Skeletal Muscle Morphology in Patients with Restless Legs Syndrome

Larsson, Britta Wåhlin; Kadi, Fawzi; Ulfberg, Jan; Aulin, Karin Piehl

doi:10.1159/000104712

Cited by 40 publications

(23 citation statements)

References 64 publications

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“…These could represent a sequelae of a general iron regulation problem. 26,27 Some recent studies have suggested an increased difference between morning and evening blood flow 28 and relative hypoxia in leg muscles of RLS/WED patients. 29 It may be that hypoxia or hypoxic pathway activation is one pathway to RLS/WED symptoms.…”

Section: Consequences Of Iron Deficiency: Hypoxic Pathway Activation mentioning

confidence: 99%

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology

Allen

2015

Sleep Medicine Clinics

147

102

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Section: Consequences Of Iron Deficiency: Hypoxic Pathway Activation mentioning

confidence: 99%

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology

Allen

2015

Sleep Medicine Clinics

147

102

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“…Wahlin-Larsson et al (32) studied the morphology of the skeletal muscle in patients with RLS and showed an increased microvessel tortuosity in these individuals. The authors proposed that the disturbance of the balance between vascoconstriction and vasodilation may be responsible for the emergence of the symptoms and that re-establishment of this balance through the movements of the extremity may provide symptomatic relief.…”

Section: Discussionmentioning

confidence: 99%

Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome

Halaç¹,

Kilic²,

Çıkrıkçıoğlu³

et al. 2016

BLL

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OBJECTIVE: The aim of this study was to assess the predisposition for atherosclerosis in patients with RLS through serum sLOX-1 (serum Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) measurements. BACKGROUND: Recent epidemiological studies have suggested an association of RLS with certain chronic conditions such as diabetes mellitus (DM), obesity, hypertension (HT), and hyperlipidemia. LOX-1 is expressed in endothelial cells, macrophages, and in smooth muscle cells under the effect of proatherogenic conditions. METHODS: This study was a prospective, cross-sectional, case-controlled. We measured the serum sLOX-1 levels in 37 restless legs syndrome patients and 38 controls. RESULTS: Serum sLOX-1 level was signifi cantly lower in the patient group. The two groups were similar in glucose, HbA1c, creatinine, LDL cholesterol, TG, HDL, total protein, albumin, AST, ALT, GGT, ALP, HGB, HCT, MCV, transferrin saturation rate (TSR), ferritin, CRP, TSH, FT4, FT3, B12, and folic acid levels. Also the two groups were similar with respect to age at menarche, number of previous births, number of abortions and/or curettage, total duration of breastfeeding, percentage of patients in menopause, and age at menopause. CONCLUSION: Our results may suggest a lower atherosclerotic risk among RLS patients as compared to the general population (Tab. 3, Ref. 33). Text in PDF www.elis.sk.

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“…spinal cord transection, hind-limb suspension, spaceflight and sleep deprivation) neuromuscular activity [20,21,22]. Studies have shown that slow oxidative fibers demonstrate fundamental changes in physiological properties (markedly increased fatigue and altered rates of contraction and relaxation [23]) and are particularly sensitive to decreases in neuromuscular activity, as they are otherwise the most active [24]. Dupont-Versteegden et al [25] have established that adaptations in the expression of the MHC isoforms begin as early as 5 days after spinal cord transection.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Muscle Fibers in Rats with Limb Movements during Sleep after Spinal Cord Injury

et al. 2012

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Background/Aims: Previous studies have demonstrated that spinal cord injury (SCI) results in changes in sleep patterns through increased arousals and limb movements during sleep. Dramatic changes in muscle myosin heavy-chain isoforms have also been reported. The aim of this study was to investigate the characteristics of muscle fibers after SCI in rats with limb movements during sleep. Methods: Forty male Wistar rats were divided into four groups: SHAM, SCI 3, 7 and 15 days. Animals were subjected to electrode insertion surgery, 24-hour baseline sleep recording, SCI, and subsequent sleep recording for 3, 7, or 15 consecutive days. In addition, the gastrocnemius muscle and spinal cord were collected for histopathological/histochemical analyses. Results: Our results indicate a rapid and progressive decrease in the cross-sectional area of type I fibers in the gastrocnemius muscle (35.76–24.74 µm²) after SCI. Additionally, we found SCI-induced changes in sleep patterns. Following SCI, we also observed limb movements in sleeping rats, as well as significant negative moderate correlations between type I fibers and limb movement. Conclusion: Our study strengthened the hypothesis by correlation between changes in types of muscle fiber (decline in type I fibers) and an increase in limb movements during sleep after SCI.

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Skeletal Muscle Morphology in Patients with Restless Legs Syndrome

Cited by 40 publications

References 64 publications

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology

Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in patients with restless legs syndrome

Characteristics of Muscle Fibers in Rats with Limb Movements during Sleep after Spinal Cord Injury

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