Skeletal Muscle - From Myogenesis to Clinical Relations 2012
DOI: 10.5772/50130
|View full text |Cite
|
Sign up to set email alerts
|

Skeletal Muscle Mitochondrial Function/Dysfunction and Type 2 Diabetes

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

1
1
0

Year Published

2015
2015
2021
2021

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 135 publications
(160 reference statements)
1
1
0
Order By: Relevance
“…Ric2 and Ric4 activated pErk (Figure 2A), while Ric2, Ric3 and Ric4 activated pAkt (Figure 2B). These data corroborate previous suggestions that both Erk and Akt signaling pathways can be activated by insulin [43]. Insulin activation of Akt phosphorylation and signaling pathways have been most frequently associated with Glut4-induced glucose uptake [44].…”
Section: Resultssupporting
confidence: 91%
“…Ric2 and Ric4 activated pErk (Figure 2A), while Ric2, Ric3 and Ric4 activated pAkt (Figure 2B). These data corroborate previous suggestions that both Erk and Akt signaling pathways can be activated by insulin [43]. Insulin activation of Akt phosphorylation and signaling pathways have been most frequently associated with Glut4-induced glucose uptake [44].…”
Section: Resultssupporting
confidence: 91%
“…The activated IRS proteins then serve as downstream modulators to initiate the activation of phosphoinositide-3-kinase (PI3K-PKB) and other downstream molecules. This further promotes the translocation of GLUT4 molecules to the plasma membrane for the uptake of glucose and simultaneously activates the protein phosphatase-1 (PP1) signaling to facilitate glycogen synthesis (Frojdo et al 2009;Siddle 2011;Franquesa et al 2012). Besides insulin action, any molecular inadequacy in insulin secretion may result in the loss of functional capacity of pancreatic β-cells leading to impaired GSIS (Puddu et al 2013).…”
Section: Introductionmentioning
confidence: 97%