Skeletal Muscles in Chronic Airflow Obstruction

Maltais, François

doi:10.1164/rccm.2307007

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…BROEKHUIZEN et al [23] also found that CRP increases in patients with poor exercise capacity. Indeed, some authors postulate that the skeletal muscle dysfunction is a direct consequence of the systemic effects of the disease [26], whereas others propose that the ''myopathy'' is an independent process that contributes to the systemic inflammatory load of the disease [27]. Whatever the mechanism, the present results indicate that measuring CRP levels in stable conditions could indirectly reflect the exercise capacity of these patients, an important prognostic factor of the disease.…”

Section: Discussionmentioning

confidence: 59%

C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

de-Torres¹,

Córdoba-Lanús²,

et al. 2006

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The aim of this study was to determine the relationship between C-reactive protein (CRP) levels and factors known to predict outcome in stable chronic obstructive pulmonary disease (COPD) patients.The following were studied in 130 stable COPD patients: spirometry, lung volume, arterial oxygen tension (Pa,O 2 ), dyspnoea, 6-min walk distance (6MWD), body mass index, fat-free mass index, BODE (body mass index, obstruction, dyspnoea and exercise capacity), health-related quality of life, smoking status, the presence of cardiovascular risk factors or disease, corticosteroid use and number of exacerbations in the previous year. CRP levels were measured in these patients and in 65 controls. Using univariate and multivariate analyses, any possible association with the predictors of outcomes was evaluated.CRP levels were higher in COPD patients than in controls (4.1 versus 1.8 mg?L C-reactive protein levels in stable chronic obstructive pulmonary disease patients are best correlated with arterial oxygen tension and 6-min walk distance. This should be considered when C-reactive protein levels are measured in stable chronic obstructive pulmonary disease patients.

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Section: Discussionmentioning

confidence: 59%

C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

de-Torres¹,

Córdoba-Lanús²,

et al. 2006

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“…These symptoms curtail their ability to exercise and compromise their cardiac fitness, which further limits their exercise tolerance, creating a vicious downward spiral that can eventually lead to generalized debility and immobility [20]. Indeed, some authors postulate that the skeletal muscle dysfunction is a direct consequence of the systemic effects of the disease [21] whereas others propose that the “myopathy” is an independent process that contributes to the systemic inflammatory load of the disease [22]. Whatever the mechanism, our results indicate that measuring CRP levels in stable conditions could indirectly reflect the exercise capacity of these patients, an important prognostic factor of the disease.…”

Section: Discussionmentioning

confidence: 99%

The relationship between C-reactive protein and prognostic factors in chronic obstructive pulmonary disease

Agarwal

Zaheer

Ahmad

et al. 2013

Multidisciplinary Respiratory Medicine

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BackgroundThe purpose of the study was to determine the relationship between high sensitivity C-reactive protein (hs-CRP) levels and prognostic factors in chronic obstructive pulmonary disease.MethodsWe studied 50 stable COPD patients with: spirometry, 6 minute walk distance, body mass index, GOLD stage (spirometric classification) and smoking status. In these patients hs-CRP values were measured and compared with those of 50 healthy controls. Then the serum hs-CRP was subjected to evaluation for any correlation with the predictors of outcomes in COPD subjects.ResultsHs-CRP levels were higher in COPD patients than in controls (4.82 vs. 0.88 mg/L p < 0.01). Correlation was found between hs-CRP and the following variables: FEV1 (r= −0.813; p < 0.01), 6MWD (r= −0.876; p < 0.01), body mass index (r= −0.710; p < 0.01), GOLD stage (r= 0.797, p < 0.01) and smoking status (r= 0.796; p < 0.01). Using multivariate analysis, FEV1 and 6MWD showed the strongest negative association with hs-CRP levels.ConclusionsThe circulating levels of the inflammatory marker hs-CRP are significantly elevated in patients with COPD, supporting the view that COPD is in part an inflammatory disorder. Hs-CRP levels in stable COPD patients are best correlated with FEV1 and 6-minute walk distance (6MWD). This information should be considered when hs-CRP levels are measured in stable COPD patients.

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“…exercise intolerance) associated with COPD [12][13][14][15] but also to its chronic comorbidities [12,[16][17][18][19]. In particular, cachexia [20], skeletal muscle abnormalities [15,21,22], hypertension [23,24], diabetes [25], coronary artery disease [26][27][28], heart failure [29], pulmonary infections [30][31][32][33][34], cancer [35,36] and pulmonary vascular disease [37] are the most common comorbidities responsible for the clinical manifestations and natural history of COPD [17,18]. In addition to smoking, the other major risk factor for cardiovascular and other chronic comorbid conditions is obesity [38,39].…”

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confidence: 99%

Complex chronic comorbidities of COPD

Fabbri¹,

Luppi²,

Beghè³

et al. 2007

Eur Respir J

565

401

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Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke.The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences.A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation.As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.

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Skeletal Muscles in Chronic Airflow Obstruction

Cited by 11 publications

References 11 publications

C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

The relationship between C-reactive protein and prognostic factors in chronic obstructive pulmonary disease

Complex chronic comorbidities of COPD

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