Skin and metabolic syndrome

Adibi, Neda; Robati, Reza M.

doi:10.4103/jrms.jrms_585_20

Cited by 14 publications

(10 citation statements)

References 97 publications

(98 reference statements)

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“…Taking into account the growing prevalence of MetS as a significant health issue worldwide, there has been an increase in the number of studies assessing the relationship between MetS and skin disease in recent years 7 . MetS is a well‐known NCD identified by its side effects, such as end‐organ damage, elevated levels of glucose and blood lipids, as well as high BP 50 . This makes patients susceptible to type 2 diabetes and cardiovascular diseases, such as atherosclerosis and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Sodagar,

Ghane,

Heidari

et al. 2023

Health Science Reports

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Background and AimMetabolic syndrome (MetS) is a well‐known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.MethodsA systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case‐control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA).ResultsA total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta‐analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62−4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).ConclusionsMetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.

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Section: Discussionmentioning

confidence: 99%

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Sodagar,

Ghane,

Heidari

et al. 2023

Health Science Reports

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“…A study directly elucidated that diabetes was significantly associated with FPHL frontal alopecia ( P = 0.023) [ 38 ]. Insulin resistance might induce a hormonal imbalance in circulating androgens, which may explain the relationship between diabetes and AGA [ 39 ]. A prospective study in Taiwan concluded that moderate-to-severe AGA was an independent predictor of diabetes [ 40 ].…”

Section: Endocrine Diseasementioning

confidence: 99%

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

Chen

Xie

Zhang

et al. 2022

Dermatol Ther (Heidelb)

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Androgenetic alopecia is the most common form of hair loss, affecting 85% of men and 40% of women. Androgenetic alopecia is a disease caused by multiple factors, such as genetics, hormones, and systemic diseases; however, the exact cause remains undetermined. Recent studies have found that it is associated with a high incidence of endocrine diseases and other comorbidities. It may not only be a skin disease but also an early signal of underlying systemic diseases. Effective management requires timely diagnosis and treatment initiation. However, in current clinical practice, androgenetic alopecia is still not fully understood or treated. Recognizing the true physical, social, and emotional burden of androgenic alopecia, as well as its associated comorbidities, is the first step in improving the prognosis of affected patients. This review aimed to gather the known pathological factors and provide a reference for clinical physicians to understand androgenetic alopecia and its comorbidities in depth, thereby enabling early recognition of the underlying systemic diseases and providing timely treatment.

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“…[11][12][13] Obesity in the form of visceral adipose increases the blood glucose level and contributes to insulin resistance, which can influence the level of circulating androgens and hence acne development. [9][10][11][12][13] Adipose tissue itself also contains both estrogen and androgen receptors. 9,12,13 Studies have shown that patients with acne who consume food that has a lower glycemic load tend to have less lesions than those who consume diets with a higher glycemic load.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][12][13] Adipose tissue itself also contains both estrogen and androgen receptors. 9,12,13 Studies have shown that patients with acne who consume food that has a lower glycemic load tend to have less lesions than those who consume diets with a higher glycemic load. 10 Weight loss has been shown to improve factors that contribute to both the inflammatory and endogenous factors that contribute to acne.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the incidence of acne vulgaris in patients treated with GLP-1 agonists

Ogunremi,

Ismail,

Dhami

et al. 2024

International Journal of Women’s Dermatology

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Background: With the emerging popularity of GLP-1 receptor agonists, patients are noticing acne vulgaris side effects that are seemingly related to the concurrent treatment with the drug. Due to the correspondence between these drugs’ relatively recent emergence in the U.S. market and their high demand, it is important to investigate what is currently known in the literature so that patients can be properly informed. Objective: The aim of this study is to investigate the relationship, or lack thereof, between glucagon like peptide 1 (GLP-1) receptor agonist usage and acne-related side effects in patients. Methods: A web-based analysis of 6 GLP-1 receptor agonists (3 with a once-weekly dosing schedule, and 3 with a once-daily dosing schedule) was conducted on PubMed online database. Boolean criteria were used to narrow the search. Included in the meta-analysis were 45 research articles that fulfilled the search criteria. Results: The results of the search showed that from the following long-acting GLP-1 receptor agonists, dulaglutide, exenatide extended release, and semaglutide (Wegovy), no conclusive acne side effects were reported. In addition, the results also showed that from the following short-acting GLP-1 receptor agonists, liraglutide, lixisenatide, and semaglutide (Rybelsus), no conclusive acne side effects were reported. Limitations: Limitations of this study include a limited amount of literature regarding the relationship between GLP-1 agonists and acne vulgaris. Conclusion: It is unlikely that GLP-1 agonists themselves are directly responsible for the acne that some patients may develop during treatment. Rather, it is more probable that the weight loss yielded by treatment with these drugs may induce intrinsic physiologic and hormonal changes that induce or exacerbate acne vulgaris in such patients.

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Skin and metabolic syndrome

Cited by 14 publications

References 97 publications

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

A meta-analysis of the incidence of acne vulgaris in patients treated with GLP-1 agonists

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