Skeletal muscle wasting after burn is regulated by a decrease in anabolic signaling in the early flow phase

Dombrecht, Dorien; Van Daele, Ulrike; Van Asbroeck, Birgit; Schieffelers, David R.; Guns, Pieter-Jan; van Breda, Eric

doi:10.1016/j.burns.2023.08.011

Cited by 1 publication

(1 citation statement)

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“…This is highly relevant as alterations in muscle metabolism are thought to be most prevalent in the first few weeks postburn when the hypermetabolic response reaches its peak [ 2 , 44 , 74 ]. Specifically, decreases in anabolic signaling (phosphoinositide 3-kinases-protein kinase B-mammalian target of rapamycin (PI3K–AKT–mTOR) pathway) have been shown to be dominant in the development of muscle wasting during the early postburn period [ 75 ]. As an anabolic stimulant, exercise might then have contributed to the observed retention of muscle size in this study [ 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of early exercise training following severe burn injury: a randomized controlled trial

Schieffelers,

Ru,

Dai

et al. 2024

Burns &Amp; Trauma

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Background Despite being a stable component of burn rehabilitation at later stages of recovery, exercise training is not commonly provided during the acute phase of burns. A lack of evidence surrounding its efficacy and safety in severely burned adults has hampered its implementation in acute burn care. The aim of this study was to investigate the capacity of early exercise training to modulate parameters of postburn muscle wasting and quality of life. Methods Adults <65 years of age with burns ≥40% total burn surface area (TBSA) were randomly allocated to either receive early exercise (n = 29) in addition to standard care or standard care alone (n = 29). Early exercise involved resistance and aerobic training, which commenced as early as possible and lasted for a duration of 6 to 12 weeks, in line with burn center length of stay. Ultrasound-derived quadriceps muscle layer thickness (QMLT) and rectus femoris cross-sectional area (RF-CSA), lower limb muscle force, Eurocol Quality of Life-5 Dimensions and Burn Specific Health Scale Brief (BSHS-B) were assessed 6 and 12 weeks after baseline. Mixed models were fitted to compare between-group changes over time. Results A total of 58 adults [42 (95% confidence interval 40–45) years old; 40–94% TBSA range, 86% previously mechanically ventilated] participated in this study. Exercise commenced 7 days [IQR (interquartile range) 5–9] after burn center admission with an attendance rate of 93%. Allocation to the exercise group had a protective effect on the loss of muscle size from baseline to 6 weeks of follow-up (QMLT: β-coefficient: 0.05 cm, p = 0.010; RF-CSA: β-coefficient: 0.05 cm2, p = 0.045), and resulted in an improved recovery from 6 to 12 weeks (QMLT: β-coefficient: 0.04 cm, p = 0.01; RF-CSA: β-coefficient: 0.06 cm2, p < 0.001). Muscle force increased significantly more in the exercise group than in the control group (β-coefficient: 3.102 N, p < 0.001) between 6 and 12 weeks. Besides a marginally significant effect for the BSHS-B domains ‘affect’ and ‘interpersonal relationships’ between 6 and 12 weeks, no benefits were observed in the other assessed quality-of-life measures. No serious adverse events were reported in the exercise group. Conclusions The results of this study support the use of early exercise training as a feasible and efficacious therapeutic strategy to manage burn-related changes in muscle size and strength in adults with acute severe burn injury.

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