Skin Aging, Cellular Senescence and Natural Polyphenols

Csekes, Erika; Račková, Lucia

doi:10.3390/ijms222312641

Cited by 146 publications

(104 citation statements)

References 418 publications

(493 reference statements)

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“…An accumulation of senescent cells within tissues is a common hallmark of the aging process [23]. Different cell types in the skin, such as keratinocytes, fibroblasts, melanocytes, and stromal stem cells, can express many of the markers of cellular senescence, e.g., p16INK4a and SA-βgalactosidase [22,[24][25][26]. Interestingly, senescent cells display a pro-inflammatory phenotype since they secrete diverse cytokines, chemokines, and matrix metalloproteinases (MMP).…”

Section: Chronological Aging Of the Skinmentioning

confidence: 99%

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

2022

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Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging. Over 30 years ago, it was observed that UVR induced an immunosuppressive state which inhibited skin contact hypersensitivity. Methods Original and review articles encompassing inflammation and immunosuppression in the photoaging and chronological aging processes were examined from major databases including PubMed, Scopus, and Google Scholar. Results Currently it is known that UVR treatment can trigger a cellular senescence and inflammatory state in the skin. Chronic low-grade inflammation stimulates a counteracting immunosuppression involving an expansion of immunosuppressive cells, e.g., regulatory T cells (Treg), myeloid-derived suppressor cells (MDSC), and regulatory dendritic cells (DCreg). This increased immunosuppressive activity not only suppresses the function of effector immune cells, a state called immunosenescence, but it also induces bystander degeneration of neighboring cells. Interestingly, the chronological aging process also involves an accumulation of pro-inflammatory senescent cells and signs of chronic low-grade inflammation, called inflammaging. There is also clear evidence that inflammaging is associated with an increase in anti-inflammatory and immunosuppressive activities which promote immunosenescence. Conclusion It seems that photoaging and normal aging evoke similar processes driven by the remodeling of the immune system. However, it is likely that there are different molecular mechanisms inducing inflammation and immunosuppression in the accelerated photoaging and the chronological aging processes.

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Section: Chronological Aging Of the Skinmentioning

confidence: 99%

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

2022

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“…As the body's first barrier organ, the skin is susceptible to various stimuli that affect its form and function. Senescent cells have been found to accumulate with age and may contribute to progressive age-related skin aging (Csekes and Račková, 2021). The aging of the global population not only presents an increasing demand for strategies to prevent and treat skin-related diseases but also for skincare products containing natural ingredients capable of alleviating skin aging.…”

Section: Discussionmentioning

confidence: 99%

“…The ROS production during the senescence will cause DNA damage. Both SOD and CAT are important antioxidant enzymes, which can effectively remove free radicals generated in cell metabolism (Csekes and Račková, 2021). MDA is the degradation product of lipid peroxides formed by oxidation reactions in the body, which can cause metabolic dysfunction and even apoptosis of cells (Wang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…With the progression of age, skin aging aggravates the reduction of water content in the skin and the accumulation of many free radicals, resulting in weakened differentiation and reduced vitality of skin cells (Csekes and Račková, 2021). Therefore, in addition to in vitro moisturizing and anti-aging activities, we also investigated in vivo moisturizing and anti-aging activities.…”

Section: Animal Model Evaluation Of Anti-aging and Moisturizing Activ...mentioning

confidence: 99%

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Valorization of Polysaccharides From Benincasa hispida: Physicochemical, Moisturizing, and Antioxidant Skincare Properties

et al. 2022

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Benincasa hispida Cogn. (B. hispida) is a popular vegetable in China, and studies have been reported on B. hispida polysaccharides (BPS) preparation. However, few studies have been reported on its physicochemical and skincare properties. In this study, we analyzed the physicochemical properties of BPS, free radical scavenging capability, moisturizing and antioxidant activities in vitro and in vivo, respectively. Our results show that BPS was an inhomogeneous acidic polysaccharide that could scavenge a variety of free radicals. Also, BPS had a good moisturizing and antioxidant capability both in vitro and in vivo. Specifically, BPS could alter some key antioxidant enzyme activities and pro-inflammatory factor levels via activating the NRF2/HO-1 pathway, thereby preventing H2O2-induced reactive oxygen species (ROS) production and apoptosis of HDF-1 cells. Our results suggest that BPS exhibited favorable moisturizing and anti-aging properties and might be an attractive candidate for the development of anti-aging skincare products.

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“…mTOR signaling is a well-known marker of senescence through SASP regulation [ 39 ] and cell structural changes promotion [ 40 ], among other mechanisms. Thus, over-activation of mTOR promotes the induction of cellular senescence, while its repression blocks cellular senescence, reduces SASP, and prolongs cell life span [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

SCA® Slows the Decline of Functional Parameters Associated with Senescence in Skin Cells

Castro

Paz

González

et al. 2022

IJMS

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The identification of compounds and natural ingredients that can counteract tissue stress and dysfunction induced by aging in skin cells is warranted. Here, we investigated the activity of the secretion from the snail Cryptomphalus aspersa (SCA®), an active compound with well-established beneficial effects on skin integrity and aging. To determinate its senescence-regulation mechanisms, we used a model where damage was induced by hydrogen peroxide (H2O2). The results showed that SCA® positively modulated factors involved in cell senescence such as β-galactosidase and cell morphology, secretory efficiency markers (SIRT1/6 and carboxymethyl-lysine), and metabolic and redox homeostasis (mTOR and ROS). This study demonstrated a novel compound that is activity-modulating, reduces cell senescence, and increases longevity to maintain skin homeostasis and functionality.

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Skin Aging, Cellular Senescence and Natural Polyphenols

Cited by 146 publications

References 418 publications

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Valorization of Polysaccharides From Benincasa hispida: Physicochemical, Moisturizing, and Antioxidant Skincare Properties

SCA® Slows the Decline of Functional Parameters Associated with Senescence in Skin Cells

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