Skeletal muscle IGF-1 is lower at rest and after resistance exercise in humans with obesity

Sullivan, B. Patrick; Weiss, Jessica A.; Nie, Yaohui; Garner, Ron T.; Drohan, Cathal J.; Kuang, Shihuan; Stout, Julianne

doi:10.1007/s00421-020-04509-z

Cited by 14 publications

(15 citation statements)

References 40 publications

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“…IGF-1 is a growth factor that regulates both anabolic and catabolic pathways in skeletal muscles, including pathways that regulates muscle mass maintenance, muscle hypertrophy, and muscle protein regulation [569]. However, it was reported that subjects with obesity have lower skeletal muscle IGF-1 mRNA and protein, at rest and following resistance exercise training [570]. After cycling activity during 45 min, it was reported that citrate synthase activity and maximal ATP production rate increase in non-obese, but not in obese, subject muscle samples [571].…”

Section: Skeletal Musclementioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

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Section: Skeletal Musclementioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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“…Yasui et al (2007) showed that musclin mRNA expression in the muscle was reduced by the overexpression of forkhead box O1 (Foxo1) gene expression in the gastrocnemius muscle of skeletal muscle‐specific Foxo1 transgenic mice. Acute resistance exercise in obese patients with insulin resistance elevates Foxo1 mRNA expression levels in the skeletal muscle (Sullivan et al, 2020). In addition, acute concentric muscle contraction exercise transiently induces an increase in the mRNA expression level of Foxo1 in skeletal muscle, which then returns to basal levels (Nedergaard et al, 2007; Stefanetti et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Decreased muscle‐derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes

et al. 2021

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Chronic resistance exercise induces improved hyperglycemia in patients with type 2 diabetes mellitus. Musclin, a muscle‐derived secretory factor, is involved in the induction of insulin resistance via the downregulation of the glucose transporter‐4 (GLUT‐4) signaling pathway in skeletal muscles. However, whether musclin affects the mechanism of resistance exercise remains unclear. This study aimed to clarify whether decreased muscle‐derived musclin secretion in chronic resistance exercise is involved in the improvement of insulin resistance via the GLUT‐4 signaling pathway in rats with type 2 diabetes. Male, 20‐week‐old, Otsuka Long‐Evans Tokushima Fatty (OLETF) rats, a type 2 diabetes model, were randomly divided into two groups: sedentary control (OLETF‐Con) and chronic resistance exercise (OLETF‐RT; climbing a ladder three times a week on alternate days for 8 weeks), whereas Long‐Evans Tokushima Otsuka rats were used as the nondiabetic sedentary control group. OLETF‐Con rats showed increased fasting glucose levels, decreased insulin sensitivity index (QUICKI), muscle GLUT‐4 translocation, and protein kinase B (Akt) phosphorylation, and concomitantly increased muscle musclin expression. In contrast, OLETF‐RT rats significantly reduced muscle musclin expression, improved hyperglycemia, and QUICKI through an accelerated muscle GLUT‐4/Akt signaling pathway. Moreover, chronic resistance exercise‐induced reduction of muscle musclin was correlated with changes in fasting glucose, QUICKI, GLUT‐4 translocation, and Akt phosphorylation. These findings suggest that the reduction in muscle‐derived musclin production by chronic resistance exercise may be involved in improved insulin resistance in rats with type 2 diabetes.

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“…Supporting this notion, a rat model characterized by obesity shows impaired mitochondrial protein synthesis in response to resistance exercise ( Nilsson et al, 2010 ). Finally, upregulation of the expression of certain microRNAs in muscle of humans with obesity impairs expression of muscle mitochondrial proteins ( Tran et al, 2016 ), as well as that of muscle insulin-like growth factor-1 (IGF-1) that regulates protein anabolism in muscle ( Sullivan et al, 2020 ). All these lines of evidence argue for the need for investigation of mechanisms that alter protein metabolism in skeletal muscle of humans with obesity at the levels of transcription and translation of functionally related groups proteins or, most importantly, individual proteins in muscle.…”

Section: Potential Mechanisms Impairing Protein Synthesis In Muscle O...mentioning

confidence: 99%

(Dys)regulation of Protein Metabolism in Skeletal Muscle of Humans With Obesity

Freitas

Katsanos

2022

Front. Physiol.

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Studies investigating the proteome of skeletal muscle present clear evidence that protein metabolism is altered in muscle of humans with obesity. Moreover, muscle quality (i.e., strength per unit of muscle mass) appears lower in humans with obesity. However, relevant evidence to date describing the protein turnover, a process that determines content and quality of protein, in muscle of humans with obesity is quite inconsistent. This is due, at least in part, to heterogeneity in protein turnover in skeletal muscle of humans with obesity. Although not always evident at the mixed-muscle protein level, the rate of synthesis is generally lower in myofibrillar and mitochondrial proteins in muscle of humans with obesity. Moreover, alterations in the synthesis of protein in muscle of humans with obesity are manifested more readily under conditions that stimulate protein synthesis in muscle, including the fed state, increased plasma amino acid availability to muscle, and exercise. Current evidence supports various biological mechanisms explaining impairments in protein synthesis in muscle of humans with obesity, but this evidence is rather limited and needs to be reproduced under more defined experimental conditions. Expanding our current knowledge with direct measurements of protein breakdown in muscle, and more importantly of protein turnover on a protein by protein basis, will enhance our understanding of how obesity modifies the proteome (content and quality) in muscle of humans with obesity.

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Skeletal muscle IGF-1 is lower at rest and after resistance exercise in humans with obesity

Cited by 14 publications

References 40 publications

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Decreased muscle‐derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes

(Dys)regulation of Protein Metabolism in Skeletal Muscle of Humans With Obesity

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