Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

Fang, Jun; Sia, Junren; Soto, Jennifer; Wang, Pingping; Li, Lee Ann K.; Hsueh, Yuan Yu; Sun, Raymond Wai‐Yin; Faull, Kym F.; Tidball, James G.; Li, Song

doi:10.1038/s41551-021-00696-y

Cited by 37 publications

(29 citation statements)

References 63 publications

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“…It should be noted that skeletal muscle-resident stem cells (also known as muscle satellite cells) contribute to muscle regeneration in response to various injuries [40][41][42][43][44][45][46][47]. However, a previous study demonstrated that lifelong reduction of satellite cells neither accelerated nor exacerbated sarcopenia and that satellite cells did not contribute to the maintenance of muscle size or fiber type composition during aging, but that their loss may contribute to age-related muscle fibrosis [48].…”

Section: Discussionmentioning

confidence: 99%

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

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Inoue

Piao

et al. 2021

Stem Cells International

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Background. We recently demonstrated that proliferin-1 (PLF-1) functions as an apoptotic cell-derived growth factor and plays an important role in vascular pathobiology. We therefore investigated its role in muscle regeneration in response to cardiotoxin injury. Methods and Results. To determine the effects of PLF-1 on muscle regeneration, we used a CTX-induced skeletal muscle injury model in 9-week-old male mice that were administered with the recombinant PLF-1 (rPLF-1) or neutralizing PLF-1 antibody. The injured muscles exhibited increased levels of PLF-1 gene expression in a time-dependent manner. On day 14 after injury, rPLF-1 supplementation ameliorated CTX-induced alterations in muscle fiber size, interstitial fibrosis, muscle regeneration capacity, and muscle performance. On day 3 postinjury, rPLF-1 increased the levels of proteins or genes for p-Akt, p-mTOR, p-GSK3α/β, p-Erk1/2, p-p38MAPK, interleukin-10, Pax7, MyoD, and Cyclin B1, and it increased the numbers of CD34+/integrin-α7+ muscle stem cells and proliferating cells in the muscles and/or bone marrow of CTX mice. An enzyme-linked immunosorbent assay revealed that rPLF-1 suppressed the levels of plasma tumor necrosis factor-α and interleukin-1β in CTX mice. PLF-1 blocking accelerated CTX-related muscle damage and dysfunction. In C2C12 myoblasts, rPLF-1 increased the levels of proteins for p-Akt, p-mTOR, p-GSK3α/β, p-Erk1/2, and p-p38MAPK as well as cellular functions; and these effects were diminished by the depletion of PLF-1 or silencing of its mannose-6-phosphate receptor. Conclusions. These findings demonstrated that PLF-1 can improve skeletal muscle repair in response to injury, possibly via the modulation of inflammation and proliferation and regeneration, suggesting a novel therapeutic strategy for the management of skeletal muscle diseases.

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Section: Discussionmentioning

confidence: 99%

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Goto

Inoue

Piao

et al. 2021

Stem Cells International

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“…Plants and some animals can regenerate whole bodies such as Hydra (phylum Cnidaria) or flatworm (Platyhelminthes) that regenerate half or entire bodies when severed; plants can regenerate roots from severed stems (where roots did not exist before). When the environment of a leaf tissue segment is manipulated with phytohormones [ 9 , 13 , 14 ], or the environment of cultured mouse neonatal dermal fibroblasts is manipulated by chemicals [ 15 ], regeneration occurs to different degrees. Plants can regenerate whole shoots or roots, and animal cells can regenerate stem cells [ 15 ] or even entire animals [ 16 ].…”

Section: Types Of Regenerationmentioning

confidence: 99%

“…When the environment of a leaf tissue segment is manipulated with phytohormones [ 9 , 13 , 14 ], or the environment of cultured mouse neonatal dermal fibroblasts is manipulated by chemicals [ 15 ], regeneration occurs to different degrees. Plants can regenerate whole shoots or roots, and animal cells can regenerate stem cells [ 15 ] or even entire animals [ 16 ]. Plant cells’ plasticity is revealed in the ability to form shoots or roots from somatic cells and the capacity to generate entier embryos without fertilization, a process is known as somatic embryogenesis, not to confuse with parthenogenesis with is the formation of an embryo in an unfertilized egg cell.…”

Section: Types Of Regenerationmentioning

confidence: 99%

Sex and Regeneration

Reuveni

2021

Biology

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Regeneration is usually regarded as a unique plant or some animal species process. In reality, regeneration is a ubiquitous process in all multicellular organisms. It ranges from response to wounding by healing the wounded tissue to whole body neoforming (remaking of the new body). In a larger context, regeneration is one facet of two reproduction schemes that dominate the evolution of life. Multicellular organisms can propagate their genes asexually or sexually. Here I present the view that the ability to regenerate tissue or whole-body regeneration is also determined by the sexual state of the multicellular organisms (from simple animals such as hydra and planaria to plants and complex animals). The above idea is manifested here by showing evidence that many organisms, organs, or tissues show inhibited or diminished regeneration capacity when in reproductive status compared to organs or tissues in nonreproductive conditions or by exposure to sex hormones.

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“…Plants and some animals can regenerate whole bodies like Hydra (phylum Cnidaria) or flatworm (Platyhelminthes) that regenerate half or entire bodies when severed; plants can regenerate roots from severed stems (where roots did not exist before). When the environment of a leaf tissue segment is manipulated with phytohormones [9,13,14], or the environment of cultured mouse neonatal dermal fibroblasts is manipulated by chemicals [15], regeneration occurs to different degrees. Plants can regenerate whole shoots or roots, and animal cells can regenerate stem cells [15] or even entire animals [16].…”

Section: Types Of Regenerationmentioning

confidence: 99%

Perspective on Sex and Regeneration

Reuveni¹

2021

Preprint

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Regeneration is usually regarded as a unique plant or some animal species process. In reality, regeneration is a ubiquitous process in all multicellular organisms. It ranges from response to wounding by healing the wounded tissue to whole body neoforming (remaking of the new body). In a larger context, regeneration is one facet of two reproduction schemes that dominate the evolution of life. Multicellular organisms can propagate their genes asexually or sexually. Here I present the view that the ability to regenerate tissue or whole-body regeneration is also determined by the sexual state of the multicellular organisms (from simple animals like hydra and planaria to plants and complex animals). The above idea is manifested here by showing evidence that many organisms, organs, or tissues show inhibited or diminished regeneration capacity when in reproductive status compared to the same organism organs or tissues in nonreproductive conditions or by exposure to sex hormones.

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Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro

Cited by 37 publications

References 63 publications

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Sex and Regeneration

Perspective on Sex and Regeneration

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