Skeletal muscle blood flow and flow heterogeneity  during dynamic and isometric exercise in humans

Laaksonen, Marko S.; Kalliokoski, Kari K.; Kyröläinen, Heikki; Kemppainen, Jukka; Teräs, Mika; Sipilä, Hannu; Nuutila, Pirjo; Knuuti, Juhani

doi:10.1152/ajpheart.00714.2002

Cited by 83 publications

(86 citation statements)

References 34 publications

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“…Pincivero et al (2006) showed similar EMG amplitudes between the VL, VM and rectus femoris muscles during the concentric phase of KE contractions (similar to the contraction phase of the present KE), suggesting a similar activation of each muscle. In addition, Laaksonen et al (2003) observed no difference in blood flow between the VL and VM during dynamic KE exercise. Thus, it appears that the mosaic pattern and heterogeneity of human muscles with respect to fiber type makeup and the similar activation patterns of the VL and VM during KE may serve to attenuate any perfusion to metabolism mismatching that may occur in this model.…”

Section: Discussionmentioning

confidence: 80%

Kinetics of VO2 limb blood flow and regional muscle deoxygenation in young adults during moderate intensity, knee-extension exercise

et al. 2009

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The kinetics of pulmonary O(2) uptake (VO(2p)), limb blood flow (LBF) and deoxygenation (DeltaHHb) of the vastus lateralis (VL) and vastus medialis (VM) muscles during the transition to moderate-intensity knee-extension exercise (MOD) was examined. Seven males (27 +/- 5 years; mean +/- SD) performed repeated step transitions (n = 4) from passive exercise to MOD. Breath by breath VO(2p) femoral artery LBF, and VL and VM muscle DeltaHHb were measured, respectively, by mass spectrometer and volume turbine, Doppler ultrasound and near-infrared spectroscopy. Phase 2 VO(2p), LBF, and HHb data were fit with a mono-exponential model. The time constant (tau) of the VO(2p) and LBF response were not different (tauVO(2p), 24 +/- 6 s; tauLBF, 23 +/- 8 s). The DeltaHHb response did not differ between VL and VM in amplitude (VL 6.97 +/- 4.22 a.u.; VM 7.24 +/- 3.99 a.u.), time delay (DeltaHHb(TD): VL 17 +/- 2 s; VM 15 +/- 1 s), time constant (tauDeltaHHb: VL 11 +/- 6 s; VM 13 +/- 4 s), or effective time constant [tau'DeltaHHb (= DeltaHHb(TD) + tauDeltaHHb): VL 28 +/- 7 s; VM 28 +/- 4 s]. Adjustments in DeltaHHb in VL and VM depict a similar balance of regional O(2) delivery and utilization within the quadriceps muscle group. The tau'DeltaHHb and tauVO(2p) were similar, however, the DeltaHHb displayed an "overshoot" relative to the steady-state levels reflecting a slower alteration of microvascular blood flow (O(2) delivery) relative to O(2) utilization, necessitating a greater reliance on O(2) extraction.

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Section: Discussionmentioning

confidence: 80%

Kinetics of VO2 limb blood flow and regional muscle deoxygenation in young adults during moderate intensity, knee-extension exercise

et al. 2009

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“…Nevertheless, the similarity of NIRS-derived oxygen saturation at 60 and 100% MVC during exercise (Fig. 5) and the comparable postexercise hyperemic response of MBF and TOI may (see below for a conflicting perspective) support the suggestion (31) that IMP at 60% MVC is sufficient to occlude blood flow to the contracting muscle, most likely at the lower-order arterioles or the capillary bed (15,28).…”

Section: Discussionmentioning

confidence: 84%

Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions

McNeil

Allen

Olympico

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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McNeil CJ, Allen MD, Olympico E, Shoemaker JK, Rice CL. Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions. Am J Physiol Regul Integr Comp Physiol 309: R475-R481, 2015. First published June 17, 2015 doi:10.1152/ajpregu.00387.2014.-A reduction of blood flow to active muscle will precipitate fatigue, and sustained isometric contractions produce intramuscular and compartmental pressures that can limit flow. The present study explored how blood flow and muscle oxygenation respond to isometric contractions at low, moderate, and maximal intensities. Over two visits, 10 males (26 Ϯ 2 yr; means Ϯ SD) performed 1-min dorsiflexion contractions at 30, 60, and 100% of maximal voluntary contraction (MVC) torque. Doppler ultrasound of the anterior tibial artery was used to record arterial diameter and mean blood velocity and to calculate absolute blood flow. The tissue oxygenation index (TOI) of tibialis anterior was acquired with nearinfrared spectroscopy (NIRS). There was a progressive increase in blood flow at 30% MVC (peak of 289 Ϯ 139% resting value), no change from rest until an increase in the final 10 s of exercise at 60% MVC (peak of 197 Ϯ 102% rest), and an initial decrease (59 Ϯ 30% resting value) followed by a progressive increase at 100% MVC (peak of 355 Ϯ 133% rest). Blood flow was greater at 30 and 100% than 60% MVC during the last 30 s of exercise. TOI was ϳ63% at rest and, within 30 s of exercise, reached steady-state values of ϳ42%, ϳ22%, and ϳ22% for 30, 60, and 100% MVC, respectively. Even maximal contraction of the dorsiflexors is unable to cause more than a transient decrease of flow in the anterior tibial artery. Unlike dynamic or intermittent isometric exercise, our results indicate blood flow is not linearly graded with intensity or directly coupled with oxygenation during sustained isometric contractions.dorsiflexors; muscle blood flow; near-infrared spectroscopy

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“…This increase was observed in both groups and for both veins. Dynamic exercise causes higher and less heterogeneous blood flow than intermittent isometric exercise at the same exercise intensity (Laaksonen, Kalliokoski et al, 2002). During exercise the contraction rhythm of peripheral skeletal muscles results in the compression of intramuscular veins, granting the venous blood a considerable amount of kinetic energy that facilitates its return to the heart (Stewart, Medow, et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Influence of wearing an unstable shoe on thigh and leg muscle activity and venous response in upright standing

et al. 2012

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Purpose: To quantify the effect of unstable shoe wearing on muscle activity and haemodynamic response during standing.Methods: Thirty volunteers were divided into 2 groups: the experimental group wore an unstable shoe for 8 weeks, while the control group used a conventional shoe for the same period. Muscle activity of the medial gastrocnemius, tibialis anterior, rectus femoris and biceps femoris and venous circulation were assessed in quiet standing with the unstable shoe and barefoot.Results: In the first measurement there was an increase in medial gastrocnemius activity in all volunteers while wearing the unstable shoe. On the other hand, after wearing the unstable shoe for eight weeks these differences were not verified. Venous return increased in subjects wearing the unstable shoe before and after training. Conclusions:The unstable shoe produced changes in electromyographic characteristics which were advantageous for venous circulation even after training accommodation by the neuromuscular system.

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Skeletal muscle blood flow and flow heterogeneity during dynamic and isometric exercise in humans

Cited by 83 publications

References 34 publications

Kinetics of VO2 limb blood flow and regional muscle deoxygenation in young adults during moderate intensity, knee-extension exercise

Kinetics of VO2 limb blood flow and regional muscle deoxygenation in young adults during moderate intensity, knee-extension exercise

Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions

Influence of wearing an unstable shoe on thigh and leg muscle activity and venous response in upright standing

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