Skeletal muscle fatty acids shift from oxidation to storage upon dexamethasone treatment in chickens

Wang, X.J.; Song, Zhigang; Jiao, Hongchao

doi:10.1016/j.ygcen.2012.09.013

Cited by 14 publications

(6 citation statements)

References 71 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to eliminate diet effect, rabbits were fed in precise feeding patterns in our present study, and the results showed that heat stress decreased the body weight gain and feed conversion efficiency. The results are consistent with the previous (Wang, Song, Song, Jiao, & Lin, ; Wang, Wei, Wei, Song, Jiao, & Lin, ), and the decreased caloric efficiency and augmented energy expenditure should be responsible for the decreased feed efficiency in stressed animal (Yuan, Lin, Jiang, Jiao, & Song, ).…”

Section: Discussionsupporting

confidence: 92%

Heat stress decreased hair follicle population in rex rabbits

Sun

Zhang

Bai

et al. 2018

Animal Physiology Nutrition

View full text Add to dashboard Cite

The aim of this study was conducted to investigate the effect of heat stress on the hair follicle population and related signalling pathways in rex rabbits. Forty‐eight rabbits were randomly divided into two groups: one group in a high ambient environment (32 ± 2°C, heat stress) and the other group with normal temperature (20 ± 2°C, control). The results show that heat stress decreased the body weight gain and feed conversion rate, rabbit hair length and hair follicle density (p < 0.05). Besides, heat stress suppressed the gene expression of noggin, insulin‐like growth factor 1 (IGF‐1) and IGF‐1 receptor and protein expression of phosphorylated mechanistic target of rapamycin (mTOR) in rabbit skin (p < 0.05), while stimulated significantly the gene expression of bone morphogenetic protein 2 (BMP2) and BMP4 (p < 0.05). Heat exposure did not alter significantly the gene expression of alkaline phosphatase, versican and hepatocyte growth factor compared with the control (p > 0.05). In conclusion, noggin‐BMP, IGF‐1 and mTOR signalling pathways may be associated with the process of heat stress‐repressing hair follicle development.

show abstract

Section: Discussionsupporting

confidence: 92%

Heat stress decreased hair follicle population in rex rabbits

Sun

Zhang

Bai

et al. 2018

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…In a previous study, chickens treated with DEX for both short and long periods all showed elevated circulating corticosterone, indicating a stress response [31][32][33][34]. Oxidative stress is a major pathological mechanism involved in the maladaptation to chronic stress [35].…”

Section: Dex Induced Oxidative Damage In Plasmamentioning

confidence: 90%

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens

et al. 2017

View full text Add to dashboard Cite

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens, Redox Report, 23:1, 68-82, DOI: 10.1080/13510002.2017 Objective: Glucocorticoids (GCs) can induce oxidative damage in skeletal muscles. The purpose of this study was to demonstrate a high caloric (HC) diet rich in soy oil would change the oxidative stress induced by a GC. Methods: The effect of dexamethasone (DEX) and HC diet on oxidative stress in plasma, skeletal muscles (M. pectoralis major, PM; M. biceps femoris, BF), and mitochondria were determined. The biomarkers of oxidative damage and antioxidative enzyme activity were determined. The fatty acid profile of muscles and the activities of complex I and II in mitochondria were measured. Results:The results showed that DEX increased the concentrations of oxidative damage markers in plasma, muscles, and mitochondria. The activity of complex I was significantly suppressed by DEX. DEX-chickens had higher proportions of polyunsaturated fatty acids and lower proportions of monounsaturated fatty acids in the PM. A HC diet decreased the levels of oxidative damage biomarkers in plasma, muscles, and mitochondria. The interaction between DEX and diet suppressed the activities of complex I and II in HC-chickens. Discussion: Oxidative damage in skeletal muscles and mitochondria was the result of GC-induced suppression of the activity of mitochondrial complex I. A HC diet improved the antioxidative capacity and reduced the oxidative damage induced by the GC.

show abstract

“…Cell culture: Primary cultures of chicken embryo myoblasts were prepared using a modified method described previously by Yablonka-Reuveni and Nameroff [ 34 ] and Wang [ 35 ]. In brief, myoblast cells were derived from the breast muscle tissues of 15-day-old embryos.…”

Section: Methodsmentioning

confidence: 99%

Adiponectin Reduces Lipid Content in Chicken Myoblasts by Activating AMPK Signaling Pathway

Wang

et al. 2022

Bioscience Reports

View full text Add to dashboard Cite

Studies in mammals have shown that adiponectin is secreted mainly by adipocytes, and it plays a crucial role in glucose and lipid metabolism in muscles. Clarifying the crosstalk role of adiponectin between adipose tissue and skeletal muscle tissue is very important for internal homeostasis. The glucose and lipid metabolism of chicken is different from that of mammals, and the role of adiponectin in chickens is unclear. Therefore, it is of great significance to study the effect and mechanism of adiponectin on lipid metabolism in chickens. In this study, the regulating effect of adiponectin on lipid metabolism in chicken myoblasts was explored by adding a certain concentration of exogenous recombinant adiponectin. Results showed that adiponectin reduced intracellular lipid content, increasing the mRNA expression of adiponectin receptor and cellular uptake of glucose and fatty acids. In addition, adiponectin activated the 5′ adenosine monophosphate activated protein kinase (AMPK) signaling pathway. The above results suggested that adiponectin reduced intracellular lipid content, mainly by binding to adiponectin receptor, activating AMPK pathway, increasing cellular uptake of glucose and fatty acids, and promoting lipid oxidation.

show abstract

Skeletal muscle fatty acids shift from oxidation to storage upon dexamethasone treatment in chickens

Cited by 14 publications

References 71 publications

Heat stress decreased hair follicle population in rex rabbits

Heat stress decreased hair follicle population in rex rabbits

A high-caloric diet rich in soy oil alleviates oxidative damage of skeletal muscles induced by dexamethasone in chickens

Adiponectin Reduces Lipid Content in Chicken Myoblasts by Activating AMPK Signaling Pathway

Contact Info

Product

Resources

About