Skeletal Tetrofosmin Uptake in a Patient Undergoing Myocardial Perfusion Imaging With a Subsequent Diagnosis of Multiple Myeloma

Clinical Significance of Tetrofosm in Extracardiac Uptake During Myocardial Perfusion Imaging

“…Moreover, Tc-99m tetrofosmin incidental uptake in abdominal abnormalities has been detected during cardiac acquisition, when the area being viewed includes the lower thorax and the upper abdomen, in abnormalities of the liver, gallbladder, kidneys, oesophagus, stomach, bowel and bone marrow (Shih et al, 2002). Hepatocellular carcinoma, melanoma, sarcomas and multiple myeloma have also been described in the abdomen, accumulating Tc-99m tetrofosmin in MPS (Fisher et al, 2000;Hadase et al, 2003;Vijayakumar et al, 2005;Yi & Jacobs, 2004). Others, reviewing the raw data cine images of 566 patients during Tl-201 dipyridamole Tc99m tetrofosmin rest-stress MPS, found 234 abnormalities (Shih et al, 2002;Shih et al, 2005) such as: bone marrow visualisation (39.7%), duodenogastric and enterogastric reflux (20.1%), non-visualisation of the gallbladder (13.2%), small-atrophic-scarred, vaguely seen or ectopic kidneys, splenomegaly, liver diseases like hepatomegaly and cirrhosis and breast attenuation causing photopenia in the liver.…”