Skeletal Muscle Damage Produced by Electrically Evoked Muscle Contractions

Fouré, Alexandre; Gondin, Julien

doi:10.1249/jes.0000000000000239

Cited by 13 publications

(11 citation statements)

References 55 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute electrically stimulated eccentric (5.5‐fold) and isometric (3.7‐fold) exercise can increase muscle collagen mRNA levels more than concentric exercise (2‐fold) in animals (Heinemeier et al ., 2007), but this is unexplored in humans. It is also unknown whether increased muscle collagen mRNA levels were triggered by the higher forces inherent to eccentric (and isometric) contractions, provoked by the contraction mode itself, or associated with the greater muscle and ECM damage after electrically stimulated versus voluntary contractions (Fouré & Gondin, 2021). Rat muscle collagens III and IV also follow this pattern of changes in mRNA levels after eccentric exercise (downhill running) (Han et al ., 1999 a ; Koskinen et al ., 2001 a ).…”

Section: Collagensmentioning

confidence: 99%

“…CTGF and TGF‐β1 mRNA levels in rat gastrocnemius were higher after eccentric (TGF‐β1: 10‐fold, CTGF: 2.8‐fold) and isometric (TGF‐β1: 4‐fold, CTGF: 2.3‐fold) than concentric contractions (TGF‐β1: 2‐fold, CTGF: 1.2‐fold), with this pattern also observed for LO mRNA levels. However, it is unclear whether these changes were triggered by the higher forces inherent to eccentric (and isometric) contractions, the contraction mode, or possibly the greater muscle and ECM damage observed after electrically stimulated versus voluntary contractions (Heinemeier et al ., 2007; Fouré & Gondin, 2021). Interestingly, increases in CTGF and TGF‐β mRNA levels in VL muscle were almost identical when measured 3 h after 100 eccentric knee extensions in men, with CTGF increasing 7.6‐fold and TGF‐β2 transcripts increasing 7.8‐fold (Hyldahl et al ., 2015).…”

Section: Growth Factors Enzymes and Modulation Of Ecm Componentsmentioning

confidence: 99%

“…Of importance is that force production during the eccentric contractions was greater than during isometric contractions, which was greater than during concentric contractions. Moreover, electrical stimulation causes greater muscle damage than voluntary contractions, which would potentially cause further ECM disruption (Fouré & Gondin, 2021). Thus, it is not immediately clear whether the between‐condition differences were unique to contraction mode, reflected muscle tensile force, or were caused by greater muscle and ECM damage.…”

Section: Growth Factors Enzymes and Modulation Of Ecm Componentsmentioning

confidence: 99%

“…However, force production during eccentric contractions was greater than in isometric contractions, which was greater than in concentric contractions. It is therefore not immediately clear whether between‐condition differences were contraction mode dependent due to different muscle tension or due to the greater muscle and ECM damage after electrically stimulated versus voluntary contractions (Fouré & Gondin, 2021). Nevertheless, other studies have consistently shown increased TIMP mRNA levels in animal muscles after different forms of eccentric exercise that last up to 7 days (Koskinen et al ., 2001 a , 2002).…”

Section: Growth Factors Enzymes and Modulation Of Ecm Componentsmentioning

confidence: 99%

See 3 more Smart Citations

Exercise builds the scaffold of life: muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

et al. 2022

View full text Add to dashboard Cite

Skeletal muscle extracellular matrix (ECM) is critical for muscle force production and the regulation of important physiological processes during growth, regeneration, and remodelling. ECM remodelling is a tightly orchestrated process, sensitive to multi-directional tensile and compressive stresses and damaging stimuli, and its assessment can convey important information on rehabilitation effectiveness, injury, and disease. Despite its profound importance, ECM biomarkers are underused in studies examining the effects of exercise, disuse, or aging on muscle function, growth, and structure. This review examines patterns of short-and long-term changes in the synthesis and concentrations of ECM markers in biofluids and tissues, which may be useful for describing the time course of ECM remodelling following physical activity and disuse. Forces imposed on the ECM during physical activity critically affect cell signalling while disuse causes non-optimal adaptations, including connective tissue proliferation. The goal of this review is to inform researchers, and rehabilitation, medical, and exercise practitioners better about the role of ECM biomarkers in research and clinical environments to accelerate the development of targeted physical activity treatments, improve ECM status assessment, and enhance function in aging, injury, and disease.

show abstract

Section: Collagensmentioning

confidence: 99%

Section: Growth Factors Enzymes and Modulation Of Ecm Componentsmentioning

confidence: 99%

Section: Growth Factors Enzymes and Modulation Of Ecm Componentsmentioning

confidence: 99%

Section: Growth Factors Enzymes and Modulation Of Ecm Componentsmentioning

confidence: 99%

See 2 more Smart Citations

Exercise builds the scaffold of life: muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Detailed review of sEMG intricacies is beyond the scope of this article, and interested readers are referred to the excellent review by Vigotsky et al [841]. Furthermore, it is also possible to to use the intramuscular or surface electrodes to drive muscle activity, known as electromyostimulation (EMS) [229], neuromuscular electrical stimulation (NMES) [237], functional electrical stimulation [399], electrical muscle stimulation [220], or electrical dry needling [199].…”

Section: Muscle Activation Measurementmentioning

confidence: 99%

Precision strength training: Data-driven artificial intelligence approach to strength and conditioning

Teikari¹,

Pietrusz²

2021

Preprint

View full text Add to dashboard Cite

In strength training, personalised strength training (autoregulation) approaches have been used to individualise exercise programs with monitoring an for dynamic adjustment based on their responses to training. While this transition from tradition-based training to evidence-based training framework has been an improvement in training practices, we argue that the future of strength training will also incorporate deep learning models powered by data. We refer to this data-driven framework as precision strength training inspired by the similar modeling frameworks used in precision medicine. In contrast to current personalised training in which the acquired athlete data is often subject to human expert decision-making, we are anticipating the rise of human-in-the-loop systems with an augmented coach who will be doing decisions collaboratively with the machine. Similar to other precision frameworks, such as precision health, we envision such a future to take decades to be realised and we focus here on practical short-term targets on a way to long-term realisation. In this chapter, we will review the measurement technology needed for continuous data acquisition from an individual during training/physical activity, how to acquire these datasets for the development of such systems and, how a proof-of-concept system could be developed for powerlifting training with applicability to general strength and conditioning (S&C) and physical rehabilitation purposes. Additionally, we will evaluate how the user experience (UX) of the system feedback and visualisation could be designed.

show abstract

The effect of neuromuscular electrical stimulation applied at different muscle lengths on muscle architecture and sarcomere morphology in rats

Uçar

Öner

Kuş

et al. 2023

The Anatomical Record

View full text Add to dashboard Cite

Neuromuscular electrical stimulation (NMES) is often used to increase muscle strength and functionality. Muscle architecture is important for the skeletal muscle functionality. The aim of this study was to investigate the effects of NMES applied at different muscle lengths on skeletal muscle architecture. Twenty‐four rats were randomly assigned to four groups (two NMES groups and two control groups). NMES was applied on the extensor digitorum longus muscle at long muscle length, which is the longest and stretched position of the muscle at 170° plantar flexion, and at medium muscle length, which is the length of the muscle at 90° plantar flexion. A control group was created for each NMES group. NMES was applied for 8 weeks, 10 min/day, 3 days/week. After 8 weeks, muscle samples were removed at the NMES intervention lengths and examined macroscopically, and microscopically using a transmission electron microscope and streo‐microscope. Muscle damage, and architectural properties of the muscle including pennation angle, fibre length, muscle length, muscle mass, physiological cross‐sectional area, fibre length/muscle length, sarcomere length, sarcomere number were then evaluated. There was an increase in fibre length and sarcomere number, and a decrease in pennation angle at both lengths. In the long muscle length group, muscle length was increased, but widespread muscle damage was observed. These results suggest that the intervention of NMES at long muscle length can increase the muscle length but also causes muscle damage. In addition, the greater longitudinal increase in muscle length may be a result of the continuous degeneration‐regeneration cycle.

show abstract

Skeletal Muscle Damage Produced by Electrically Evoked Muscle Contractions

Cited by 13 publications

References 55 publications

Exercise builds the scaffold of life: muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

Exercise builds the scaffold of life: muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

Precision strength training: Data-driven artificial intelligence approach to strength and conditioning

The effect of neuromuscular electrical stimulation applied at different muscle lengths on muscle architecture and sarcomere morphology in rats

Contact Info

Product

Resources

About