Skimmianine as a novel therapeutic agent suppresses proliferation and migration of human esophageal squamous cell carcinoma via blocking the activation of ERK1/2

Liu, Yang; Kang, Lin; Li, Bingjie; Zhang, Yang; Zhang, Xiuzhi; Guo, Xiaowan; Fu, Gang; Han, Ho Jae; Zhao, Hongfu

doi:10.4149/neo_2022_211118n1640

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Skimmianine (2) demonstrated cytotoxicity against various cancer cell lines and genotoxicity. It suppressed the proliferation and migration of human esophageal squamous cell carcinoma by blocking the activation of ERK1/2 [46]. Isodictamnine (39), iso-γ-fagarine (40), and γ-fagarine (3), occurring in Glycosmis arborea, showed inhibitory effects toward the tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen [20].…”

Section: Anticancer and Cytotoxic Activitymentioning

confidence: 99%

Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties

Szewczyk,

Pęczek

2023

IJMS

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Furoquinoline alkaloids exhibit a diverse range of effects, making them potential candidates for medicinal applications. Several compounds within this group have demonstrated antimicrobial and antiprotozoal properties. Of great interest is their potential as acetylcholinesterase inhibitors and anti-inflammatory agents in neurodegenerative diseases. The promising biological properties of furoquinoline alkaloids have motivated extensive research in this field. As a result, new compounds have been isolated from this group of secondary metabolites, and numerous pharmacological studies have been conducted to investigate their activity. It is crucial to understand the mechanisms of action of furoquinoline alkaloids due to their potential toxicity. Further research is required to elucidate their mechanisms of action and metabolism. Additionally, the exploration of derivative compounds holds significant potential in enhancing their pharmacological benefits. In vitro plant cultures offer an alternative approach to obtaining alkaloids from plant material, presenting a promising avenue for future investigations.

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Section: Anticancer and Cytotoxic Activitymentioning

confidence: 99%

Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties

Szewczyk,

Pęczek

2023

IJMS

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“…The compound has been used as a starting point to the design of antiparasitic molecules active against Trypanosoma cruzi responsible for the Chagas disease [ 40 ]. Kokusaginine is an isomer of skimmianine and a close analogue of dictamnine, both furoquinolines commonly found in Ruta species and endowed with anticancer properties [ 41 , 42 , 43 ]. There is a sound basis to investigate further the anticancer properties of kokusaginine and related furoquinoline alkaloids.…”

Section: Bioactive Phytochemicals From R Angustifolia ...mentioning

confidence: 99%

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Bailly

2023

Plants

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The genus Ruta in the family Rutaceae includes about 40 species, such as the well-known plants R. graveolens L. (common rue) or R. chalepensis L. (fringed rue), but also much lesser-known species such as R. angustifolia Pers. (narrow-leaved fringed rue). This rue specie, originating from the Mediterranean region, is well-distributed in Southeast Asia, notably in the Indo-Chinese peninsula and other territories. In some countries, such as Malaysia, the plant is used to treat liver diseases and cancer. Extracts of R. angustifolia display antifungal, antiviral and antiparasitic effects. Diverse bioactive natural products have been isolated from the aerial parts of the plant, notably quinoline alkaloids and furocoumarins, which present noticeable anti-inflammatory, antioxidant and/or antiproliferative properties. The present review discusses the main pharmacological properties of the plant and its phytoconstituents, with a focus on the anticancer activities evidenced with diverse alkaloids and terpenoids isolated from the aerial parts of the plant. Quinoline alkaloids such as graveoline, kokusaginine, and arborinine have been characterized and their mode of action defined. Arborinine stands as a remarkable inhibitor of histone demethylase LSD1, endowed with promising anticancer activities. Other anticancer compounds, such as the furocoumarins chalepin and rutamarin, have revealed antitumor effects. Their mechanism of action is discussed together with that of other bioactive natural products, including angustifolin and moskachans. Altogether, R. angustifolia Pers. presents a rich phytochemical profile, fully consistent with the traditional use of the plant to treat cancer. This rue species, somewhat neglected, warrant further investigations as a medicinal plant and a source of inspiration for drug discovery and design.

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Ethnomedicinal uses, phytochemistry, and antiproliferative potential of Vepris soyauxii

Kuete

2024

Advances in Botanical Research

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Skimmianine as a novel therapeutic agent suppresses proliferation and migration of human esophageal squamous cell carcinoma via blocking the activation of ERK1/2

Cited by 5 publications

References 23 publications

Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties

Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Ethnomedicinal uses, phytochemistry, and antiproliferative potential of Vepris soyauxii

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