Skeletal muscle single fiber force production declines early in juvenile male mice with chronic kidney disease

Momb, Brent A.; Patiño, Edwin; Akchurin, Oleh; Miller, Mark S.

doi:10.14814/phy2.15651

Physiological Reports

2023

DOI: 10.14814/phy2.15651

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Skeletal muscle single fiber force production declines early in juvenile male mice with chronic kidney disease

Brent A. Momb

Edwin Patiño

Oleh Akchurin

et al.

Abstract: Chronic kidney disease (CKD) is a term encompassing all individual progressive kidney disorders associated with a gradual loss of kidney function, which culminates at endstage kidney disease (ESKD) or kidney failure (Webster et al., 2017). The United States has one of the highest incidence rates of ESKD in the world (Thurlow et al., 2021).

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Assumptions about the cross-sectional shape of skinned muscle fibers can distort the relationship between muscle force and cross-sectional area

Smith,

Herzog

2023

Journal of Applied Physiology

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Comparisons of muscle force output are often performed after normalization to muscle physiological cross-sectional area (CSA). Differences in force per CSA (i.e., specific force) suggest the presence of physiological differences in contractile function. Permeabilized mammalian skeletal muscle fibres frequently exhibit substantial declines in specific force with increasing CSA, suggesting that smaller fibres are intrinsically stronger than larger fibres of the same group. However, the potential for CSA assessment error to account for CSA-dependent differences in specific force has not received adequate attention. Assessment of fibre CSA typically involves measurement of fibre width and perhaps also height, and CSA is calculated by assuming the cross-sections are either circular or elliptical with major and minor axes aligned with the optical measurement system. Differences between the assumed and real cross-sectional shapes would cause variability in the ratio of assessed CSA (aCSA) to real CSA (rCSA). This variability can insidiously bias aCSA such that large aCSAs typically overstate rCSAs of the fibres they represent, and small aCSAs typically understate the rCSAs of the fibres they represent. As aCSA is the denominator for the specific force calculation, scatterplots of specific force vs aCSA would be expected to show declines in specific force as aCSA increases without a corresponding effect in a scatterplot of specific force vs rCSA. When comparing active and passive muscle forces between data subsets defined by aCSA, the impact of CSA assessment error should be considered before exploring other physiological mechanisms.

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Assumptions about the cross-sectional shape of skinned muscle fibers can distort the relationship between muscle force and cross-sectional area

Smith,

Herzog

2023

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

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Skeletal muscle single fiber force production declines early in juvenile male mice with chronic kidney disease

Cited by 1 publication

References 71 publications

Assumptions about the cross-sectional shape of skinned muscle fibers can distort the relationship between muscle force and cross-sectional area

Assumptions about the cross-sectional shape of skinned muscle fibers can distort the relationship between muscle force and cross-sectional area

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