Skeletal muscle in the fight against chronic diseases

Mrowka, Ralf; Westphal, Anika

doi:10.1111/apha.13086

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Muscle strength is a hallmark characteristic of health and human performance (4,32), and maintaining strength over the lifespan helps to reduce chronic disease risk (27). Age, however, is generally a nonmodifiable risk factor for declining muscle strength and declines in strength potentiate at about middle age (16).…”

Section: Introductionmentioning

confidence: 99%

Handgrip Strength Asymmetry and Weakness Are Associated With Future Morbidity Accumulation in Americans

Klawitter

Vincent

Choi

et al. 2021

Journal of Strength and Conditioning Research

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Identifying strength asymmetries in physically deconditioned populations may help in screening and treating persons at risk for morbidities linked to muscle dysfunction. Our investigation sought to examine the associations between handgrip strength (HGS) asymmetry and weakness on accumulating morbidities in aging Americans. The analytic sample included 18,506 Americans aged $50 years from the 2006-2016 Health and Retirement Study. Handgrip strength was measured on each hand with a handgrip dynamometer, and persons with an imbalance in strength .10% between hands had HGS asymmetry. Men with HGS ,26 kg and women with HGS ,16 kg were considered as weak. Subjects reported the presence of healthcare provider-diagnosed morbidities: hypertension, diabetes, cancer, chronic lung disease, cardiovascular disease, stroke, arthritis, and psychiatric problems. Covariate-adjusted ordinal generalized estimating equations analyzed the associations for each HGS asymmetry and weakness group on future accumulating morbidities. Of those included in our study, subjects at baseline were aged 65.0 6 10.2 years, 9,570 (51.7%) had asymmetric HGS, and 996 (5.4%) were weak. Asymmetry alone and weakness alone were associated with 1.09 (95% confidence interval [CI]: 1.04-1.14) and 1.27 (CI: 1.11-1.45) greater odds for future accumulating morbidities, respectively. Having both HGS asymmetry and weakness was associated with 1.46 (CI: 1.29-1.65) greater odds for future accumulating morbidities. Handgrip-strength asymmetry, as another potential indicator of impaired muscle function, is associated with future morbidity status during aging. Exercise professionals and related practitioners should consider examining asymmetry and weakness with handgrip dynamometers as a simple and noninvasive screening method for helping to determine muscle dysfunction and future chronic disease risk.

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Section: Introductionmentioning

confidence: 99%

Handgrip Strength Asymmetry and Weakness Are Associated With Future Morbidity Accumulation in Americans

Klawitter

Vincent

Choi

et al. 2021

Journal of Strength and Conditioning Research

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“…Both of these studies strongly support maintaining a healthy and strong muscle mass throughout one's lifespan especially to prevent sarcopenia and certain diseases. This was further emphasized by Mrowka and Westphal in their article on "skeletal muscle in the fight against chronic disease" published in 2018 [5]. DeCarvalho and associates showed an inverse relationship between skeletal muscle mass adjusted for weight and BMI with metabolic syndrome in both males and females [2].…”

Section: Research General (Heading 2 Intechopen)mentioning

confidence: 94%

“…One area of interest is the impact muscle has on enhancing health and disease prevention [1][2][3][4][5][6][7][8][9][10][11][12]. A healthy and strong muscle mass increases the chance of better managing and preventing certain diseases such as Type II diabetes, cardiovascular disease, certain cancers, dementia and hypertension to name a few [3][4][5]. A healthy muscle mass also helps in maintaining a healthier body weight, the ability to sustain an adequate overall body metabolism with age and an enhanced immune system to help fight off various viruses and disease [6,8,9].…”

Section: Introduction (Heading 1 Intechopen)mentioning

confidence: 99%

Muscle Health: The Gateway to Population Health Management

Gilliam¹,

Terpeluk²

2021

Occupational Wellbeing

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The muscle on your frame is a prime indicator of health and longevity. Dr. Paul Terpeluk with the Cleveland Clinic has stated that muscular strength is the new vital sign of workplace health and safety. Research studies focusing on Type II diabetes, cardiovascular disease, musculo-skeletal injuries, certain cancers and the delay of dementia have shown a strong correlation between disease prevention and muscular strength. IPCS’ database of over 500,000 strength tests have shown a workers’ absolute strength today is at least 14% weaker than the worker 15 years ago and weighs about 8 pounds more. Over the last 10 years, there has been a significant shift by 52% with an increase in the number of workers with a BMI of 35 or greater. The Cleveland Clinic implemented a new hire muscular strength assessment to place new hire applicants into jobs that match their physical capability in 2011. The outcomes show a statistically significant reduction in number of employee health, pharmacy and workers’ compensation claims and costs with overall savings near $25 million. Musculo-skeletal health of the worker can be improved. When a worker maintains good muscular strength, the worker is more productive, has fewer medical claims and workers’ compensation claims.

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“…1 But what role may physical activity play on cognitive function, specifically memory function? 1 But what role may physical activity play on cognitive function, specifically memory function?…”

mentioning

confidence: 99%

“…A recent publication in Acta Physiologica addressed the importance of physical activity in battling cardiovascular disease, discussing several key molecular mediators (e.g, IGF-1, SIRT1, TNF-α). 1 But what role may physical activity play on cognitive function, specifically memory function? Can IGF-1 be a potential mediator?…”

mentioning

confidence: 99%

IGF‐1 in exercise‐induced enhancement of episodic memory

Loprinzi

2018

Acta Physiologica

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Skeletal muscle in the fight against chronic diseases

Cited by 9 publications

References 22 publications

Handgrip Strength Asymmetry and Weakness Are Associated With Future Morbidity Accumulation in Americans

Handgrip Strength Asymmetry and Weakness Are Associated With Future Morbidity Accumulation in Americans

Muscle Health: The Gateway to Population Health Management

IGF‐1 in exercise‐induced enhancement of episodic memory

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