Skeletonizing En Bloc Esophagectomy for Cancer

Collard, Jean-Marie; Otte, Jean-Bernard; Fiasse, René; Laterre, Pierre‐François; Kock, Marc De; Longueville, Jacques; Glineur, David; Romagnoli, Renato; Reynaert, Marc; Pj, Kestens

doi:10.1097/00000658-200107000-00005

Cited by 99 publications

(70 citation statements)

References 30 publications

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“…Despite recent improvements in surgical techniques, chemotherapy and radiation treatment, the prognosis for patients with advanced disease is still unsatisfactory (Collard et al, 2001;Ando et al, 2003). New approaches to increase the effectiveness of chemotherapy and radiotherapy need to be developed to improve the prognosis of oesophageal cancer.…”

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confidence: 99%

Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma

et al. 2008

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Carbonic anhydrase 9 (CA9) is a protein to be upregulated under exposure to hypoxic conditions. Hypoxic conditions are known to be associated with resistance to chemotherapy and radiotherapy, and with poor cancer prognosis. We examined CA9 expression in surgical specimens from oesophageal squamous cell carcinoma (ESCC) patients (n ¼ 127) using immunohistochemistry and real-time RT -PCR. We also examined CA9 expression and cell proliferation in ESCC cell lines (TE-2, TE-8 and TE-15) and an immortalised human oesophageal cell line (CHEK-1) using real-time RT -PCR, Western blotting, ELISA and MTT assay. Immunohistochemistry, high expression of CA9 was found in 63 of the 127 primary tumour specimens and was correlated with poor outcome (P ¼ 0.0003) and more aggressive/less favourable clinicopathological parameters (tumour size (P ¼ 0.0235), tumour depth (Po0.0001), regional lymph node metastasis (P ¼ 0.0031), distant lymph node metastasis (P ¼ 0.0077), stage (Po0.0001) and blood vessel invasion (P ¼ 0.006)). In vitro, CA9 expression in cultured cells and culture medium was also induced by hypoxia (Po0.01). CA9 is correlated with poor prognosis and malignant phenotype in patients with ESCC, and was upregulated by hypoxia. It is suggested that control of CA9 expression might improve the effectiveness of chemotherapy and radiotherapy in ESCC.

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Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma

et al. 2008

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“…Although diagnostic and surgical techniques have been advanced, survival rates have not been improved in the last decade, and the 5-year survival rate of patients with surgically treated oesophageal cancer remains less than 50% in spite of three-field lymph node dissection and combination chemotherapy and radiotherapy (Torres et al, 1999;Adham et al, 2000;Ando et al, 2000;Collard et al, 2001).…”

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Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

et al. 2003

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The purpose of this study is to investigate the clinical and histopathologic significance of hypoxia-inducible-factor 1a (HIF-1a) expression in oesophageal squamous cell carcinoma. One hundred and thirty surgically resected specimens of OSCC were immunohistochemically assessed for HIF-1a expression with monoclonal antibody. High HIF-1a immunostaining was detected in 40 specimens . The percentage of high HIF-1a expression cases increased with tumour stage according to pTNM system. High HIF-1a expression correlated with pTNM stage , depth of tumour invasion, lymph node metastasis, distant metastasis, lymphatic invasion and positive surgical margin. The overall survival rate was worse in patients with high HIF-1a pattern than in patients with low-expression pattern. Univariate analyses identified high HIF-1a positivity, depth of tumour invasion, lymph node metastasis, distant metastasis, lymphatic invasion, and a positive surgical margin as risk factors. Multivariate analyses indicated that depth of tumour invasion, lymph node metastasis and positive surgical margin, but not HIF-1a, were independent prognostic factors. Survival in patients with a high HIF-1a expression was significantly worse than in those with low expression in patient treated with adjuvant therapy.

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“…Advances in surgical technique and perioperative management have improved survival to some extent. The overall 5-year survival rate, however, generally remains less than 50%, even with the use of multimodality therapy (Ando et al, 1997(Ando et al, , 2000Collard et al, 2001). This is despite a better understanding of the molecular basis of oesophageal carcinogenesis and identification of prognostically important biologic markers.…”

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DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma

et al. 2004

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This is the first report to correlate DARPP-32 immunoreactivity (dopamine and cAMP-regulated phosphoprotein, M r 32 000) to clinicopathological status in human cancer. DARPP-32 is recognised as a neuronal protein. A recent study demonstrated that DARPP-32, and a truncated isoform t-DARPP, are overexpressed in gastric carcinoma during the process of carcinogenesis. The biological function of DARPP-32, however, is still unclear. The purpose of this study was to clarify the roles of DARPP-32 and t-DARPP in oesophageal squamous cell carcinoma (OSCC). Initially, we investigated DARPP-32 and t-DARPP expression in OSCC cell lines by Reverse transcription -polymerase chain reaction and Western blot. DARPP-32 expression was observed in four out of seven (57.1%) cell lines, but t-DARPP expression was not observed in any cell lines. In oesophageal tissue sample, DARPP-32 expression was observed in four out of seven (57.1%) tumour tissues, while t-DARPP was not observed in any tissues. Subsequently, DARPP expression was assessed by immunohistochemistry, using a polyclonal antibody, in tissue sections from 122 patients with primary OSCC. DARPP immunoreactivity was not observed in any normal oesophageal mucous membranes. On the other hand, positive DARPP immunostaining was detected in 37 patients (30.3%) and correlated inversely with pathologic stage (P ¼ 0.0284), pT (P ¼ 0.0438), pN (P ¼ 0.0303) and tumour size (P ¼ 0.012). The overall survival rate was worse in patients with DARPP-negative tumours than in patients with DARPP-positive tumours (P ¼ 0.0453). Interestingly, DARPP expression was observed in only one out of 45 cases of dysplasia. These observations suggest that DARPP-32 (rather than t-DARPP) expression arises after a phase of dysplasia in OSCC, and that tumours expressing DARPP-32 progress less rapidly than DARPP-32-negative tumours.

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Skeletonizing En Bloc Esophagectomy for Cancer

Cited by 99 publications

References 30 publications

Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma

Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma

Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma

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