals are passive (light phase). In young mice, light phase training had a significant effect on increasing the content of Glut-4 in muscle tissue (84.3 ± 11.3%, p < 0.05 with control group—59.3 ± 7.8%). In aged mice, shift training caused an increase in the level of Glut-4 in muscle tissue (71.3 ± 4.1%, p < 0.05 with control group—56.4 ± 10,9%). In the group of aged mice, a lower CS level was noticed in all groups in comparison with young mice. It should also be noted that we observed that CS increased during exercise in the group of young mice, especially during light phase training. The CS content in the light phase subgroup (135.8 ± 7.0%) was higher than in the dark phase subgroup (113.3 ± 7.7%) (p = 0.0006). The CS decreased in aged chow-fed mice and increased in the high-fat-fed group. The CS content in the chow diet group (58.2 ± 5.0%) was 38% lower than in the HFD group (94.9 ± 8.8%).

show abstract

Skeletal Muscle Adaptations to Exercise Training in Young and Aged Horses

Cited by 5 publications

References 47 publications

Salivary biglycan-neo-epitope-BGN262: A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface arena

Salivary biglycan-neo-epitope-BGN262: A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface arena

Morphometric Measurements and Muscle Atrophy Scoring as a Tool to Predict Body Weight and Condition of Horses

Effects of Treadmill Running at Different Light Cycles in Mice with Metabolic Disorders

Contact Info

Product

Resources

About