Skeletal muscle blood flow in anaesthetized horses. Part II: effects of anaesthetics and vasoactive agents

Raisis, Anthea L.

doi:10.1111/j.1467-2995.2005.00192.x

Cited by 37 publications

(29 citation statements)

References 32 publications

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“…; Edner et al. ; Raisis ). However, α 2 ‐adrenoceptor agonists such as detomidine and dexmedetomidine increase peripheral vascular resistance by activating α 2 ‐adrenoceptors located on the smooth muscle cells of peripheral vessels (Elliott ; Snapir et al.…”

Section: Discussionmentioning

confidence: 99%

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Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Pakkanen

Raekallio

Mykkänen

et al. 2015

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

“…). In addition to the cardiovascular effects of α 2 ‐adrenoceptor agonists, volatile anaesthetic agents can also result in marked cardiovascular depression by reducing both myocardial contractility and peripheral vascular resistance (Steffey & Howland ; Raisis ; Blissitt et al. ).…”

Section: Introductionmentioning

confidence: 99%

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Pakkanen

Raekallio

Mykkänen

et al. 2015

Veterinary Anaesthesia and Analgesia

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“…Mechanical ventilation was not used in the current case, as it reduces venous return and cardiac output in anaesthetised patients (Raisis 2005), while the arterial blood gas values remained within normal clinical limits for anaesthetised horses during spontaneous breathing. However, in case of hypoxaemia or hypercapnia, mechanical ventilation would have been applied.…”

Section: Discussionmentioning

confidence: 99%

Horse: anaesthetic management for open castration of a Belgian draught horse with interventricular septum defect, aortic regurgitation and ventricular premature depolarisations

Cerasoli

Melis

Loon

et al. 2017

Vet Record Case Reports

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A 2 years and 11 months old Belgian draught horse stallion with a membranous ventricular septal defect, severe aortic regurgitation, mild left ventricular enlargement and ventricular premature depolarisations was anaesthetised to perform open castration. A balanced anaesthetic approach, involving intravenous use of romifidine (80 µg/kg), morphine (0.1 mg/kg) and lidocaine (1 mg/kg) for premedication, followed by induction of anaesthesia with ketamine (2.2 mg/kg) and midazolam (0.06 mg/kg) and maintenance with isoflurane, lidocaine CRI (50 µg/kg/min) and intratesticular lidocaine 2 per cent (10 ml in each testicle) was used to optimise the cardiovascular stability and enhance the safety of the procedure. A multimodal analgesic approach was provided, aiming to reduce the amount of isoflurane required to maintain a surgical plane of anaesthesia. A smooth and uneventful recovery was obtained. The present case report describes an anaesthetic protocol that could be applied in similar cases.

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“…19 However, compared with other domestic mammals under inhalation anesthesia, 15,20 systemic vascular resistance is substantially lower in rabbits receiving inhalation anesthetics. 19 However, compared with other domestic mammals under inhalation anesthesia, 15,20 systemic vascular resistance is substantially lower in rabbits receiving inhalation anesthetics.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular effects of equipotent doses of isoflurane alone and isoflurane plus fentanyl in New Zealand White rabbits (Oryctolagus cuniculus)

Tearney

Barter

Pypendop

2015

ajvr

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OBJECTIVE To determine effects of equipotent concentrations of fentanyl and isoflurane, compared with isoflurane alone, on cardiovascular variables in New Zealand White rabbits (Oryctolagus cuniculus). ANIMALS 6 adult female New Zealand White rabbits. PROCEDURES Rabbits were anesthetized with isoflurane, and lungs were mechanically ventilated. The minimum alveolar concentration (MAC) of isoflurane alone (baseline) and with fentanyl administered IV to achieve 3 targeted plasma concentrations was determined for each rabbit by means of an electrical stimulus. Cardiovascular variables were measured in a separate experiment at 1.3X isoflurane MAC and equipotent doses of isoflurane plus fentanyl at the same 3 targeted plasma concentrations. Blood samples were collected for measurement of blood gas variables and plasma fentanyl concentrations. Treatment effects were evaluated by repeated-measures ANOVA followed by 2-tailed paired t tests with sequentially rejective Bonferroni correction. RESULTS Mean ± SD MAC of isoflurane was 1.95 ± 0.27%. Mean measured plasma fentanyl concentrations of 4.97, 8.93, and 17.19 ng/mL reduced isoflurane MAC by 17%, 37%, and 56%, respectively. Mean measured plasma fentanyl concentrations during cardiovascular measurements were 5.49, 10.26, and 18.40 ng/mL. Compared with baseline measurements, heart rate was significantly lower at all 3 plasma fentanyl concentrations, mean arterial blood pressure and systemic vascular resistance were significantly higher at mean fentanyl concentrations of 10.26 and 18.40 ng/mL, and cardiac output was significantly higher at 18.40 ng of fentanyl/mL. CONCLUSIONS AND CLINICAL RELEVANCE Administration of fentanyl in isoflurane-anesthetized rabbits resulted in improved mean arterial blood pressure and cardiac output, compared with isoflurane alone. This balanced anesthesia technique may prove useful in the management of clinical cases in this species.

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Skeletal muscle blood flow in anaesthetized horses. Part II: effects of anaesthetics and vasoactive agents

Cited by 37 publications

References 32 publications

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Horse: anaesthetic management for open castration of a Belgian draught horse with interventricular septum defect, aortic regurgitation and ventricular premature depolarisations

Cardiovascular effects of equipotent doses of isoflurane alone and isoflurane plus fentanyl in New Zealand White rabbits (Oryctolagus cuniculus)

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