Skeletal muscle evaluation by MRI in a rabbit model of acute ischaemia

Zhang, H; Wang, X; Guan, Min; Li, C; Luo, Liangping

doi:10.1259/bjr.20120042

Cited by 12 publications

(14 citation statements)

References 24 publications

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“…These different phases could not be identified based on T 2 alone, indicating that DTI provides supplementary valuable information on muscle injury and regeneration. Similar results were shown in a study by Zhang et al 114 in ischemic muscles of rabbits, which showed an increase of MD and T 2 next to a decrease of FA values after ischemia. During histology the muscle fibers were shown to be swollen, which was accompanied by an increase of extracellular fluid.…”

Section: Ischemia and Denervationsupporting

confidence: 91%

“…90 Similar results were found in the study of femoral artery ligation. However, after 10 days in that setting diffusion values were lower than the initial " (89) " (89,90,114) 5 (89) " (89,90,114) 5 (89) Stimulated # (90) " (90) " (90) Denervation of muscles # (115,116) " (116,117,118) " (115,116) # (116,117,118) " (116) " (116) Acute: Cell swelling and increased extracellular fluid due to inflammatory response Chronic: Reduced fiber diameters due to atrophy Trauma Acute: Cell swelling and increased extracellular fluid due to inflammatory response Chemical induced # (2,88,91) " (88) " (2,88,91) # (88) " (2,88,91) " (88) Chronic: Reduced fiber diameters due to atrophy Overuse 5 (120) " (123,124) 5 (120) 5 (120) Overuse in dystrophic muscles " (120) " (120) " (120) Inflammation in polymyosit...…”

Section: Ischemia and Denervationmentioning

confidence: 80%

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Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Oudeman

Nederveen

Strijkers

et al. 2015

J. Magn. Reson. Imaging

158

153

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Diffusion tensor imaging (DTI) is increasingly applied to study skeletal muscle physiology, anatomy, and pathology. The reason for this growing interest is that DTI offers unique, noninvasive, and potentially diagnostically relevant imaging readouts of skeletal muscle structure that are difficult or impossible to obtain otherwise. DTI has been shown to be feasible within most skeletal muscles. DTI parameters are highly sensitive to patient-specific properties such as age, body mass index (BMI), and gender, but also to more transient factors such as exercise, rest, pressure, temperature, and relative joint position. However, when designing a DTI study one should not only be aware of sensitivity to the above-mentioned factors but also the fact that the DTI parameters are dependent on several acquisition parameters such as echo time, b-value, and diffusion mixing time. The purpose of this review is to provide an overview of DTI studies covering the technical, demographic, and clinical aspects of DTI in skeletal muscles. First we will focus on the critical aspects of the acquisition protocol. Second, we will cover the reported normal variance in skeletal muscle diffusion parameters, and finally we provide an overview of clinical studies and reported parameter changes due to several (patho-)physiological conditions.

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Section: Ischemia and Denervationsupporting

confidence: 91%

Section: Ischemia and Denervationmentioning

confidence: 80%

Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Oudeman

Nederveen

Strijkers

et al. 2015

J. Magn. Reson. Imaging

158

153

View full text Add to dashboard Cite

show abstract

“…This decay reflects intramuscular water content and its organization. Although it is possible to observe four exponential nature of this decay in the normal muscle using specialized techniques, global T2 changes determined from the mono‐exponential fitting of the MR signal acquired using standard multiecho sequences are usually reported …”

Section: Discussionmentioning

confidence: 99%

“…The parameters obtained from relaxation and diffusion imaging of ischaemic hindlimbs were found to change dynamically during degeneration and regeneration processes after femoral artery ligation [18][19][20][21] and provided a useful insight into the therapeutic effects of human and mouse endothelial progenitor cells in mouse models of hindlimb ischaemia. 22,23 Recently, our group has reported that M2 macrophages are involved in the repair process of ischaemic muscle tissue after transplantation of hADSC in immunocompetent mice.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of diffusion properties and transverse relaxation time of mouse ischaemic muscle after administration of human mesenchymal stromal cells derived from adipose tissue

et al. 2019

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Objectives Application of non‐invasive imaging methods plays an important role in the assessment of cellular therapy effects in peripheral artery disease. The purpose of this work was to evaluate the kinetics of MRI‐derived parameters characterizing ischaemic hindlimb muscle after administration of human mesenchymal stromal cells derived from adipose tissue (hADSC) in mice. Materials and methods MRI experiments were performed on a 9.4T Bruker system. The measurement protocol included transverse relaxation time mapping and diffusion tensor imaging. The monitoring period encompassed 14 days after femoral artery ligation and subsequent cell administration. The effect of hADSC transplantation was compared with the effect of normal human dermal fibroblasts (NHDFs) and phosphate‐buffered saline injection. Results The most significant differences between the hADSC group and the remaining ones were observed around day 3 after ischaemia induction (increased transverse relaxation time in the hADSC group in comparison with the control group) and around day 7 (increased transverse relaxation time and decreased third eigenvalue of the diffusion tensor in the hADSC group in comparison with the control and NHDF groups) at the site of hADSC injection. Histologically, it was associated with increased macrophage infiltration at days 3‐7 and with the presence of small regenerating fibres in the ischaemic tissue at day 7. Conclusions Our results underscore the important role of macrophages in mediating the therapeutic effects of hADSCs and confirm the huge potential of magnetic resonance imaging in monitoring of cellular therapy effects.

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“…Furthermore, Holl et al showed an increasing of ADC values of skeletal muscles after denervation [ 30 ]. In addition, muscle ischemia increased intramuscular ADC [ 31 ]. ADC is also able to reflect fine physiological changes of skeletal muscles.…”

Section: Discussionmentioning

confidence: 99%

Apparent Diffusion Coefficient Is a Novel Imaging Biomarker of Myopathic Changes in Liver Cirrhosis

Surov

Paul

Schob

et al. 2018

JCM

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Diffusion weighted imaging can provide information regarding tissue composition and can quantitatively characterize different pathological changes by means of apparent diffusion coefficient (ADC). The study comprised of 114 patients with liver cirrhosis—22 women and 92 men with a mean age of 56.5 ± 9.0 years. In all patients, the Model for End Stage-Liver Disease (MELD) score was calculated. Furthermore, 12 healthy persons (5 women, 7 men), mean age, 42.1 ± 16.2 years, were investigated as a control group. In all cases, magnetic resonance imaging of the liver/trunk was performed using different 3T scanners and diffusion weighted images were obtained with a multi-shot SE-EPI sequence. In all cases, polygonal regions of interest were manually drawn on the ADC maps along the contours of the iliopsoas and paravertebral muscles. The comparison of ADC values in groups was performed by Mann-Whitney-U tests. The association between ADC and MELD score was calculated by Spearman’s rank correlation coefficient. ADC values of the skeletal musculature were statistically much higher in comparison to those in the control group: 1.85 ± 0.46 × 10−3 mm2 s−1 vs. 1.23 ± 0.12 × 10−3 mm2 s−1, p = 0.001. ADC values showed statistically significant correlation with the MELD score (r = 0.473, p = 0.0001). Furthermore, ADC values differed between the subgroups with different values of the MELD score. ADC values correlated slightly with lactate dehydrogenase (LDH) (r = 0.381, p = 0.0001) and tended to correlate with C-reactive protein (CRP) (r = 0.171, p = 0.07) and alanine aminotransferase (ALAT) (r = −0.167, p = 0.076). ADC can reflect muscle changes in liver cirrhosis and shows statistically significant correlation with the MELD score. Therefore, ADC can be used as an imaging biomarker of myopathic changes in liver cirrhosis.

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Skeletal muscle evaluation by MRI in a rabbit model of acute ischaemia

Cited by 12 publications

References 24 publications

Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Monitoring of diffusion properties and transverse relaxation time of mouse ischaemic muscle after administration of human mesenchymal stromal cells derived from adipose tissue

Apparent Diffusion Coefficient Is a Novel Imaging Biomarker of Myopathic Changes in Liver Cirrhosis

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