Skeletal Muscle and Organ Weights of Aged and Trained Male Rats

McCafferty, William B.; Edington, Dee W.

doi:10.1159/000211997

Cited by 28 publications

(6 citation statements)

References 4 publications

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“…The decreased LV hypertrophic response in old rats is compatible with the results in a pressure overload experimental model previously reported by our laboratory (9). McCafferty and Edington (8) have reported that in animal models of exercise, the cardiac hypertrophic response in the senescent was less compared with the young adult animals. On the other hand, Florini et al (6) and Zitnik and Roth (7) have reported that hormonal stimulation (thyroid hormone) caused a similar extent of hypertrophy in old rats and old mice compared with young adult animals (6, 7).…”

Section: Resultssupporting

confidence: 90%

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Effect of age on myocardial adaptation to volume overload in the rat.

Isoyama

Grossman²,

Wei³

1988

J. Clin. Invest.

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To test the hypothesis that the capacity for left ventricular (LV) adaptation to volume overload might diminish with age, we examined the hemodynamics and degree of myocardial hypertrophy in response to aortic insufficiency in young adult (9 mo) and old (18 or 22 mo) Fischer rats. Before, immediately after, and at 2 and 4 wk after creating aortic insufficiency, LV and aortic pressures were measured using a catheterization technique. 4 wk after surgery, we measured aortic flow, and estimated the LV passive pressure-volume relationship and the degree of LV hypertrophy after killing. Immediately after the surgical creation of aortic insufficiency, both young and old rats showed similar elevation of LV end-diastolic pressure (from 4.8±0.6 to 12.0±1.5 mmHg in the young rats, P < 0.01; from 4.9±0.4 to 11.0±0.7 mmHg in the old rats, P < 0.01). In the young rats LV, end-diastolic pressure decreased to 8.0±1.0 and to 8.5±0.9 mmHg at 2 and 4 wk (P < 0.05). In contrast, LV end-diastolic pressure at 2 (16.9±3.1 mmHg) and 4 wk (16.1±2.7 mmHg) in the old rats was even higher, compared with the values measured immediately after aortic insufficiency. At 4 wk, LV end-diastolic meridional wall stress (calculated from the in vivo LV end-diastolic pressure, and the pressure-volume relationship and muscle mass obtained after killing) was higher in the old rats than in the young rats. In the young rats, the diastolic pressure-volume relationship at 4 wk shifted to the right (P < 0.01), and LV dry weight, LV dry weight/tibial length, and protein content of the LV myocardium increased by 26% (P < 0.01), 24% (P < 0.01), and 33% (P < 0.01), respectively. However, old rats with aortic insufficiency did not show a significant change in the pressure-volume relationship, dry weight, or protein content at 4 wk. These results suggest that advanced age diminishes the capacity for LV hypertrophy in response to a volume overload, and this reduced LV hypertrophic response in the old rats resulted in persistent elevation of LV end-diastolic pressure and wall stress.

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Section: Resultssupporting

confidence: 90%

“…Additionally, aging per se results in a modest increase in heart weights and in the size of individual myocytes in humans and animals (8,(12)(13)(14)(15)(16)(17). This age-associated change is functionally similar to that produced by pressure overload (12,14).…”

Section: Introductionmentioning

confidence: 99%

Effect of age on myocardial adaptation to volume overload in the rat.

Isoyama

Grossman²,

Wei³

1988

J. Clin. Invest.

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“…1). The continued weight gain of this strain of Sprague-Dawley rat [Crl :COBSIaiCDIm(SD)] over the life span has been documented previously [29,12]. Table I contains mean values of the rates of oxidation catalyzed by gastrocnemius muscle homogenates from four groups of rats oxidizing six substrates in the presence of ADP.…”

Section: Body Weightmentioning

confidence: 99%

Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat

Beyer

Starnes

Edington

et al. 1984

Mechanisms of Ageing and Development

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The ability of gastrocnemius muscle homogenates to catalyze the oxidation of succinate, glutamate + malate, pyruvate + malate, palmitoyl-coenzyme A, decanoylcarnitine and palmitoylcarnitine in the presence of ADP decreased by approximately 32% in sedentary male Sprague-Dawley rats between the ages of 9 and 25 months. Following 21 weeks of treadmill training (running), such homogenates from 25-month-old animals catalyzed oxidations 55% more rapidly than those from 25-month-old sedentary rats, and 17% faster than those from 9-month-old sedentary rats. Total and peptide-bound flavin of gastrocnemius muscles also declined between 9 and 25 months of age and were elevated in the 25-month-old endurance trained rats to levels greater than both 9- and 25-month-old sedentary animals. The yield of protein in the mitochondrial fraction from the quadriceps femoris muscle decreased between 9 and 25 months and was restored to the 9-month level by endurance training. The kinetic characteristics of the isolated mitochondria were not influenced by age or exercise. These data indicate that 2-year-old rats retain the capacity to increase skeletal muscle oxidative capacity and mitochondrial population density in response to endurance training.

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“…McCafferty and Edington (1974) also reported an increased heart weight with running in young and middle aged rats (90, 150, 300, and 450 days old). However, in old rats (600 days old) the exercised animals had lower heart weights than did the controls.…”

Section: -20mentioning

confidence: 82%

Effects of exercise upon circulating thyroxine serum and hepatic lipid concentrations, heart, and seminal vesicles in rats and of age and exercise upon circulating thyroxine in humans

Auth

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Skeletal Muscle and Organ Weights of Aged and Trained Male Rats

Cited by 28 publications

References 4 publications

Effect of age on myocardial adaptation to volume overload in the rat.

Effect of age on myocardial adaptation to volume overload in the rat.

Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat

Effects of exercise upon circulating thyroxine serum and hepatic lipid concentrations, heart, and seminal vesicles in rats and of age and exercise upon circulating thyroxine in humans

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